Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation
Advanced glycation end products (AGEs) may induce cardiac remodeling in kidney disease by promoting fibroblast growth factor 23 (FGF-23) expression. Since AGEs are increased in diabetes mellitus (DM), our first aim was to evaluate the existence of any potential association between AGEs, FGF-23, infl...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/9845175 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849467403267735552 |
|---|---|
| author | Elena Dozio Valentina Corradi Elena Vianello Elisa Scalzotto Massimo de Cal Massimiliano Marco Corsi Romanelli Claudio Ronco |
| author_facet | Elena Dozio Valentina Corradi Elena Vianello Elisa Scalzotto Massimo de Cal Massimiliano Marco Corsi Romanelli Claudio Ronco |
| author_sort | Elena Dozio |
| collection | DOAJ |
| description | Advanced glycation end products (AGEs) may induce cardiac remodeling in kidney disease by promoting fibroblast growth factor 23 (FGF-23) expression. Since AGEs are increased in diabetes mellitus (DM), our first aim was to evaluate the existence of any potential association between AGEs, FGF-23, inflammation, and increased cardiovascular risk in DM patients on dialysis (CKD-G5D). Secondarily, we explored the potential role of the soluble receptor for AGEs (sRAGE) as a marker of heart failure. Levels of glycated albumin (GA), sRAGE, c-terminal FGF-23 (cFGF-23), brain natriuretic peptide (BNP), and inflammatory mediators were compared between DM and non-DM CKD-G5D patients. The levels of sRAGE, cFGF-23, BNP, and proinflammatory markers were over the ranges of normality in both DM and non-DM groups. Only GA and sRAGE levels were increased in DM compared to non-DM patients. Plasma levels of sRAGE and CRP were the only independent predictors of BNP concentration. In conclusion, in DM CKD-G5D patients, sRAGE appeared to be a marker of cardiac remodeling. Indeed, its increase could be a potential protective mechanism against the increased risk of cardiovascular complications related to AGEs and inflammation. The causal relationship between sRAGE and cardiovascular risk in these patients needs to be further confirmed by mechanistic studies. |
| format | Article |
| id | doaj-art-dee9663c72a246e2a99fb9d6ffa826c0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-dee9663c72a246e2a99fb9d6ffa826c02025-08-20T03:26:15ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/98451759845175Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and InflammationElena Dozio0Valentina Corradi1Elena Vianello2Elisa Scalzotto3Massimo de Cal4Massimiliano Marco Corsi Romanelli5Claudio Ronco6Department of Biomedical Sciences for Health, Università degli Studi di Milano, Via L. Mangiagalli 31, 20133 Milan, ItalyDepartment of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Viale Rodolfi 37, 36100 Vicenza, ItalyDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, Via L. Mangiagalli 31, 20133 Milan, ItalyInternational Renal Research Institute Vicenza (IRRIV), San Bortolo Hospital, Viale Rodolfi 37, 36100 Vicenza, ItalyDepartment of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Viale Rodolfi 37, 36100 Vicenza, ItalyDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, Via L. Mangiagalli 31, 20133 Milan, ItalyDepartment of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Viale Rodolfi 37, 36100 Vicenza, ItalyAdvanced glycation end products (AGEs) may induce cardiac remodeling in kidney disease by promoting fibroblast growth factor 23 (FGF-23) expression. Since AGEs are increased in diabetes mellitus (DM), our first aim was to evaluate the existence of any potential association between AGEs, FGF-23, inflammation, and increased cardiovascular risk in DM patients on dialysis (CKD-G5D). Secondarily, we explored the potential role of the soluble receptor for AGEs (sRAGE) as a marker of heart failure. Levels of glycated albumin (GA), sRAGE, c-terminal FGF-23 (cFGF-23), brain natriuretic peptide (BNP), and inflammatory mediators were compared between DM and non-DM CKD-G5D patients. The levels of sRAGE, cFGF-23, BNP, and proinflammatory markers were over the ranges of normality in both DM and non-DM groups. Only GA and sRAGE levels were increased in DM compared to non-DM patients. Plasma levels of sRAGE and CRP were the only independent predictors of BNP concentration. In conclusion, in DM CKD-G5D patients, sRAGE appeared to be a marker of cardiac remodeling. Indeed, its increase could be a potential protective mechanism against the increased risk of cardiovascular complications related to AGEs and inflammation. The causal relationship between sRAGE and cardiovascular risk in these patients needs to be further confirmed by mechanistic studies.http://dx.doi.org/10.1155/2017/9845175 |
| spellingShingle | Elena Dozio Valentina Corradi Elena Vianello Elisa Scalzotto Massimo de Cal Massimiliano Marco Corsi Romanelli Claudio Ronco Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation Mediators of Inflammation |
| title | Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation |
| title_full | Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation |
| title_fullStr | Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation |
| title_full_unstemmed | Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation |
| title_short | Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation |
| title_sort | increased levels of srage in diabetic ckd g5d patients a potential protective mechanism against age related upregulation of fibroblast growth factor 23 and inflammation |
| url | http://dx.doi.org/10.1155/2017/9845175 |
| work_keys_str_mv | AT elenadozio increasedlevelsofsrageindiabeticckdg5dpatientsapotentialprotectivemechanismagainstagerelatedupregulationoffibroblastgrowthfactor23andinflammation AT valentinacorradi increasedlevelsofsrageindiabeticckdg5dpatientsapotentialprotectivemechanismagainstagerelatedupregulationoffibroblastgrowthfactor23andinflammation AT elenavianello increasedlevelsofsrageindiabeticckdg5dpatientsapotentialprotectivemechanismagainstagerelatedupregulationoffibroblastgrowthfactor23andinflammation AT elisascalzotto increasedlevelsofsrageindiabeticckdg5dpatientsapotentialprotectivemechanismagainstagerelatedupregulationoffibroblastgrowthfactor23andinflammation AT massimodecal increasedlevelsofsrageindiabeticckdg5dpatientsapotentialprotectivemechanismagainstagerelatedupregulationoffibroblastgrowthfactor23andinflammation AT massimilianomarcocorsiromanelli increasedlevelsofsrageindiabeticckdg5dpatientsapotentialprotectivemechanismagainstagerelatedupregulationoffibroblastgrowthfactor23andinflammation AT claudioronco increasedlevelsofsrageindiabeticckdg5dpatientsapotentialprotectivemechanismagainstagerelatedupregulationoffibroblastgrowthfactor23andinflammation |