Antimicrobial Smart Dressings for Combating Antibiotic Resistance in Wound Care
Wound healing is a complex, tightly regulated process essential for maintaining skin barrier function. Chronic wounds, often complicated by biofilm-forming bacteria and elevated oxidative stress, pose significant challenges in clinical management. The rise of antibiotic-resistant bacteria has furthe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-05-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/18/6/825 |
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| author | Alina-Georgiana Cristea (Hohotă) Elena-Lăcrămioara Lisă Simona Iacob (Ciobotaru) Ionut Dragostin Claudia Simona Ștefan Iuliu Fulga Andra Monica Anghel (Ștefan) Maria Dragan Ionela Daniela Morariu Oana-Maria Dragostin |
| author_facet | Alina-Georgiana Cristea (Hohotă) Elena-Lăcrămioara Lisă Simona Iacob (Ciobotaru) Ionut Dragostin Claudia Simona Ștefan Iuliu Fulga Andra Monica Anghel (Ștefan) Maria Dragan Ionela Daniela Morariu Oana-Maria Dragostin |
| author_sort | Alina-Georgiana Cristea (Hohotă) |
| collection | DOAJ |
| description | Wound healing is a complex, tightly regulated process essential for maintaining skin barrier function. Chronic wounds, often complicated by biofilm-forming bacteria and elevated oxidative stress, pose significant challenges in clinical management. The rise of antibiotic-resistant bacteria has further exacerbated the problem, limiting therapeutic options and complicating wound treatment. Traditional wound care approaches frequently fail to provide real-time accurate insights into wound status, leading to delayed or suboptimal treatments. Recent advancements in modern and smart wound dressings, which integrate various biosensors, different new drug delivery systems, and wireless communication technology, offers promising solutions for monitoring wound progression over time. These innovations enable early detection of adverse events such as bacterial infections and inflammation, facilitating more effective, on-demand treatment. This review highlights the current state of antibiotic-embedded wound dressings, discusses their limitations, and explores the potential of next-generation wound dressings incorporating microelectronic sensors for real-time monitoring and adaptive therapeutic responses to support healing and combat antimicrobial resistance. |
| format | Article |
| id | doaj-art-df18bd28ce1f43bc85016759a83bd822 |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-df18bd28ce1f43bc85016759a83bd8222025-08-20T03:27:32ZengMDPI AGPharmaceuticals1424-82472025-05-0118682510.3390/ph18060825Antimicrobial Smart Dressings for Combating Antibiotic Resistance in Wound CareAlina-Georgiana Cristea (Hohotă)0Elena-Lăcrămioara Lisă1Simona Iacob (Ciobotaru)2Ionut Dragostin3Claudia Simona Ștefan4Iuliu Fulga5Andra Monica Anghel (Ștefan)6Maria Dragan7Ionela Daniela Morariu8Oana-Maria Dragostin9Research Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University, 800201 Galati, RomaniaResearch Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University, 800201 Galati, RomaniaResearch Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University, 800201 Galati, RomaniaResearch Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University, 800201 Galati, RomaniaResearch Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University, 800201 Galati, RomaniaResearch Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University, 800201 Galati, RomaniaResearch Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University, 800201 Galati, RomaniaDepartment of Pharmaceutical Sciences II, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Environmental and Food Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaResearch Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University, 800201 Galati, RomaniaWound healing is a complex, tightly regulated process essential for maintaining skin barrier function. Chronic wounds, often complicated by biofilm-forming bacteria and elevated oxidative stress, pose significant challenges in clinical management. The rise of antibiotic-resistant bacteria has further exacerbated the problem, limiting therapeutic options and complicating wound treatment. Traditional wound care approaches frequently fail to provide real-time accurate insights into wound status, leading to delayed or suboptimal treatments. Recent advancements in modern and smart wound dressings, which integrate various biosensors, different new drug delivery systems, and wireless communication technology, offers promising solutions for monitoring wound progression over time. These innovations enable early detection of adverse events such as bacterial infections and inflammation, facilitating more effective, on-demand treatment. This review highlights the current state of antibiotic-embedded wound dressings, discusses their limitations, and explores the potential of next-generation wound dressings incorporating microelectronic sensors for real-time monitoring and adaptive therapeutic responses to support healing and combat antimicrobial resistance.https://www.mdpi.com/1424-8247/18/6/825antimicrobialswound infectionantimicrobial resistancewound dressings |
| spellingShingle | Alina-Georgiana Cristea (Hohotă) Elena-Lăcrămioara Lisă Simona Iacob (Ciobotaru) Ionut Dragostin Claudia Simona Ștefan Iuliu Fulga Andra Monica Anghel (Ștefan) Maria Dragan Ionela Daniela Morariu Oana-Maria Dragostin Antimicrobial Smart Dressings for Combating Antibiotic Resistance in Wound Care Pharmaceuticals antimicrobials wound infection antimicrobial resistance wound dressings |
| title | Antimicrobial Smart Dressings for Combating Antibiotic Resistance in Wound Care |
| title_full | Antimicrobial Smart Dressings for Combating Antibiotic Resistance in Wound Care |
| title_fullStr | Antimicrobial Smart Dressings for Combating Antibiotic Resistance in Wound Care |
| title_full_unstemmed | Antimicrobial Smart Dressings for Combating Antibiotic Resistance in Wound Care |
| title_short | Antimicrobial Smart Dressings for Combating Antibiotic Resistance in Wound Care |
| title_sort | antimicrobial smart dressings for combating antibiotic resistance in wound care |
| topic | antimicrobials wound infection antimicrobial resistance wound dressings |
| url | https://www.mdpi.com/1424-8247/18/6/825 |
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