Diverse processes in rotavirus vaccine development
Rotavirus is a major cause of severe diarrhea and mortality in children under five years of age, leading to approximately 128,500 deaths annually.1–3 Vaccination is the most effective strategy for preventing rotavirus infection. While two widely used vaccines, Rotarix and RotaTeq, have shown good ef...
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| Format: | Article |
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Taylor & Francis Group
2025-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2025.2475609 |
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| author | Xiaochen Lin Hongjun Li |
| author_facet | Xiaochen Lin Hongjun Li |
| author_sort | Xiaochen Lin |
| collection | DOAJ |
| description | Rotavirus is a major cause of severe diarrhea and mortality in children under five years of age, leading to approximately 128,500 deaths annually.1–3 Vaccination is the most effective strategy for preventing rotavirus infection. While two widely used vaccines, Rotarix and RotaTeq, have shown good efficacy in high-income countries, their effectiveness is lower in low- and middle-income countries due to factors such as malnutrition and poor sanitation.4–6 These challenges include complex vaccination schedules and high production costs. Researchers are working on novel vaccines, including inactivated virus and viral protein-based options, as well as virus-like particles and recombinant proteins.7–9 Improving vaccine stability and applicability is crucial for resource-limited settings, and global vaccination strategies are expected to significantly reduce infection burdens, improve child health, and contribute to the achievement of global health goals.10–14 |
| format | Article |
| id | doaj-art-deec828a2a8149b082a23fd5a2d9a111 |
| institution | DOAJ |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-deec828a2a8149b082a23fd5a2d9a1112025-08-20T02:41:39ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2025-12-0121110.1080/21645515.2025.2475609Diverse processes in rotavirus vaccine developmentXiaochen Lin0Hongjun Li1Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Provincial Key Laboratory of Vaccine R&D for Major Infectious Diseases, Kunming, ChinaInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Provincial Key Laboratory of Vaccine R&D for Major Infectious Diseases, Kunming, ChinaRotavirus is a major cause of severe diarrhea and mortality in children under five years of age, leading to approximately 128,500 deaths annually.1–3 Vaccination is the most effective strategy for preventing rotavirus infection. While two widely used vaccines, Rotarix and RotaTeq, have shown good efficacy in high-income countries, their effectiveness is lower in low- and middle-income countries due to factors such as malnutrition and poor sanitation.4–6 These challenges include complex vaccination schedules and high production costs. Researchers are working on novel vaccines, including inactivated virus and viral protein-based options, as well as virus-like particles and recombinant proteins.7–9 Improving vaccine stability and applicability is crucial for resource-limited settings, and global vaccination strategies are expected to significantly reduce infection burdens, improve child health, and contribute to the achievement of global health goals.10–14https://www.tandfonline.com/doi/10.1080/21645515.2025.2475609Rotavirusrotavirus vaccinetraditional vaccinenon-replicating vaccinemRNA vaccine |
| spellingShingle | Xiaochen Lin Hongjun Li Diverse processes in rotavirus vaccine development Human Vaccines & Immunotherapeutics Rotavirus rotavirus vaccine traditional vaccine non-replicating vaccine mRNA vaccine |
| title | Diverse processes in rotavirus vaccine development |
| title_full | Diverse processes in rotavirus vaccine development |
| title_fullStr | Diverse processes in rotavirus vaccine development |
| title_full_unstemmed | Diverse processes in rotavirus vaccine development |
| title_short | Diverse processes in rotavirus vaccine development |
| title_sort | diverse processes in rotavirus vaccine development |
| topic | Rotavirus rotavirus vaccine traditional vaccine non-replicating vaccine mRNA vaccine |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2025.2475609 |
| work_keys_str_mv | AT xiaochenlin diverseprocessesinrotavirusvaccinedevelopment AT hongjunli diverseprocessesinrotavirusvaccinedevelopment |