Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds
Dextran/Sulfodextran-graft-polyacrylamide- and polyacrylamide-based hydrogels were synthesized by radical polymerization and loaded with cefuroxime to obtain antimicrobial wound dressings. Antibiotic release from the antibiotic-loaded hydrogels into an aqueous solution was studied by the HPLC-UV met...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2021/4935642 |
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| _version_ | 1850167923507724288 |
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| author | Pavlo Virych Oksana Nadtoka Volodymyr Doroschuk Sergey Lelyushok Vasyl Chumachenko Tetiana Bezugla Nataliya Kutsevol |
| author_facet | Pavlo Virych Oksana Nadtoka Volodymyr Doroschuk Sergey Lelyushok Vasyl Chumachenko Tetiana Bezugla Nataliya Kutsevol |
| author_sort | Pavlo Virych |
| collection | DOAJ |
| description | Dextran/Sulfodextran-graft-polyacrylamide- and polyacrylamide-based hydrogels were synthesized by radical polymerization and loaded with cefuroxime to obtain antimicrobial wound dressings. Antibiotic release from the antibiotic-loaded hydrogels into an aqueous solution was studied by the HPLC-UV method. It is shown that cefuroxime-loaded Dextran/Sulfodextran-graft-polyacrylamide hydrogels release the antibiotic more slowly compared to polyacrylamide hydrogel with the same density of cross-links. Antibacterial activity of the synthesized materials was tested in vitro against wild strains of S. aureus, E. coli, and Klebsiella spp. The possibility of using the obtained antimicrobial hydrogels for the treatment of infected wounds was confirmed in vivo in a rat model. |
| format | Article |
| id | doaj-art-df0d8889df8e481c8a575c6b930878ea |
| institution | OA Journals |
| issn | 1687-9430 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-df0d8889df8e481c8a575c6b930878ea2025-08-20T02:21:06ZengWileyInternational Journal of Polymer Science1687-94302021-01-01202110.1155/2021/4935642Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open WoundsPavlo Virych0Oksana Nadtoka1Volodymyr Doroschuk2Sergey Lelyushok3Vasyl Chumachenko4Tetiana Bezugla5Nataliya Kutsevol6Taras Shevchenko National University of KyivTaras Shevchenko National University of KyivTaras Shevchenko National University of KyivTaras Shevchenko National University of KyivTaras Shevchenko National University of KyivTaras Shevchenko National University of KyivTaras Shevchenko National University of KyivDextran/Sulfodextran-graft-polyacrylamide- and polyacrylamide-based hydrogels were synthesized by radical polymerization and loaded with cefuroxime to obtain antimicrobial wound dressings. Antibiotic release from the antibiotic-loaded hydrogels into an aqueous solution was studied by the HPLC-UV method. It is shown that cefuroxime-loaded Dextran/Sulfodextran-graft-polyacrylamide hydrogels release the antibiotic more slowly compared to polyacrylamide hydrogel with the same density of cross-links. Antibacterial activity of the synthesized materials was tested in vitro against wild strains of S. aureus, E. coli, and Klebsiella spp. The possibility of using the obtained antimicrobial hydrogels for the treatment of infected wounds was confirmed in vivo in a rat model.http://dx.doi.org/10.1155/2021/4935642 |
| spellingShingle | Pavlo Virych Oksana Nadtoka Volodymyr Doroschuk Sergey Lelyushok Vasyl Chumachenko Tetiana Bezugla Nataliya Kutsevol Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds International Journal of Polymer Science |
| title | Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds |
| title_full | Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds |
| title_fullStr | Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds |
| title_full_unstemmed | Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds |
| title_short | Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds |
| title_sort | cefuroxime loaded hydrogels for prevention and treatment of bacterial contamination of open wounds |
| url | http://dx.doi.org/10.1155/2021/4935642 |
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