Deregulation mechanisms and therapeutic opportunities of p53-responsive microRNAs in diffuse large B-cell lymphoma
Here, we have discussed the molecular mechanisms of p53-responsive microRNAs dysregulation in response to genotoxic stress in diffuse large B-cell lymphoma (DLBCL) patients. The role of micro ribonucleic acids (microRNAs) in p53-signaling cellular stress has been studied. MicroRNAs are the small non...
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2025-01-01
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| author | Elena N. Voropaeva Yuriy L. Orlov Anastasia B. Loginova Olga B. Seregina Vladimir N. Maksimov Tatiana I. Pospelova |
| author_facet | Elena N. Voropaeva Yuriy L. Orlov Anastasia B. Loginova Olga B. Seregina Vladimir N. Maksimov Tatiana I. Pospelova |
| author_sort | Elena N. Voropaeva |
| collection | DOAJ |
| description | Here, we have discussed the molecular mechanisms of p53-responsive microRNAs dysregulation in response to genotoxic stress in diffuse large B-cell lymphoma (DLBCL) patients. The role of micro ribonucleic acids (microRNAs) in p53-signaling cellular stress has been studied. MicroRNAs are the small non-coding RNAs, which regulate genes expression at post-transcriptional level. Many of them play a crucial role in carcinogenesis and may act as oncogenes or suppressor of tumor growth. The understanding of the effect of p53-responsive microRNA dysregulation on oncogenesis achieved in recent decades opens wide opportunities for the diagnosis, prediction and of microRNA-based cancer therapy. Development of new bioinformatics tools and databases for microRNA supports DLBCL research. We overview the studies on the role of miRNAs in regulating gene expression associated with tumorigenesis processes, with particular emphasis on their role as tumor growth-suppressing factors. The starting point is a brief description of the classical microRNA biogenesis pathway and the role of p53 in regulating the expression of these molecules. We analyze various molecular mechanisms leading to this dysregulation, including mutations in the TP53 gene, DNA methylation, changes in host-genes expression or microRNA gene copy number, mutations in microRNA and microRNA biogenesis genes. |
| format | Article |
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| institution | Kabale University |
| issn | 2167-8359 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | PeerJ Inc. |
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| spelling | doaj-art-df418808c2be41f49a08ea1df19a8fb22025-01-09T15:05:10ZengPeerJ Inc.PeerJ2167-83592025-01-0113e1866110.7717/peerj.18661Deregulation mechanisms and therapeutic opportunities of p53-responsive microRNAs in diffuse large B-cell lymphomaElena N. Voropaeva0Yuriy L. Orlov1Anastasia B. Loginova2Olga B. Seregina3Vladimir N. Maksimov4Tatiana I. Pospelova5Research Institute of Internal and Preventive Medicine - Branch of the Federal State Budget Scientific Institution “The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences”, Novosibirsk, RussiaThe Digital Health Center, I.M Sechenov First Moscow State Medical University, Moscow, RussiaNovosibirsk State Medical University of the Ministry of Health of the Russian Federation, Novosibirsk, RussiaNovosibirsk State Medical University of the Ministry of Health of the Russian Federation, Novosibirsk, RussiaResearch Institute of Internal and Preventive Medicine - Branch of the Federal State Budget Scientific Institution “The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences”, Novosibirsk, RussiaNovosibirsk State Medical University of the Ministry of Health of the Russian Federation, Novosibirsk, RussiaHere, we have discussed the molecular mechanisms of p53-responsive microRNAs dysregulation in response to genotoxic stress in diffuse large B-cell lymphoma (DLBCL) patients. The role of micro ribonucleic acids (microRNAs) in p53-signaling cellular stress has been studied. MicroRNAs are the small non-coding RNAs, which regulate genes expression at post-transcriptional level. Many of them play a crucial role in carcinogenesis and may act as oncogenes or suppressor of tumor growth. The understanding of the effect of p53-responsive microRNA dysregulation on oncogenesis achieved in recent decades opens wide opportunities for the diagnosis, prediction and of microRNA-based cancer therapy. Development of new bioinformatics tools and databases for microRNA supports DLBCL research. We overview the studies on the role of miRNAs in regulating gene expression associated with tumorigenesis processes, with particular emphasis on their role as tumor growth-suppressing factors. The starting point is a brief description of the classical microRNA biogenesis pathway and the role of p53 in regulating the expression of these molecules. We analyze various molecular mechanisms leading to this dysregulation, including mutations in the TP53 gene, DNA methylation, changes in host-genes expression or microRNA gene copy number, mutations in microRNA and microRNA biogenesis genes.https://peerj.com/articles/18661.pdfDiffuse Large B-cell Lymphoma (DLBCL)microRNA regulationp53 response elementsGene expressionmicroRNA-based cancer therapy |
| spellingShingle | Elena N. Voropaeva Yuriy L. Orlov Anastasia B. Loginova Olga B. Seregina Vladimir N. Maksimov Tatiana I. Pospelova Deregulation mechanisms and therapeutic opportunities of p53-responsive microRNAs in diffuse large B-cell lymphoma PeerJ Diffuse Large B-cell Lymphoma (DLBCL) microRNA regulation p53 response elements Gene expression microRNA-based cancer therapy |
| title | Deregulation mechanisms and therapeutic opportunities of p53-responsive microRNAs in diffuse large B-cell lymphoma |
| title_full | Deregulation mechanisms and therapeutic opportunities of p53-responsive microRNAs in diffuse large B-cell lymphoma |
| title_fullStr | Deregulation mechanisms and therapeutic opportunities of p53-responsive microRNAs in diffuse large B-cell lymphoma |
| title_full_unstemmed | Deregulation mechanisms and therapeutic opportunities of p53-responsive microRNAs in diffuse large B-cell lymphoma |
| title_short | Deregulation mechanisms and therapeutic opportunities of p53-responsive microRNAs in diffuse large B-cell lymphoma |
| title_sort | deregulation mechanisms and therapeutic opportunities of p53 responsive micrornas in diffuse large b cell lymphoma |
| topic | Diffuse Large B-cell Lymphoma (DLBCL) microRNA regulation p53 response elements Gene expression microRNA-based cancer therapy |
| url | https://peerj.com/articles/18661.pdf |
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