Abnormal dynamic functional networks during pain-free periods: Resting-state co-activation pattern analysis in primary dysmenorrhea
Chronic pain alters the configuration of brain functional networks. Primary dysmenorrhea (PDM) is a form of chronic visceral pain, which has been identified spatial alterations in brain functional networks using static functional connectivity analysis methods. However, the dynamics alterations of br...
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Elsevier
2025-02-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811925000096 |
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| author | Huiping Liu Xing Su Meiling Shang Ling Ma Weixian Bai Hui Wang Lu Quan Youjun Li Zigang Huang Jiaxi He Wanghuan Dun Yuchen Zhang |
| author_facet | Huiping Liu Xing Su Meiling Shang Ling Ma Weixian Bai Hui Wang Lu Quan Youjun Li Zigang Huang Jiaxi He Wanghuan Dun Yuchen Zhang |
| author_sort | Huiping Liu |
| collection | DOAJ |
| description | Chronic pain alters the configuration of brain functional networks. Primary dysmenorrhea (PDM) is a form of chronic visceral pain, which has been identified spatial alterations in brain functional networks using static functional connectivity analysis methods. However, the dynamics alterations of brain functional networks during pain-free periovulation phase remain unclear. Using the co-activation pattern (CAP) method, we investigated the dynamic network characteristics of brain functional networks and their relationship with pain-related emotions in a sample of 59 women with PDM and 57 demographically matched healthy controls (HCs) during the pain-free periovulation phase. We observed that patients with PDM showed significant alterations in brain dynamics compared to HCs in the slow-4 (0.027–0.073 Hz) frequency band during the pain-free periovulation phase. Additionally, the fraction of time for CAP state 2 was positively correlated with the Pain Catastrophizing Scale-helplessness score, while the persistence time for CAP state 1 was positively correlated with the McGill Pain Questionnaire score. Our results provide new insights, suggesting that the atypical brain functional network dynamics may serve as a potential biological marker of patients with PDM during the pain-free periovulation phase. |
| format | Article |
| id | doaj-art-df3f6fc822c24c3590a818940da40c48 |
| institution | Kabale University |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-df3f6fc822c24c3590a818940da40c482025-01-23T05:26:23ZengElsevierNeuroImage1095-95722025-02-01306121009Abnormal dynamic functional networks during pain-free periods: Resting-state co-activation pattern analysis in primary dysmenorrheaHuiping Liu0Xing Su1Meiling Shang2Ling Ma3Weixian Bai4Hui Wang5Lu Quan6Youjun Li7Zigang Huang8Jiaxi He9Wanghuan Dun10Yuchen Zhang11School of Future Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China; Rehabilitation Medicine Department, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, The Key Laboratory of Neuro-informatics and Rehabilitation Engineering of Ministry of Civil Affairs, Xi'an, Shaanxi, China; Research Center for Brain-inspired Intelligence, Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaSchool of Future Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China; Rehabilitation Medicine Department, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaRehabilitation Medicine Department, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaDepartment of Medical Imaging, Xi'an No.3 Hospital, Xi'an, Shaanxi, ChinaSchool of Future Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaRehabilitation Medicine Department, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, The Key Laboratory of Neuro-informatics and Rehabilitation Engineering of Ministry of Civil Affairs, Xi'an, Shaanxi, China; Research Center for Brain-inspired Intelligence, Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, The Key Laboratory of Neuro-informatics and Rehabilitation Engineering of Ministry of Civil Affairs, Xi'an, Shaanxi, China; Research Center for Brain-inspired Intelligence, Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaHealth Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaRehabilitation Medicine Department, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China; Corresponding author at: Department of Nuclear Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China.Department of Nuclear Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China; Corresponding author at: Department of Nuclear Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China.Chronic pain alters the configuration of brain functional networks. Primary dysmenorrhea (PDM) is a form of chronic visceral pain, which has been identified spatial alterations in brain functional networks using static functional connectivity analysis methods. However, the dynamics alterations of brain functional networks during pain-free periovulation phase remain unclear. Using the co-activation pattern (CAP) method, we investigated the dynamic network characteristics of brain functional networks and their relationship with pain-related emotions in a sample of 59 women with PDM and 57 demographically matched healthy controls (HCs) during the pain-free periovulation phase. We observed that patients with PDM showed significant alterations in brain dynamics compared to HCs in the slow-4 (0.027–0.073 Hz) frequency band during the pain-free periovulation phase. Additionally, the fraction of time for CAP state 2 was positively correlated with the Pain Catastrophizing Scale-helplessness score, while the persistence time for CAP state 1 was positively correlated with the McGill Pain Questionnaire score. Our results provide new insights, suggesting that the atypical brain functional network dynamics may serve as a potential biological marker of patients with PDM during the pain-free periovulation phase.http://www.sciencedirect.com/science/article/pii/S1053811925000096Brain networkCo-activation patternDynamicsPain-free periovulation phasePrimary dysmenorrhea |
| spellingShingle | Huiping Liu Xing Su Meiling Shang Ling Ma Weixian Bai Hui Wang Lu Quan Youjun Li Zigang Huang Jiaxi He Wanghuan Dun Yuchen Zhang Abnormal dynamic functional networks during pain-free periods: Resting-state co-activation pattern analysis in primary dysmenorrhea NeuroImage Brain network Co-activation pattern Dynamics Pain-free periovulation phase Primary dysmenorrhea |
| title | Abnormal dynamic functional networks during pain-free periods: Resting-state co-activation pattern analysis in primary dysmenorrhea |
| title_full | Abnormal dynamic functional networks during pain-free periods: Resting-state co-activation pattern analysis in primary dysmenorrhea |
| title_fullStr | Abnormal dynamic functional networks during pain-free periods: Resting-state co-activation pattern analysis in primary dysmenorrhea |
| title_full_unstemmed | Abnormal dynamic functional networks during pain-free periods: Resting-state co-activation pattern analysis in primary dysmenorrhea |
| title_short | Abnormal dynamic functional networks during pain-free periods: Resting-state co-activation pattern analysis in primary dysmenorrhea |
| title_sort | abnormal dynamic functional networks during pain free periods resting state co activation pattern analysis in primary dysmenorrhea |
| topic | Brain network Co-activation pattern Dynamics Pain-free periovulation phase Primary dysmenorrhea |
| url | http://www.sciencedirect.com/science/article/pii/S1053811925000096 |
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