Systemic Sarcoidosis Presenting with Headache and Stroke-Like Episodes
Sarcoidosis is a multisystem granulomatous disorder. Neurological manifestations as a presenting symptom are relatively rare. A 26-year-old male presented with a five-week history of headache suggestive of raised intracranial pressure. He subsequently developed transient episodes of mild right-sided...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Immunology |
| Online Access: | http://dx.doi.org/10.1155/2015/619867 |
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| author | J. Campbell R. Kee D. Bhattacharya P. Flynn M. McCarron A. Fulton |
| author_facet | J. Campbell R. Kee D. Bhattacharya P. Flynn M. McCarron A. Fulton |
| author_sort | J. Campbell |
| collection | DOAJ |
| description | Sarcoidosis is a multisystem granulomatous disorder. Neurological manifestations as a presenting symptom are relatively rare. A 26-year-old male presented with a five-week history of headache suggestive of raised intracranial pressure. He subsequently developed transient episodes of mild right-sided hemiparesis and numbness. Magnetic resonance imaging (MRI) of brain revealed widespread inflammatory white matter lesions, an ischaemic focus in the left corona radiata, and widespread microhaemorrhages consistent with a more diffuse vasculopathy. Serum angiotensin-converting enzyme (ACE) level was normal. Lumbar puncture revealed an elevated opening pressure (36 cmH2O) and inflammatory cerebrospinal fluid (CSF). Computerised tomography (CT) of chest, abdomen, and pelvis revealed widespread lymphadenopathy and biopsy of axillary lymph nodes revealed the presence of noncaseating granulomata in keeping with systemic sarcoidosis. The patient responded well to corticosteroids. This case highlights the importance of considering sarcoidosis to be a rare but potentially treatable cause of stroke in younger patients. |
| format | Article |
| id | doaj-art-df449b7ba94e4a598843a367bdd4a664 |
| institution | Kabale University |
| issn | 2090-6609 2090-6617 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Immunology |
| spelling | doaj-art-df449b7ba94e4a598843a367bdd4a6642025-08-20T03:26:25ZengWileyCase Reports in Immunology2090-66092090-66172015-01-01201510.1155/2015/619867619867Systemic Sarcoidosis Presenting with Headache and Stroke-Like EpisodesJ. Campbell0R. Kee1D. Bhattacharya2P. Flynn3M. McCarron4A. Fulton5Department of Neurology, Royal Victoria Hospital, Belfast BT12 6BA, UKDepartment of Neurology, Royal Victoria Hospital, Belfast BT12 6BA, UKDepartment of Neuroradiology, Royal Victoria Hospital, Belfast BT12 6BA, UKDepartment of Neuroradiology, Royal Victoria Hospital, Belfast BT12 6BA, UKNeurology Centre, Altnagelvin Area Hospital, Londonderry BT47 6SB, UKDepartment of Neurology, Royal Victoria Hospital, Belfast BT12 6BA, UKSarcoidosis is a multisystem granulomatous disorder. Neurological manifestations as a presenting symptom are relatively rare. A 26-year-old male presented with a five-week history of headache suggestive of raised intracranial pressure. He subsequently developed transient episodes of mild right-sided hemiparesis and numbness. Magnetic resonance imaging (MRI) of brain revealed widespread inflammatory white matter lesions, an ischaemic focus in the left corona radiata, and widespread microhaemorrhages consistent with a more diffuse vasculopathy. Serum angiotensin-converting enzyme (ACE) level was normal. Lumbar puncture revealed an elevated opening pressure (36 cmH2O) and inflammatory cerebrospinal fluid (CSF). Computerised tomography (CT) of chest, abdomen, and pelvis revealed widespread lymphadenopathy and biopsy of axillary lymph nodes revealed the presence of noncaseating granulomata in keeping with systemic sarcoidosis. The patient responded well to corticosteroids. This case highlights the importance of considering sarcoidosis to be a rare but potentially treatable cause of stroke in younger patients.http://dx.doi.org/10.1155/2015/619867 |
| spellingShingle | J. Campbell R. Kee D. Bhattacharya P. Flynn M. McCarron A. Fulton Systemic Sarcoidosis Presenting with Headache and Stroke-Like Episodes Case Reports in Immunology |
| title | Systemic Sarcoidosis Presenting with Headache and Stroke-Like Episodes |
| title_full | Systemic Sarcoidosis Presenting with Headache and Stroke-Like Episodes |
| title_fullStr | Systemic Sarcoidosis Presenting with Headache and Stroke-Like Episodes |
| title_full_unstemmed | Systemic Sarcoidosis Presenting with Headache and Stroke-Like Episodes |
| title_short | Systemic Sarcoidosis Presenting with Headache and Stroke-Like Episodes |
| title_sort | systemic sarcoidosis presenting with headache and stroke like episodes |
| url | http://dx.doi.org/10.1155/2015/619867 |
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