Exploring the link between estimated glucose disposal rate and Parkinson’s disease: cross-sectional and mortality analysis of NHANES 2003–2016
ObjectivesTo investigate the association between estimated glucose disposal rate (eGDR), a surrogate marker of insulin resistance, and Parkinson’s disease (PD) risk, and to examine the relationship between eGDR and all-cause mortality among PD patients.MethodsUsing data from the National Health and...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1548020/full |
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| author | Xiaoting Li Zhaohao Zeng Zhaohao Zeng |
| author_facet | Xiaoting Li Zhaohao Zeng Zhaohao Zeng |
| author_sort | Xiaoting Li |
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| description | ObjectivesTo investigate the association between estimated glucose disposal rate (eGDR), a surrogate marker of insulin resistance, and Parkinson’s disease (PD) risk, and to examine the relationship between eGDR and all-cause mortality among PD patients.MethodsUsing data from the National Health and Nutrition Examination Survey (NHANES) 2003–2016, we conducted a cross-sectional study of 20,767 participants aged ≥40 years. eGDR was calculated using waist circumference, hypertension status, and HbA1c levels. PD cases were identified through anti-parkinsonian medication use. The association between eGDR and PD was examined using weighted logistic regression models with progressive adjustment for potential confounders. Survival analysis was performed in 255 PD patients to assess the relationship between eGDR and all-cause mortality.ResultsAmong participants, 256 had PD (weighted prevalence: 1.23%). Higher eGDR was associated with lower odds of PD in crude analysis (OR: 0.906, 95% CI: 0.856–0.960, P < 0.001). After full adjustment, the highest eGDR tertile showed significantly lower odds of PD compared to the lowest tertile (OR: 0.574, 95% CI: 0.337–0.976, P = 0.040). Restricted cubic spline analysis revealed a significant M-shaped non-linear relationship between eGDR and PD risk (P for non-linearity < 0.001). In survival analysis, higher eGDR was associated with lower mortality risk (adjusted HR: 0.875, 95% CI: 0.775–0.987, P = 0.030), with an inverted U-shaped relationship observed (P for non-linearity = 0.0352).ConclusionHigher eGDR levels are associated with lower PD risk and better survival in PD patients, suggesting that insulin sensitivity might play a role in PD pathogenesis and progression. These findings highlight the potential importance of metabolic health in PD. |
| format | Article |
| id | doaj-art-df07d5eb9d854f9f8c12f020dd968d24 |
| institution | DOAJ |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-df07d5eb9d854f9f8c12f020dd968d242025-08-20T03:05:43ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-04-011710.3389/fnagi.2025.15480201548020Exploring the link between estimated glucose disposal rate and Parkinson’s disease: cross-sectional and mortality analysis of NHANES 2003–2016Xiaoting Li0Zhaohao Zeng1Zhaohao Zeng2Department of Neurology, Panyu Hexian Memorial Affiliated Hospital of Guangzhou, Guangzhou, ChinaDepartment of Neurology, Shenzhen People’s Hospital (The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University), Shenzhen, Guangdong, ChinaGuangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, ChinaObjectivesTo investigate the association between estimated glucose disposal rate (eGDR), a surrogate marker of insulin resistance, and Parkinson’s disease (PD) risk, and to examine the relationship between eGDR and all-cause mortality among PD patients.MethodsUsing data from the National Health and Nutrition Examination Survey (NHANES) 2003–2016, we conducted a cross-sectional study of 20,767 participants aged ≥40 years. eGDR was calculated using waist circumference, hypertension status, and HbA1c levels. PD cases were identified through anti-parkinsonian medication use. The association between eGDR and PD was examined using weighted logistic regression models with progressive adjustment for potential confounders. Survival analysis was performed in 255 PD patients to assess the relationship between eGDR and all-cause mortality.ResultsAmong participants, 256 had PD (weighted prevalence: 1.23%). Higher eGDR was associated with lower odds of PD in crude analysis (OR: 0.906, 95% CI: 0.856–0.960, P < 0.001). After full adjustment, the highest eGDR tertile showed significantly lower odds of PD compared to the lowest tertile (OR: 0.574, 95% CI: 0.337–0.976, P = 0.040). Restricted cubic spline analysis revealed a significant M-shaped non-linear relationship between eGDR and PD risk (P for non-linearity < 0.001). In survival analysis, higher eGDR was associated with lower mortality risk (adjusted HR: 0.875, 95% CI: 0.775–0.987, P = 0.030), with an inverted U-shaped relationship observed (P for non-linearity = 0.0352).ConclusionHigher eGDR levels are associated with lower PD risk and better survival in PD patients, suggesting that insulin sensitivity might play a role in PD pathogenesis and progression. These findings highlight the potential importance of metabolic health in PD.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1548020/fullParkinson’s diseaseestimated glucose disposal rateinsulin resistanceNHANESall-cause mortality |
| spellingShingle | Xiaoting Li Zhaohao Zeng Zhaohao Zeng Exploring the link between estimated glucose disposal rate and Parkinson’s disease: cross-sectional and mortality analysis of NHANES 2003–2016 Frontiers in Aging Neuroscience Parkinson’s disease estimated glucose disposal rate insulin resistance NHANES all-cause mortality |
| title | Exploring the link between estimated glucose disposal rate and Parkinson’s disease: cross-sectional and mortality analysis of NHANES 2003–2016 |
| title_full | Exploring the link between estimated glucose disposal rate and Parkinson’s disease: cross-sectional and mortality analysis of NHANES 2003–2016 |
| title_fullStr | Exploring the link between estimated glucose disposal rate and Parkinson’s disease: cross-sectional and mortality analysis of NHANES 2003–2016 |
| title_full_unstemmed | Exploring the link between estimated glucose disposal rate and Parkinson’s disease: cross-sectional and mortality analysis of NHANES 2003–2016 |
| title_short | Exploring the link between estimated glucose disposal rate and Parkinson’s disease: cross-sectional and mortality analysis of NHANES 2003–2016 |
| title_sort | exploring the link between estimated glucose disposal rate and parkinson s disease cross sectional and mortality analysis of nhanes 2003 2016 |
| topic | Parkinson’s disease estimated glucose disposal rate insulin resistance NHANES all-cause mortality |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1548020/full |
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