Comprehensive analyses of telomerase component DKC1 and its association with clinical, molecular and immune landscapes in uterine corpus endometrial carcinoma

Comprehensive analyses of telomerase component DKC1 and its association with clinical, molecular and immune landscapes in uterine corpus endometrial carcinoma

BackgroundTelomerase activation is essential to malignant transformation and progression including uterine corpus endometrial carcinoma (UCEC), while telomerase co-factor DKC1-mediated RNA pseudouridylation is required for functional telomerase by stabilizing telomerase RNA component (TERC) and its...

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Bibliographic Details
Main Authors: Chenxi Sun, Xu Liu, Tiantian Liu, Chenliu Fan, Yang Jiang, Binggen Li, Huiyang Yuan, Chengyun Zheng, Dawei Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
DKC1
endometrial carcinoma
prognostic factor
tumor microenvironment
T Cell exclusion
telomerase
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1592135/full
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