Mechanistic study of CTHRC1 in promoting Wilms’ tumor progression by regulating M2-type tumor-associated macrophages polarization

Mechanistic study of CTHRC1 in promoting Wilms’ tumor progression by regulating M2-type tumor-associated macrophages polarization

Abstract Background This study aimed to investigate the role of Collagen triple helix repeat protein 1 (CTHRC1) in Wilms’ tumor (WT) progression and elucidate its molecular mechanism in promoting WT malignancy through regulation of M2-type tumor-associated macrophages (M2-TAMs) infiltration and pola...

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Bibliographic Details
Main Authors: Yingquan Zhuo, Xiaoyun Feng, Wenqi Zhang, Jun Du, Xu Sun, Xi Luo, Wei Wang, Hua Jiang, Huajian Gu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Wilms’ tumor
CTHRC1
M2-TAMs
TNFSF9-TNFRSF9
PI3K/Akt signaling pathway
Online Access:https://doi.org/10.1186/s12967-025-06752-4
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