The transition of the criteria for disseminated intravascular coagulation and the targeted patients in randomized controlled trials over the decades: a scoping review
Abstract Background Disseminated intravascular coagulation (DIC) is a severe complication in septic patients. The Japanese Ministry of Health and Welfare (JMHW)-DIC criteria, the first DIC criteria, were established in 1983, and several other criteria have been proposed since then, including the Int...
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2024-12-01
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| Online Access: | https://doi.org/10.1186/s12959-024-00681-w |
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| author | Tadashi Matsuoka Kazuma Yamakawa Yutaka Umemura Koichiro Homma Toshiaki Iba Junichi Sasaki |
| author_facet | Tadashi Matsuoka Kazuma Yamakawa Yutaka Umemura Koichiro Homma Toshiaki Iba Junichi Sasaki |
| author_sort | Tadashi Matsuoka |
| collection | DOAJ |
| description | Abstract Background Disseminated intravascular coagulation (DIC) is a severe complication in septic patients. The Japanese Ministry of Health and Welfare (JMHW)-DIC criteria, the first DIC criteria, were established in 1983, and several other criteria have been proposed since then, including the International Society on Thrombosis and Haemostasis (ISTH)-overt DIC criteria and the Japanese Association for Acute Medicine (JAAM) DIC criteria. This study aimed to look into the transition of DIC criteria used in randomized controlled trials (RCTs) for sepsis-induced DIC. Methods We searched PubMed, Scopus, and the Cochrane Central Register of Controlled Trials for English-language studies published through September 30, 2023. Two reviewers looked through citations that assessed the DIC criteria used in RCTs and their secondary analyses. Data on DIC diagnostic criteria, patient characteristics, interventions, and results were gathered. Results Twenty-one studies (thirteen RCTs: JMHW-DIC in 5, JAAM-DIC in 4, the sepsis-induced coagulopathy (SIC) in 2; and eight secondary analyses: ISTH-overt DIC in 3, single parameter in 5) were eligible for inclusion. Most RCTs were conducted in Japan, using the criteria of JMHW-DIC, which were followed by JAAM-DIC. Recently, SIC has been used in international RCTs. Meanwhile, other countries tended to conduct RCTs that focused on sepsis, with secondary analyses for DIC using the ISTH-overt DIC criteria. Conclusions The criteria used in RCTs have changed over decades, from the JMHW-DIC to the JAAM-DIC criteria, and the ISTH-overt DIC criteria were retained in the secondary analysis. Based on these findings, additional research is needed to determine the best criterion for diagnosing septic patients. |
| format | Article |
| id | doaj-art-df034e7f98294b5e893097a14562a5d0 |
| institution | DOAJ |
| issn | 1477-9560 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj-art-df034e7f98294b5e893097a14562a5d02025-08-20T02:43:25ZengBMCThrombosis Journal1477-95602024-12-0122111110.1186/s12959-024-00681-wThe transition of the criteria for disseminated intravascular coagulation and the targeted patients in randomized controlled trials over the decades: a scoping reviewTadashi Matsuoka0Kazuma Yamakawa1Yutaka Umemura2Koichiro Homma3Toshiaki Iba4Junichi Sasaki5Department of Emergency and Critical Care Medicine, Keio UniversityDepartment of Emergency and Critical Care Medicine, Osaka Medical and Pharmaceutical UniversityDivision of Trauma and Surgical Critical Care, Osaka General Medical CenterDepartment of Emergency and Critical Care Medicine, Keio UniversityDepartment of Emergency and Disaster Medicine, Juntendo University Graduate School of MedicineDepartment of Emergency and Critical Care Medicine, Keio UniversityAbstract Background Disseminated intravascular coagulation (DIC) is a severe complication in septic patients. The Japanese Ministry of Health and Welfare (JMHW)-DIC criteria, the first DIC criteria, were established in 1983, and several other criteria have been proposed since then, including the International Society on Thrombosis and Haemostasis (ISTH)-overt DIC criteria and the Japanese Association for Acute Medicine (JAAM) DIC criteria. This study aimed to look into the transition of DIC criteria used in randomized controlled trials (RCTs) for sepsis-induced DIC. Methods We searched PubMed, Scopus, and the Cochrane Central Register of Controlled Trials for English-language studies published through September 30, 2023. Two reviewers looked through citations that assessed the DIC criteria used in RCTs and their secondary analyses. Data on DIC diagnostic criteria, patient characteristics, interventions, and results were gathered. Results Twenty-one studies (thirteen RCTs: JMHW-DIC in 5, JAAM-DIC in 4, the sepsis-induced coagulopathy (SIC) in 2; and eight secondary analyses: ISTH-overt DIC in 3, single parameter in 5) were eligible for inclusion. Most RCTs were conducted in Japan, using the criteria of JMHW-DIC, which were followed by JAAM-DIC. Recently, SIC has been used in international RCTs. Meanwhile, other countries tended to conduct RCTs that focused on sepsis, with secondary analyses for DIC using the ISTH-overt DIC criteria. Conclusions The criteria used in RCTs have changed over decades, from the JMHW-DIC to the JAAM-DIC criteria, and the ISTH-overt DIC criteria were retained in the secondary analysis. Based on these findings, additional research is needed to determine the best criterion for diagnosing septic patients.https://doi.org/10.1186/s12959-024-00681-wDisseminated intravascular coagulationSepsisAnticoagulant therapyDiagnostic criteria. |
| spellingShingle | Tadashi Matsuoka Kazuma Yamakawa Yutaka Umemura Koichiro Homma Toshiaki Iba Junichi Sasaki The transition of the criteria for disseminated intravascular coagulation and the targeted patients in randomized controlled trials over the decades: a scoping review Thrombosis Journal Disseminated intravascular coagulation Sepsis Anticoagulant therapy Diagnostic criteria. |
| title | The transition of the criteria for disseminated intravascular coagulation and the targeted patients in randomized controlled trials over the decades: a scoping review |
| title_full | The transition of the criteria for disseminated intravascular coagulation and the targeted patients in randomized controlled trials over the decades: a scoping review |
| title_fullStr | The transition of the criteria for disseminated intravascular coagulation and the targeted patients in randomized controlled trials over the decades: a scoping review |
| title_full_unstemmed | The transition of the criteria for disseminated intravascular coagulation and the targeted patients in randomized controlled trials over the decades: a scoping review |
| title_short | The transition of the criteria for disseminated intravascular coagulation and the targeted patients in randomized controlled trials over the decades: a scoping review |
| title_sort | transition of the criteria for disseminated intravascular coagulation and the targeted patients in randomized controlled trials over the decades a scoping review |
| topic | Disseminated intravascular coagulation Sepsis Anticoagulant therapy Diagnostic criteria. |
| url | https://doi.org/10.1186/s12959-024-00681-w |
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