HOTAIR Knockdown Increases the Sensitivity of Hepatocellular Carcinoma Cells to Sorafenib by Disrupting miR-145-5p/HK2 Axis-Mediated Mitochondrial Function and Glycolysis

Background: Frequent drug resistance seriously limits the therapeutic efficacy of sorafenib in advanced hepatocellular carcinoma (HCC). Strategies to increase the response to sorafenib are limited, and the underlying mechanism to facilitate such an increase is not entirely underst...

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Bibliographic Details
Main Authors: Meiyu Cheng, Bingrong Wang, Lina Duan, Yu Jin, Wenda Zhang, Na Li
Format: Article
Language:English
Published: IMR Press 2025-05-01
Series:Frontiers in Bioscience-Landmark
Subjects:
Online Access:https://www.imrpress.com/journal/FBL/30/5/10.31083/FBL37368
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