Comparison of Changes in Cortisol Values Before and After Administration of a Combination of Continuous Fentanyl and Paracetamol Drip in Post-Craniotomy Patients in ICU of Haji Adam Malik General Hospital Medan
Introduction: Post-craniotomy surgical pain can trigger an inflammatory response and release various stress response mediators. Prolonged stress response to pain can increase cortisol secretion which will eventually be resulted in cortisol dysfunction and widespread inflammation. Opioids have been s...
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| Format: | Article |
| Language: | Indonesian |
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Indonesian Society of Neuroanesthesia & Critical Care (INA-SNACC)
2025-10-01
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| Series: | Jurnal Neuroanestesi Indonesia |
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| Online Access: | https://inasnacc.org/ojs2/index.php/jni/article/view/593 |
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| author | Cassandra Etania Rr Sinta Irina Muhammad Ihsan |
| author_facet | Cassandra Etania Rr Sinta Irina Muhammad Ihsan |
| author_sort | Cassandra Etania |
| collection | DOAJ |
| description | Introduction: Post-craniotomy surgical pain can trigger an inflammatory response and release various stress response mediators. Prolonged stress response to pain can increase cortisol secretion which will eventually be resulted in cortisol dysfunction and widespread inflammation. Opioids have been shown to provide pain management after craniotomy. Fentanyl is a commonly used opioid analgesic to manage postoperative pain. The addition of paracetamol is often used as multimodal analgesia which aims to reduce postoperative pain and to minimize the stress response that occurs. The aim of the study was to obtain a comparison of changes in cortisol values before and after the administration of a combination of continuous fentanyl and paracetamol in post-craniotomy patients in the ICU of Haji Adam Malik General Hospital Medan.
Subject and Methods: This research design used a cross sectional test with pretest and posttest design, with primary data sources obtained directly from examinations on patients in the ICU. This study involved 15 post-craniotomy patients in the ICU with mechanical ventilation. The cortisol levels in the patient’s blood were checked before and after administration continuous fentanyl and paracetamol drip.
Results: There was a decrease in cortisol levels after being given a combination of continuous fentanyl and paracetamol drip in post-craniotomy patients by 18% with a p-value of 0.001 (p <0.05).
Conclusion: Combination of continuous fentanyl and paracetamol drip can provide analgesia effects that can reduce the stress response, namely cortisol. |
| format | Article |
| id | doaj-art-dee6f62fa699476e89a4356ef8d387be |
| institution | OA Journals |
| issn | 2088-9674 2460-2302 |
| language | Indonesian |
| publishDate | 2025-10-01 |
| publisher | Indonesian Society of Neuroanesthesia & Critical Care (INA-SNACC) |
| record_format | Article |
| series | Jurnal Neuroanestesi Indonesia |
| spelling | doaj-art-dee6f62fa699476e89a4356ef8d387be2025-08-20T01:47:37ZindIndonesian Society of Neuroanesthesia & Critical Care (INA-SNACC)Jurnal Neuroanestesi Indonesia2088-96742460-23022025-10-01133115121https://doi.org/10.24244/jni.v13i3.593Comparison of Changes in Cortisol Values Before and After Administration of a Combination of Continuous Fentanyl and Paracetamol Drip in Post-Craniotomy Patients in ICU of Haji Adam Malik General Hospital MedanCassandra Etania0Rr Sinta Irina1 Muhammad Ihsan2Resident of Clinical Medicine Study Program, Department of Anesthesiology and Intensive Therapy of Universitas Sumatera Utara, MedanDepartment of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Sumatra Utara, MedanDepartment of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Sumatra Utara, MedanIntroduction: Post-craniotomy surgical pain can trigger an inflammatory response and release various stress response mediators. Prolonged stress response to pain can increase cortisol secretion which will eventually be resulted in cortisol dysfunction and widespread inflammation. Opioids have been shown to provide pain management after craniotomy. Fentanyl is a commonly used opioid analgesic to manage postoperative pain. The addition of paracetamol is often used as multimodal analgesia which aims to reduce postoperative pain and to minimize the stress response that occurs. The aim of the study was to obtain a comparison of changes in cortisol values before and after the administration of a combination of continuous fentanyl and paracetamol in post-craniotomy patients in the ICU of Haji Adam Malik General Hospital Medan. Subject and Methods: This research design used a cross sectional test with pretest and posttest design, with primary data sources obtained directly from examinations on patients in the ICU. This study involved 15 post-craniotomy patients in the ICU with mechanical ventilation. The cortisol levels in the patient’s blood were checked before and after administration continuous fentanyl and paracetamol drip. Results: There was a decrease in cortisol levels after being given a combination of continuous fentanyl and paracetamol drip in post-craniotomy patients by 18% with a p-value of 0.001 (p <0.05). Conclusion: Combination of continuous fentanyl and paracetamol drip can provide analgesia effects that can reduce the stress response, namely cortisol.https://inasnacc.org/ojs2/index.php/jni/article/view/593craniotomyicufentanylparacetamolcortisol |
| spellingShingle | Cassandra Etania Rr Sinta Irina Muhammad Ihsan Comparison of Changes in Cortisol Values Before and After Administration of a Combination of Continuous Fentanyl and Paracetamol Drip in Post-Craniotomy Patients in ICU of Haji Adam Malik General Hospital Medan Jurnal Neuroanestesi Indonesia craniotomy icu fentanyl paracetamol cortisol |
| title | Comparison of Changes in Cortisol Values Before and After Administration of a Combination of Continuous Fentanyl and Paracetamol Drip in Post-Craniotomy Patients in ICU of Haji Adam Malik General Hospital Medan |
| title_full | Comparison of Changes in Cortisol Values Before and After Administration of a Combination of Continuous Fentanyl and Paracetamol Drip in Post-Craniotomy Patients in ICU of Haji Adam Malik General Hospital Medan |
| title_fullStr | Comparison of Changes in Cortisol Values Before and After Administration of a Combination of Continuous Fentanyl and Paracetamol Drip in Post-Craniotomy Patients in ICU of Haji Adam Malik General Hospital Medan |
| title_full_unstemmed | Comparison of Changes in Cortisol Values Before and After Administration of a Combination of Continuous Fentanyl and Paracetamol Drip in Post-Craniotomy Patients in ICU of Haji Adam Malik General Hospital Medan |
| title_short | Comparison of Changes in Cortisol Values Before and After Administration of a Combination of Continuous Fentanyl and Paracetamol Drip in Post-Craniotomy Patients in ICU of Haji Adam Malik General Hospital Medan |
| title_sort | comparison of changes in cortisol values before and after administration of a combination of continuous fentanyl and paracetamol drip in post craniotomy patients in icu of haji adam malik general hospital medan |
| topic | craniotomy icu fentanyl paracetamol cortisol |
| url | https://inasnacc.org/ojs2/index.php/jni/article/view/593 |
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