Recent advances in osteonecrosis of the femoral head: a focus on mesenchymal stem cells and adipocytes

Recent advances in osteonecrosis of the femoral head: a focus on mesenchymal stem cells and adipocytes

Abstract Osteonecrosis of the femoral head (ONFH) is a debilitating orthopedic disease characterized by femoral head collapse and destruction of bone and articular cartilage, resulting in severe joint pain and loss of hip mobility. Bone marrow mesenchymal stem cells (BMSCs) exhibit multilineage diff...

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Bibliographic Details
Main Authors: Shilei Zhang, Haojue Wang, Qi Meng, Wayne Yuk-wai Lee, Ziqing Li, Shui Sun
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Osteonecrosis of the femoral head
Mesenchymal stem cell
Adipocyte
Signaling pathways
Adipokine
Online Access:https://doi.org/10.1186/s12967-025-06564-6
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