Ablative Volume of Radiofrequency Ablation Related to Intrahepatic Recurrence-Free Survival of Hepatocellular Carcinoma
Purpose The aim of this study was to evaluate intrahepatic recurrence-free survival of hepatocellular carcinoma (HCC) after Radiofrequency ablation (RFA) Methods A retrospective cohort study of single HCC treated by RFA between 2015 and 2017. Fifty patients were enrolled in the study. Tum...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2021-07-01
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| Series: | The Arab Journal of Interventional Radiology |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1742654 |
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| author | Nakarin Inmutto Siripong Thaimai Tanop Srisuwan Thanate Kattipathanapong Natthaphong Nimitrungtawee |
| author_facet | Nakarin Inmutto Siripong Thaimai Tanop Srisuwan Thanate Kattipathanapong Natthaphong Nimitrungtawee |
| author_sort | Nakarin Inmutto |
| collection | DOAJ |
| description | Purpose The aim of this study was to evaluate intrahepatic recurrence-free survival of hepatocellular carcinoma (HCC) after Radiofrequency ablation (RFA)
Methods A retrospective cohort study of single HCC treated by RFA between 2015 and 2017. Fifty patients were enrolled in the study. Tumor volume and ablative volume were measured by using Syngo.via application (Siemen Healthineers, United States). Ablative volume classified into small and large ablative volumes. Ablative margin was evaluated by visual comparison between pre- and post-RFA images and classified into two groups: closed ablative margin (<0.5cm) and large ablative margin (>0.5 cm). The recurrence tumor was classified as local tumor progression (LTP) and intrahepatic distant recurrence (IDR). The recurrence-free survival rate and independent risk for tumor recurrence were analyzed.
Results Recurrence-free survival rate at the first, second, third, and fourth year after RFA was 83, 56, 44, and 44%, respectively. The average recurrence-free survival time in large ablative volume group was significantly longer than small ablative volume group (31.57 vs. 8.50 months, p = 0.003). A significant independent risk factor for tumor recurrence was large ablative volume (hazard ratio = 0.12, 95% confidence interval = 0.02–0.84, p = 0.033). The IDR group had ratio of actual ablative volume by ideal ablative volume (ablative ratio) higher than LTP group and nonrecurrent group.
Conclusion The large ablative volume prevented tumor recurrence and increased recurrence-free survival rate. But aggressive ablation with high ablative volume ratio could increase risk of IDR. |
| format | Article |
| id | doaj-art-df259666d7764f0fb4e62f64e714961c |
| institution | DOAJ |
| issn | 2542-7075 2542-7083 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Arab Journal of Interventional Radiology |
| spelling | doaj-art-df259666d7764f0fb4e62f64e714961c2025-08-20T03:18:15ZengWolters Kluwer Medknow PublicationsThe Arab Journal of Interventional Radiology2542-70752542-70832021-07-01050207608110.1055/s-0042-1742654Ablative Volume of Radiofrequency Ablation Related to Intrahepatic Recurrence-Free Survival of Hepatocellular CarcinomaNakarin Inmutto0Siripong Thaimai1Tanop Srisuwan2Thanate Kattipathanapong3Natthaphong Nimitrungtawee4Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandDepartment of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandDepartment of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandDepartment of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandDepartment of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandPurpose The aim of this study was to evaluate intrahepatic recurrence-free survival of hepatocellular carcinoma (HCC) after Radiofrequency ablation (RFA) Methods A retrospective cohort study of single HCC treated by RFA between 2015 and 2017. Fifty patients were enrolled in the study. Tumor volume and ablative volume were measured by using Syngo.via application (Siemen Healthineers, United States). Ablative volume classified into small and large ablative volumes. Ablative margin was evaluated by visual comparison between pre- and post-RFA images and classified into two groups: closed ablative margin (<0.5cm) and large ablative margin (>0.5 cm). The recurrence tumor was classified as local tumor progression (LTP) and intrahepatic distant recurrence (IDR). The recurrence-free survival rate and independent risk for tumor recurrence were analyzed. Results Recurrence-free survival rate at the first, second, third, and fourth year after RFA was 83, 56, 44, and 44%, respectively. The average recurrence-free survival time in large ablative volume group was significantly longer than small ablative volume group (31.57 vs. 8.50 months, p = 0.003). A significant independent risk factor for tumor recurrence was large ablative volume (hazard ratio = 0.12, 95% confidence interval = 0.02–0.84, p = 0.033). The IDR group had ratio of actual ablative volume by ideal ablative volume (ablative ratio) higher than LTP group and nonrecurrent group. Conclusion The large ablative volume prevented tumor recurrence and increased recurrence-free survival rate. But aggressive ablation with high ablative volume ratio could increase risk of IDR.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1742654hepatocellular carcinomaradiofrequency ablationrecurrence |
| spellingShingle | Nakarin Inmutto Siripong Thaimai Tanop Srisuwan Thanate Kattipathanapong Natthaphong Nimitrungtawee Ablative Volume of Radiofrequency Ablation Related to Intrahepatic Recurrence-Free Survival of Hepatocellular Carcinoma The Arab Journal of Interventional Radiology hepatocellular carcinoma radiofrequency ablation recurrence |
| title | Ablative Volume of Radiofrequency Ablation Related to Intrahepatic Recurrence-Free Survival of Hepatocellular Carcinoma |
| title_full | Ablative Volume of Radiofrequency Ablation Related to Intrahepatic Recurrence-Free Survival of Hepatocellular Carcinoma |
| title_fullStr | Ablative Volume of Radiofrequency Ablation Related to Intrahepatic Recurrence-Free Survival of Hepatocellular Carcinoma |
| title_full_unstemmed | Ablative Volume of Radiofrequency Ablation Related to Intrahepatic Recurrence-Free Survival of Hepatocellular Carcinoma |
| title_short | Ablative Volume of Radiofrequency Ablation Related to Intrahepatic Recurrence-Free Survival of Hepatocellular Carcinoma |
| title_sort | ablative volume of radiofrequency ablation related to intrahepatic recurrence free survival of hepatocellular carcinoma |
| topic | hepatocellular carcinoma radiofrequency ablation recurrence |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1742654 |
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