Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice
Paracetamol, chemically known as acetaminophen, if taken in higher doses has hepatotoxic potential. Cimetidine by inhibiting the cytochromal enzymes and reducing the production of the toxic metabolite can reduce the hepatotoxic potential while Verapamil can act as a hepatoprotective by maintaining c...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2020/9185361 |
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| author | Lubna Danish Riffat Siddiq Sarwat Jahan Mehwish Taneez Manzoor Khan Marva Sandhu |
| author_facet | Lubna Danish Riffat Siddiq Sarwat Jahan Mehwish Taneez Manzoor Khan Marva Sandhu |
| author_sort | Lubna Danish |
| collection | DOAJ |
| description | Paracetamol, chemically known as acetaminophen, if taken in higher doses has hepatotoxic potential. Cimetidine by inhibiting the cytochromal enzymes and reducing the production of the toxic metabolite can reduce the hepatotoxic potential while Verapamil can act as a hepatoprotective by maintaining calcium homeostasis. The present study was conducted to study the hepatoprotective activity of Cimetidine and Verapamil against the toxicity induced by paracetamol. In addition to the group receiving only distilled water or 300 mg/kg paracetamol additional groups were added treated with 150 mg/kg Cimetidine and Verapamil alone or both. The Liver function tests and histopathology revealed hepatotoxicity in the group receiving paracetamol (PCM) while normal parameters were observed in the groups receiving Cimetidine and Verapamil. Our results strongly suggested that Cimetidine and Verapamil possess hepatoprotective potential against paracetamol induced hepatotoxicity. |
| format | Article |
| id | doaj-art-def202d51e1a4c6aa7732673601667f3 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-def202d51e1a4c6aa7732673601667f32025-02-03T00:58:40ZengWileyInternational Journal of Hepatology2090-34482090-34562020-01-01202010.1155/2020/91853619185361Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in MiceLubna Danish0Riffat Siddiq1Sarwat Jahan2Mehwish Taneez3Manzoor Khan4Marva Sandhu5Sulaiman Bin Abdullah Aba Al-Khail Centre for Interdisciplinary Research in Basic Sciences (CIRBS), International Islamic University Islamabad (IIUI), Islamabad, PakistanDepartment of Maxillofacial Surgery, Rehman College of Dentistry, Peshawar, PakistanNorthwest School of Medicine, Phase-V Hayatabad, Peshawar, PakistanSulaiman Bin Abdullah Aba Al-Khail Centre for Interdisciplinary Research in Basic Sciences (CIRBS), International Islamic University Islamabad (IIUI), Islamabad, PakistanDepartment of Medicine, Khyber Teaching Hospital, Peshawar, PakistanDepartment of Pharmacology, National Institute of Health (NIH), Islamabad, PakistanParacetamol, chemically known as acetaminophen, if taken in higher doses has hepatotoxic potential. Cimetidine by inhibiting the cytochromal enzymes and reducing the production of the toxic metabolite can reduce the hepatotoxic potential while Verapamil can act as a hepatoprotective by maintaining calcium homeostasis. The present study was conducted to study the hepatoprotective activity of Cimetidine and Verapamil against the toxicity induced by paracetamol. In addition to the group receiving only distilled water or 300 mg/kg paracetamol additional groups were added treated with 150 mg/kg Cimetidine and Verapamil alone or both. The Liver function tests and histopathology revealed hepatotoxicity in the group receiving paracetamol (PCM) while normal parameters were observed in the groups receiving Cimetidine and Verapamil. Our results strongly suggested that Cimetidine and Verapamil possess hepatoprotective potential against paracetamol induced hepatotoxicity.http://dx.doi.org/10.1155/2020/9185361 |
| spellingShingle | Lubna Danish Riffat Siddiq Sarwat Jahan Mehwish Taneez Manzoor Khan Marva Sandhu Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice International Journal of Hepatology |
| title | Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice |
| title_full | Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice |
| title_fullStr | Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice |
| title_full_unstemmed | Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice |
| title_short | Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice |
| title_sort | comparative study of protective effect of cimetidine and verapamil on paracetamol induced hepatotoxicity in mice |
| url | http://dx.doi.org/10.1155/2020/9185361 |
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