The Value of TruScreen (An Artificial Intelligence Cervical Cancer Screening System) in High-Risk HPV Positive Patients
Background: To investigate the value of the artificial intelligence cervical cancer screening system TruScreen (TS) in high-risk human papillomavirus (HPV)-positive patients in a clinical setting. Methods: Three hundred and eighteen patients positive for high-risk HPV in the gynecological clinic of...
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IMR Press
2023-10-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/50/10/10.31083/j.ceog5010206 |
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| _version_ | 1849471108964679680 |
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| author | Lianmei Luo Jun Zhang |
| author_facet | Lianmei Luo Jun Zhang |
| author_sort | Lianmei Luo |
| collection | DOAJ |
| description | Background: To investigate the value of the artificial intelligence cervical cancer screening system TruScreen (TS) in high-risk human papillomavirus (HPV)-positive patients in a clinical setting. Methods: Three hundred and eighteen patients positive for high-risk HPV in the gynecological clinic of our hospital from May 2020 to June 2021 were analyzed retrospectively. Colposcopy was performed when it was clinically indicated. Results: Among the 318 patients, 203 were TS negative and 115 were TS positive, of whom 84 were referred for colposcopy and possible biopsy. Among the 318 patents, 74.53% (237/318) had a single type of HPV infection, and 25.47% (81/318) had more than two types of HPV infection. In terms of HPV types, the top 5 types were 52, 58, 51, 56 and 16. HPV52 accounted for 27.4% (87/318), followed by HPV58, accounting for 17.30% (55/318). A total of 84 patients underwent colposcopy. The negative predictive values of TS and thinprep cytology test (TCT) screening for cervical cancer and precancerous lesions were 33.33% and 16.90%, respectively. The positive predictive values were 88.41% and 92.31%, respectively. The sensitivity was 85.92% and 16.90%, respectively. The specificity was 38.46% and 92.31%, respectively. Among 251 non-16/18 high-risk HPV-positive patients with TCT negative intraepithelial lesion or malignancy (NILM) 49 underwent colposcopy. The positive predictive value of TS for cervical cancer and precancerous lesions was 84.78% and the sensitivity was 92.86%. Conclusions: This study demonstrated that in a clinical setting, TS had a better sensitivity than TCT in cervical cancer screening, but less specificity than TCT. In the non-16/18 HPV-positive population with TCT NILM, TS screening can be considered as having potential for clinical management. However, the current research sample size was small, and further research needs to be performed with a larger sample size. |
| format | Article |
| id | doaj-art-dee73bee2b3647e6ad542855c3ce1181 |
| institution | Kabale University |
| issn | 0390-6663 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-dee73bee2b3647e6ad542855c3ce11812025-08-20T03:24:56ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632023-10-01501020610.31083/j.ceog5010206S0390-6663(23)02142-5The Value of TruScreen (An Artificial Intelligence Cervical Cancer Screening System) in High-Risk HPV Positive PatientsLianmei Luo0Jun Zhang1Department of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, ChinaDepartment of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, ChinaBackground: To investigate the value of the artificial intelligence cervical cancer screening system TruScreen (TS) in high-risk human papillomavirus (HPV)-positive patients in a clinical setting. Methods: Three hundred and eighteen patients positive for high-risk HPV in the gynecological clinic of our hospital from May 2020 to June 2021 were analyzed retrospectively. Colposcopy was performed when it was clinically indicated. Results: Among the 318 patients, 203 were TS negative and 115 were TS positive, of whom 84 were referred for colposcopy and possible biopsy. Among the 318 patents, 74.53% (237/318) had a single type of HPV infection, and 25.47% (81/318) had more than two types of HPV infection. In terms of HPV types, the top 5 types were 52, 58, 51, 56 and 16. HPV52 accounted for 27.4% (87/318), followed by HPV58, accounting for 17.30% (55/318). A total of 84 patients underwent colposcopy. The negative predictive values of TS and thinprep cytology test (TCT) screening for cervical cancer and precancerous lesions were 33.33% and 16.90%, respectively. The positive predictive values were 88.41% and 92.31%, respectively. The sensitivity was 85.92% and 16.90%, respectively. The specificity was 38.46% and 92.31%, respectively. Among 251 non-16/18 high-risk HPV-positive patients with TCT negative intraepithelial lesion or malignancy (NILM) 49 underwent colposcopy. The positive predictive value of TS for cervical cancer and precancerous lesions was 84.78% and the sensitivity was 92.86%. Conclusions: This study demonstrated that in a clinical setting, TS had a better sensitivity than TCT in cervical cancer screening, but less specificity than TCT. In the non-16/18 HPV-positive population with TCT NILM, TS screening can be considered as having potential for clinical management. However, the current research sample size was small, and further research needs to be performed with a larger sample size.https://www.imrpress.com/journal/CEOG/50/10/10.31083/j.ceog5010206cervical cancer screeninghpvtruscreenliquid based cytologytriage |
| spellingShingle | Lianmei Luo Jun Zhang The Value of TruScreen (An Artificial Intelligence Cervical Cancer Screening System) in High-Risk HPV Positive Patients Clinical and Experimental Obstetrics & Gynecology cervical cancer screening hpv truscreen liquid based cytology triage |
| title | The Value of TruScreen (An Artificial Intelligence Cervical Cancer Screening System) in High-Risk HPV Positive Patients |
| title_full | The Value of TruScreen (An Artificial Intelligence Cervical Cancer Screening System) in High-Risk HPV Positive Patients |
| title_fullStr | The Value of TruScreen (An Artificial Intelligence Cervical Cancer Screening System) in High-Risk HPV Positive Patients |
| title_full_unstemmed | The Value of TruScreen (An Artificial Intelligence Cervical Cancer Screening System) in High-Risk HPV Positive Patients |
| title_short | The Value of TruScreen (An Artificial Intelligence Cervical Cancer Screening System) in High-Risk HPV Positive Patients |
| title_sort | value of truscreen an artificial intelligence cervical cancer screening system in high risk hpv positive patients |
| topic | cervical cancer screening hpv truscreen liquid based cytology triage |
| url | https://www.imrpress.com/journal/CEOG/50/10/10.31083/j.ceog5010206 |
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