The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice
<b>Background/Objectives.</b> Chronic wounds pose a substantial global healthcare burden exacerbated by aging populations and the increasing prevalence of conditions such as diabetes, peripheral vascular disease, and venous insufficiency. Impaired physiological repair mechanisms, includi...
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MDPI AG
2025-02-01
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| author | Gadi Borkow Eyal Melamed |
| author_facet | Gadi Borkow Eyal Melamed |
| author_sort | Gadi Borkow |
| collection | DOAJ |
| description | <b>Background/Objectives.</b> Chronic wounds pose a substantial global healthcare burden exacerbated by aging populations and the increasing prevalence of conditions such as diabetes, peripheral vascular disease, and venous insufficiency. Impaired physiological repair mechanisms, including angiogenesis, collagen synthesis, and re-epithelialization, hinder the healing process in chronic wounds. Many of these physiological processes are dependent on their interaction with copper. We hypothesized that the targeted delivery of copper ions to the wound bed would enhance healing. <b>Methods.</b> Wound dressings impregnated with copper oxide microparticles were designed to ensure the controlled release of copper ions. The efficacy of these dressings was evaluated using non-infected wound models, including diabetic mouse models compared against control and silver dressings. Outcome measures included wound closure rates, epidermal skin quality assessed by histopathological examination, and gene expression profiling. Clinical applications were assessed through diverse case studies and controlled trials involving chronic wound management. <b>Results.</b> Copper dressings significantly accelerated wound closure and enhanced angiogenesis compared to control and silver dressings. Histopathological analyses revealed faster granulation tissue formation, epidermal regeneration, and neovascularization. Gene expression studies showed upregulation of critical angiogenic factors such as VEGF and HIF-1α. Investigations and clinical observations corroborated improved healing across various chronic wound types, including non-infected wounds. <b>Conclusions.</b> Copper is essential for wound healing, and copper-impregnated dressings provide a promising solution for chronic wound management. By enhancing angiogenesis and tissue regeneration, these dressings go beyond antimicrobial action, offering a cost-effective and innovative alternative to conventional therapies. Copper dressings represent a transformative advancement in addressing the challenges of chronic wound care. |
| format | Article |
| id | doaj-art-deef04d7fe9d470e8e0631bd8c1f62ef |
| institution | OA Journals |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-deef04d7fe9d470e8e0631bd8c1f62ef2025-08-20T02:11:04ZengMDPI AGBiomedicines2227-90592025-02-0113356210.3390/biomedicines13030562The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical PracticeGadi Borkow0Eyal Melamed1MedCu Technologies Ltd., Herzliya 4672200, IsraelFoot and Ankle Service, Department of Orthopedics, Bnai Zion Medical Center, Haifa 3109601, Israel<b>Background/Objectives.</b> Chronic wounds pose a substantial global healthcare burden exacerbated by aging populations and the increasing prevalence of conditions such as diabetes, peripheral vascular disease, and venous insufficiency. Impaired physiological repair mechanisms, including angiogenesis, collagen synthesis, and re-epithelialization, hinder the healing process in chronic wounds. Many of these physiological processes are dependent on their interaction with copper. We hypothesized that the targeted delivery of copper ions to the wound bed would enhance healing. <b>Methods.</b> Wound dressings impregnated with copper oxide microparticles were designed to ensure the controlled release of copper ions. The efficacy of these dressings was evaluated using non-infected wound models, including diabetic mouse models compared against control and silver dressings. Outcome measures included wound closure rates, epidermal skin quality assessed by histopathological examination, and gene expression profiling. Clinical applications were assessed through diverse case studies and controlled trials involving chronic wound management. <b>Results.</b> Copper dressings significantly accelerated wound closure and enhanced angiogenesis compared to control and silver dressings. Histopathological analyses revealed faster granulation tissue formation, epidermal regeneration, and neovascularization. Gene expression studies showed upregulation of critical angiogenic factors such as VEGF and HIF-1α. Investigations and clinical observations corroborated improved healing across various chronic wound types, including non-infected wounds. <b>Conclusions.</b> Copper is essential for wound healing, and copper-impregnated dressings provide a promising solution for chronic wound management. By enhancing angiogenesis and tissue regeneration, these dressings go beyond antimicrobial action, offering a cost-effective and innovative alternative to conventional therapies. Copper dressings represent a transformative advancement in addressing the challenges of chronic wound care.https://www.mdpi.com/2227-9059/13/3/562copper oxidewound dressingswound healingangiogenesisextracellular matrixchronic wounds |
| spellingShingle | Gadi Borkow Eyal Melamed The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice Biomedicines copper oxide wound dressings wound healing angiogenesis extracellular matrix chronic wounds |
| title | The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice |
| title_full | The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice |
| title_fullStr | The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice |
| title_full_unstemmed | The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice |
| title_short | The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice |
| title_sort | journey of copper impregnated dressings in wound healing from a medical hypothesis to clinical practice |
| topic | copper oxide wound dressings wound healing angiogenesis extracellular matrix chronic wounds |
| url | https://www.mdpi.com/2227-9059/13/3/562 |
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