Antitumor effect of the Newcastle disease virus strain NDV/Altai/pigeon/777/2010 on a model of solid Lewis carcinoma
Aim. To evaluate the efficacy of intratumoral administrations of the Newcastle disease virus strain NDV/Altai/pigeon/777/2010, to compare progression of the tumor nodes after virotherapy and to analyse pathomorphological changes in the tumor tissue in vitro and in vivo. Single intratumoral injection...
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Kamerton
2024-10-01
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| Series: | Юг России: экология, развитие |
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| Online Access: | https://ecodag.elpub.ru/ugro/article/view/3220 |
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| author | Yu. I. Karkavin L. S. Adamenko K. S. Yurchenko A. V. Glushchenko |
| author_facet | Yu. I. Karkavin L. S. Adamenko K. S. Yurchenko A. V. Glushchenko |
| author_sort | Yu. I. Karkavin |
| collection | DOAJ |
| description | Aim. To evaluate the efficacy of intratumoral administrations of the Newcastle disease virus strain NDV/Altai/pigeon/777/2010, to compare progression of the tumor nodes after virotherapy and to analyse pathomorphological changes in the tumor tissue in vitro and in vivo. Single intratumoral injections of the mesogenic strain of Newcastle disease virus NDV/Altai/pigeon/777/2010, isolated from a rock dove in Siberia, were done into outbred mice of the C57Bl/6 line into solid nodes of Lewis lung carcinoma that were grafted subcutaneously. Then the dynamics of tumor growth and pathomorphological changes in the tumor tissue were assessed and analyzed.It was shown that single intratumoral injections into immunocompetent C57Bl/6 mice with the mesogenic strain of Newcastle disease virus NDV/Altai/pigeon/777/2010 led to an increase in peculiar pathomorphological changes in the tumor tissue of subcutaneously grafted Lewis lung carcinoma and to a decrease in tumor growth compared to the control group of mice in vivo. A direct cytotoxic effect of the NDV strain on the Vero E6 cell line in vitro was noted.The results of this study indicate that the NDV strain NDV/Altai/pigeon/777/2010 has antitumor properties. This may enable clinical trials to prove its effectiveness as an antitumor drug. |
| format | Article |
| id | doaj-art-df1ce71be2d6406c9386e3ec13289cba |
| institution | DOAJ |
| issn | 1992-1098 2413-0958 |
| language | Russian |
| publishDate | 2024-10-01 |
| publisher | Kamerton |
| record_format | Article |
| series | Юг России: экология, развитие |
| spelling | doaj-art-df1ce71be2d6406c9386e3ec13289cba2025-08-20T02:55:49ZrusKamertonЮг России: экология, развитие1992-10982413-09582024-10-01193445410.18470/1992-098-2024-3-41396Antitumor effect of the Newcastle disease virus strain NDV/Altai/pigeon/777/2010 on a model of solid Lewis carcinomaYu. I. Karkavin0L. S. Adamenko1K. S. Yurchenko2A. V. Glushchenko3Federal Research Centre of Fundamental and Translational Medicine (FRC FTM)Federal Research Centre of Fundamental and Translational Medicine (FRC FTM) ; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences (ICBFM SB RAS)Federal Research Centre of Fundamental and Translational Medicine (FRC FTM) ; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences (ICBFM SB RAS)Federal Research Centre of Fundamental and Translational Medicine (FRC FTM) ; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences (ICBFM SB RAS)Aim. To evaluate the efficacy of intratumoral administrations of the Newcastle disease virus strain NDV/Altai/pigeon/777/2010, to compare progression of the tumor nodes after virotherapy and to analyse pathomorphological changes in the tumor tissue in vitro and in vivo. Single intratumoral injections of the mesogenic strain of Newcastle disease virus NDV/Altai/pigeon/777/2010, isolated from a rock dove in Siberia, were done into outbred mice of the C57Bl/6 line into solid nodes of Lewis lung carcinoma that were grafted subcutaneously. Then the dynamics of tumor growth and pathomorphological changes in the tumor tissue were assessed and analyzed.It was shown that single intratumoral injections into immunocompetent C57Bl/6 mice with the mesogenic strain of Newcastle disease virus NDV/Altai/pigeon/777/2010 led to an increase in peculiar pathomorphological changes in the tumor tissue of subcutaneously grafted Lewis lung carcinoma and to a decrease in tumor growth compared to the control group of mice in vivo. A direct cytotoxic effect of the NDV strain on the Vero E6 cell line in vitro was noted.The results of this study indicate that the NDV strain NDV/Altai/pigeon/777/2010 has antitumor properties. This may enable clinical trials to prove its effectiveness as an antitumor drug.https://ecodag.elpub.ru/ugro/article/view/3220newcastle disease virusvirotherapylewis lung carcinomaoncolytic virusestumor progression |
| spellingShingle | Yu. I. Karkavin L. S. Adamenko K. S. Yurchenko A. V. Glushchenko Antitumor effect of the Newcastle disease virus strain NDV/Altai/pigeon/777/2010 on a model of solid Lewis carcinoma Юг России: экология, развитие newcastle disease virus virotherapy lewis lung carcinoma oncolytic viruses tumor progression |
| title | Antitumor effect of the Newcastle disease virus strain NDV/Altai/pigeon/777/2010 on a model of solid Lewis carcinoma |
| title_full | Antitumor effect of the Newcastle disease virus strain NDV/Altai/pigeon/777/2010 on a model of solid Lewis carcinoma |
| title_fullStr | Antitumor effect of the Newcastle disease virus strain NDV/Altai/pigeon/777/2010 on a model of solid Lewis carcinoma |
| title_full_unstemmed | Antitumor effect of the Newcastle disease virus strain NDV/Altai/pigeon/777/2010 on a model of solid Lewis carcinoma |
| title_short | Antitumor effect of the Newcastle disease virus strain NDV/Altai/pigeon/777/2010 on a model of solid Lewis carcinoma |
| title_sort | antitumor effect of the newcastle disease virus strain ndv altai pigeon 777 2010 on a model of solid lewis carcinoma |
| topic | newcastle disease virus virotherapy lewis lung carcinoma oncolytic viruses tumor progression |
| url | https://ecodag.elpub.ru/ugro/article/view/3220 |
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