Beta activity in human anterior cingulate cortex mediates reward biases
Abstract The rewards that we get from our choices and actions can have a major influence on our future behavior. Understanding how reward biasing of behavior is implemented in the brain is important for many reasons, including the fact that diminution in reward biasing is a hallmark of clinical depr...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-49600-7 |
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| author | Jiayang Xiao Joshua A. Adkinson John Myers Anusha B. Allawala Raissa K. Mathura Victoria Pirtle Ricardo Najera Nicole R. Provenza Eleonora Bartoli Andrew J. Watrous Denise Oswalt Ron Gadot Adrish Anand Ben Shofty Sanjay J. Mathew Wayne K. Goodman Nader Pouratian Xaq Pitkow Kelly R. Bijanki Benjamin Hayden Sameer A. Sheth |
| author_facet | Jiayang Xiao Joshua A. Adkinson John Myers Anusha B. Allawala Raissa K. Mathura Victoria Pirtle Ricardo Najera Nicole R. Provenza Eleonora Bartoli Andrew J. Watrous Denise Oswalt Ron Gadot Adrish Anand Ben Shofty Sanjay J. Mathew Wayne K. Goodman Nader Pouratian Xaq Pitkow Kelly R. Bijanki Benjamin Hayden Sameer A. Sheth |
| author_sort | Jiayang Xiao |
| collection | DOAJ |
| description | Abstract The rewards that we get from our choices and actions can have a major influence on our future behavior. Understanding how reward biasing of behavior is implemented in the brain is important for many reasons, including the fact that diminution in reward biasing is a hallmark of clinical depression. We hypothesized that reward biasing is mediated by the anterior cingulate cortex (ACC), a cortical hub region associated with the integration of reward and executive control and with the etiology of depression. To test this hypothesis, we recorded neural activity during a biased judgment task in patients undergoing intracranial monitoring for either epilepsy or major depressive disorder. We found that beta (12–30 Hz) oscillations in the ACC predicted both associated reward and the size of the choice bias, and also tracked reward receipt, thereby predicting bias on future trials. We found reduced magnitude of bias in depressed patients, in whom the beta-specific effects were correspondingly reduced. Our findings suggest that ACC beta oscillations may orchestrate the learning of reward information to guide adaptive choice, and, more broadly, suggest a potential biomarker for anhedonia and point to future development of interventions to enhance reward impact for therapeutic benefit. |
| format | Article |
| id | doaj-art-df2f2ba5e3734abf8484648fb22b2d48 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-df2f2ba5e3734abf8484648fb22b2d482025-08-20T03:27:11ZengNature PortfolioNature Communications2041-17232024-07-0115111310.1038/s41467-024-49600-7Beta activity in human anterior cingulate cortex mediates reward biasesJiayang Xiao0Joshua A. Adkinson1John Myers2Anusha B. Allawala3Raissa K. Mathura4Victoria Pirtle5Ricardo Najera6Nicole R. Provenza7Eleonora Bartoli8Andrew J. Watrous9Denise Oswalt10Ron Gadot11Adrish Anand12Ben Shofty13Sanjay J. Mathew14Wayne K. Goodman15Nader Pouratian16Xaq Pitkow17Kelly R. Bijanki18Benjamin Hayden19Sameer A. Sheth20Department of Neurosurgery, Baylor College of MedicineDepartment of Neurosurgery, Baylor College of MedicineDepartment of Neurosurgery, Baylor College of MedicineSchool of Engineering, Brown UniversityDepartment of Neurosurgery, Baylor College of MedicineDepartment of Neurosurgery, Baylor College of MedicineDepartment of Neurosurgery, Baylor College of MedicineDepartment of Neurosurgery, Baylor College of MedicineDepartment of Neurosurgery, Baylor College of MedicineDepartment of Neurosurgery, Baylor College of MedicineDepartment of Neurosurgery, Baylor College of MedicineDepartment of Neurosurgery, Baylor College of MedicineDepartment of Neurosurgery, Baylor College of MedicineDepartment of Neurosurgery, University of UtahDepartment of Psychiatry and Behavioral Sciences, Baylor College of MedicineDepartment of Psychiatry and Behavioral Sciences, Baylor College of MedicineDepartment of Neurological Surgery, UT Southwestern Medical CenterDepartment of Neuroscience, Baylor College of MedicineDepartment of Neurosurgery, Baylor College of MedicineDepartment of Neurosurgery, Baylor College of MedicineDepartment of Neurosurgery, Baylor College of MedicineAbstract The rewards that we get from our choices and actions can have a major influence on our future behavior. Understanding how reward biasing of behavior is implemented in the brain is important for many reasons, including the fact that diminution in reward biasing is a hallmark of clinical depression. We hypothesized that reward biasing is mediated by the anterior cingulate cortex (ACC), a cortical hub region associated with the integration of reward and executive control and with the etiology of depression. To test this hypothesis, we recorded neural activity during a biased judgment task in patients undergoing intracranial monitoring for either epilepsy or major depressive disorder. We found that beta (12–30 Hz) oscillations in the ACC predicted both associated reward and the size of the choice bias, and also tracked reward receipt, thereby predicting bias on future trials. We found reduced magnitude of bias in depressed patients, in whom the beta-specific effects were correspondingly reduced. Our findings suggest that ACC beta oscillations may orchestrate the learning of reward information to guide adaptive choice, and, more broadly, suggest a potential biomarker for anhedonia and point to future development of interventions to enhance reward impact for therapeutic benefit.https://doi.org/10.1038/s41467-024-49600-7 |
| spellingShingle | Jiayang Xiao Joshua A. Adkinson John Myers Anusha B. Allawala Raissa K. Mathura Victoria Pirtle Ricardo Najera Nicole R. Provenza Eleonora Bartoli Andrew J. Watrous Denise Oswalt Ron Gadot Adrish Anand Ben Shofty Sanjay J. Mathew Wayne K. Goodman Nader Pouratian Xaq Pitkow Kelly R. Bijanki Benjamin Hayden Sameer A. Sheth Beta activity in human anterior cingulate cortex mediates reward biases Nature Communications |
| title | Beta activity in human anterior cingulate cortex mediates reward biases |
| title_full | Beta activity in human anterior cingulate cortex mediates reward biases |
| title_fullStr | Beta activity in human anterior cingulate cortex mediates reward biases |
| title_full_unstemmed | Beta activity in human anterior cingulate cortex mediates reward biases |
| title_short | Beta activity in human anterior cingulate cortex mediates reward biases |
| title_sort | beta activity in human anterior cingulate cortex mediates reward biases |
| url | https://doi.org/10.1038/s41467-024-49600-7 |
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