Syringic Acid Attenuates Cardiomyopathy in Streptozotocin-Induced Diabetic Rats
Objectives. Diabetic cardiomyopathy (DC) has become one of the serious complications in diabetic cases. In this study, we aimed to explore the syringic acid (SYR) protective effect against diabetes-induced cardiac injury in experimental rats. Methods. Rats were divided in control and streptozotocin-...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Advances in Pharmacological and Pharmaceutical Sciences |
| Online Access: | http://dx.doi.org/10.1155/2021/5018092 |
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| author | Zahra Sabahi Mohammad Javad Khoshnoud Sara Hosseini Fatemeh Khoshraftar Marzieh Rashedinia |
| author_facet | Zahra Sabahi Mohammad Javad Khoshnoud Sara Hosseini Fatemeh Khoshraftar Marzieh Rashedinia |
| author_sort | Zahra Sabahi |
| collection | DOAJ |
| description | Objectives. Diabetic cardiomyopathy (DC) has become one of the serious complications in diabetic cases. In this study, we aimed to explore the syringic acid (SYR) protective effect against diabetes-induced cardiac injury in experimental rats. Methods. Rats were divided in control and streptozotocin-induced diabetic rats which were subdivided into diabetic controls, and three test groups (SYR at 25, 50, and 100 mg/kg) and the nondiabetic group received 100 mg/kg of SYR. All treatments were given SYR for 6 weeks. SYR effects on cardiac diagnostic markers, heart lipid peroxidation, protein carbonylation, antioxidant system, and changes of the heart mitochondrial mass and biogenesis were measured. Results. Diabetes induction prompted CK-MB, LDH levels in serum, cardiac catalase, and superoxide dismutase activity, as well as cardiac TBARs and carbonylated protein. SYR administration (100 m/kg) attenuated CK-MB and LDH levels. Also, 50 and 100 mg/kg of SYR reduced cardiac TBARs and carbonylated protein in diabetic rats. These treatments did not show any effects on GSH content, mtDNA, and mitochondrial biogenesis indices (PGC1- α, NRF1, NRF2, and TFAM) in heart tissue. Conclusions. SYR treatment showed protective effects on diabetic cardiomyopathy in rats by reducing lipid peroxidation and protein carbonylation. The possible mechanisms could be related to antioxidant activity of this phenolic acid. SYR might play a role of a protective factor in cardiac challenges in diabetes. |
| format | Article |
| id | doaj-art-defcc2d45c38438b823acaf94e4011bc |
| institution | OA Journals |
| issn | 2633-4690 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological and Pharmaceutical Sciences |
| spelling | doaj-art-defcc2d45c38438b823acaf94e4011bc2025-08-20T02:21:06ZengWileyAdvances in Pharmacological and Pharmaceutical Sciences2633-46902021-01-01202110.1155/2021/5018092Syringic Acid Attenuates Cardiomyopathy in Streptozotocin-Induced Diabetic RatsZahra Sabahi0Mohammad Javad Khoshnoud1Sara Hosseini2Fatemeh Khoshraftar3Marzieh Rashedinia4Medicinal Plants Processing Research CenterFood and Supplements Research CenterDepartment of Pharmacology and ToxicologyDepartment of Pharmacology and ToxicologyMedicinal Plants Processing Research CenterObjectives. Diabetic cardiomyopathy (DC) has become one of the serious complications in diabetic cases. In this study, we aimed to explore the syringic acid (SYR) protective effect against diabetes-induced cardiac injury in experimental rats. Methods. Rats were divided in control and streptozotocin-induced diabetic rats which were subdivided into diabetic controls, and three test groups (SYR at 25, 50, and 100 mg/kg) and the nondiabetic group received 100 mg/kg of SYR. All treatments were given SYR for 6 weeks. SYR effects on cardiac diagnostic markers, heart lipid peroxidation, protein carbonylation, antioxidant system, and changes of the heart mitochondrial mass and biogenesis were measured. Results. Diabetes induction prompted CK-MB, LDH levels in serum, cardiac catalase, and superoxide dismutase activity, as well as cardiac TBARs and carbonylated protein. SYR administration (100 m/kg) attenuated CK-MB and LDH levels. Also, 50 and 100 mg/kg of SYR reduced cardiac TBARs and carbonylated protein in diabetic rats. These treatments did not show any effects on GSH content, mtDNA, and mitochondrial biogenesis indices (PGC1- α, NRF1, NRF2, and TFAM) in heart tissue. Conclusions. SYR treatment showed protective effects on diabetic cardiomyopathy in rats by reducing lipid peroxidation and protein carbonylation. The possible mechanisms could be related to antioxidant activity of this phenolic acid. SYR might play a role of a protective factor in cardiac challenges in diabetes.http://dx.doi.org/10.1155/2021/5018092 |
| spellingShingle | Zahra Sabahi Mohammad Javad Khoshnoud Sara Hosseini Fatemeh Khoshraftar Marzieh Rashedinia Syringic Acid Attenuates Cardiomyopathy in Streptozotocin-Induced Diabetic Rats Advances in Pharmacological and Pharmaceutical Sciences |
| title | Syringic Acid Attenuates Cardiomyopathy in Streptozotocin-Induced Diabetic Rats |
| title_full | Syringic Acid Attenuates Cardiomyopathy in Streptozotocin-Induced Diabetic Rats |
| title_fullStr | Syringic Acid Attenuates Cardiomyopathy in Streptozotocin-Induced Diabetic Rats |
| title_full_unstemmed | Syringic Acid Attenuates Cardiomyopathy in Streptozotocin-Induced Diabetic Rats |
| title_short | Syringic Acid Attenuates Cardiomyopathy in Streptozotocin-Induced Diabetic Rats |
| title_sort | syringic acid attenuates cardiomyopathy in streptozotocin induced diabetic rats |
| url | http://dx.doi.org/10.1155/2021/5018092 |
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