A Transdermal Measurement Platform Based on Microfluidics
The Franz diffusion cell is one of the most widely used devices to evaluate transdermal drug delivery. However, this static and nonflowing system has some limitations, such as a relatively large solution volume and skin area and the development of gas bubbles during sampling. To overcome these disad...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2017/9343824 |
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| _version_ | 1850167929260212224 |
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| author | Wen-Ying Huang Jung-Ping Huang Chia-Ching Lin Yung-Sheng Lin |
| author_facet | Wen-Ying Huang Jung-Ping Huang Chia-Ching Lin Yung-Sheng Lin |
| author_sort | Wen-Ying Huang |
| collection | DOAJ |
| description | The Franz diffusion cell is one of the most widely used devices to evaluate transdermal drug delivery. However, this static and nonflowing system has some limitations, such as a relatively large solution volume and skin area and the development of gas bubbles during sampling. To overcome these disadvantages, this study provides a proof of concept for miniaturizing models of transdermal delivery by using a microfluidic chip combined with a diffusion cell. The proposed diffusion microchip system requires only 80 μL of sample solution and provides flow circulation. Two model compounds, Coomassie Brilliant Blue G-250 and potassium ferricyanide, were successfully tested for transdermal delivery experiments. The diffusion rate is high for a high sample concentration or a large membrane pore size. The developed diffusion microchip system, which is feasible, can be applied for transdermal measurement in the future. |
| format | Article |
| id | doaj-art-df295d2dddc443e3a8295f24ca3ec6e0 |
| institution | OA Journals |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-df295d2dddc443e3a8295f24ca3ec6e02025-08-20T02:21:06ZengWileyJournal of Chemistry2090-90632090-90712017-01-01201710.1155/2017/93438249343824A Transdermal Measurement Platform Based on MicrofluidicsWen-Ying Huang0Jung-Ping Huang1Chia-Ching Lin2Yung-Sheng Lin3Department of Applied Cosmetology and Master Program of Cosmetic Science, Hungkuang University, Taichung 43302, TaiwanDepartment of Applied Cosmetology and Master Program of Cosmetic Science, Hungkuang University, Taichung 43302, TaiwanDepartment of Applied Cosmetology and Master Program of Cosmetic Science, Hungkuang University, Taichung 43302, TaiwanDepartment of Chemical Engineering, National United University, Miaoli 36063, TaiwanThe Franz diffusion cell is one of the most widely used devices to evaluate transdermal drug delivery. However, this static and nonflowing system has some limitations, such as a relatively large solution volume and skin area and the development of gas bubbles during sampling. To overcome these disadvantages, this study provides a proof of concept for miniaturizing models of transdermal delivery by using a microfluidic chip combined with a diffusion cell. The proposed diffusion microchip system requires only 80 μL of sample solution and provides flow circulation. Two model compounds, Coomassie Brilliant Blue G-250 and potassium ferricyanide, were successfully tested for transdermal delivery experiments. The diffusion rate is high for a high sample concentration or a large membrane pore size. The developed diffusion microchip system, which is feasible, can be applied for transdermal measurement in the future.http://dx.doi.org/10.1155/2017/9343824 |
| spellingShingle | Wen-Ying Huang Jung-Ping Huang Chia-Ching Lin Yung-Sheng Lin A Transdermal Measurement Platform Based on Microfluidics Journal of Chemistry |
| title | A Transdermal Measurement Platform Based on Microfluidics |
| title_full | A Transdermal Measurement Platform Based on Microfluidics |
| title_fullStr | A Transdermal Measurement Platform Based on Microfluidics |
| title_full_unstemmed | A Transdermal Measurement Platform Based on Microfluidics |
| title_short | A Transdermal Measurement Platform Based on Microfluidics |
| title_sort | transdermal measurement platform based on microfluidics |
| url | http://dx.doi.org/10.1155/2017/9343824 |
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