Exploring the forensic effectiveness and population genetic differentiation in Guizhou Miao and Bouyei group by the self-constructed panel of X chromosomal multi-insertion/deletions
Abstract In this research, a self-developed panel comprising 22 X chromosomal multi-InDels and one X-STR was used to explore the genetic polymorphisms and forensic characteristics of these loci in Guizhou Miao and Guizhou Bouyei populations. Besides, genetic affiliations among Guizhou Miao, Guizhou...
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| Language: | English |
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BMC
2024-12-01
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| Series: | BMC Genomics |
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| Online Access: | https://doi.org/10.1186/s12864-024-11088-2 |
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| author | Xiaolan Huang Changyun Gu Qianchong Ran Li Chen Shunyi Tian Min Zhong Zheng Ren Qiyan Wang Meiqing Yang Jingyan Ji Wen Wan Jiang Huang Hongling Zhang Xiaoye Jin |
| author_facet | Xiaolan Huang Changyun Gu Qianchong Ran Li Chen Shunyi Tian Min Zhong Zheng Ren Qiyan Wang Meiqing Yang Jingyan Ji Wen Wan Jiang Huang Hongling Zhang Xiaoye Jin |
| author_sort | Xiaolan Huang |
| collection | DOAJ |
| description | Abstract In this research, a self-developed panel comprising 22 X chromosomal multi-InDels and one X-STR was used to explore the genetic polymorphisms and forensic characteristics of these loci in Guizhou Miao and Guizhou Bouyei populations. Besides, genetic affiliations among Guizhou Miao, Guizhou Bouyei and Guizhou Han populations were investigated using principal component analysis, STRUCTURE and machine learning methods. The findings indicated that these loci in the male and female samples had comprehensive discrimination powers greater than 0.999999999. Meanwhile, the cumulative mean exclusion chance of these 23 loci for trio and duo cases were also greater than 0.9999 in Guizhou Miao and Guizhou Bouyei populations. Population genetic analyses of three Guizhou populations revealed that there were relatively low genetic divergences among these populations based on the self-constructed panel. In conclusion, this system could be utilized as the valuable tool for forensic personal identification and parentage testing in Guizhou Miao and Guizhou Bouyei populations. |
| format | Article |
| id | doaj-art-dee3f7f42867478f8a35964a0bc85f21 |
| institution | OA Journals |
| issn | 1471-2164 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj-art-dee3f7f42867478f8a35964a0bc85f212025-08-20T01:56:24ZengBMCBMC Genomics1471-21642024-12-012511810.1186/s12864-024-11088-2Exploring the forensic effectiveness and population genetic differentiation in Guizhou Miao and Bouyei group by the self-constructed panel of X chromosomal multi-insertion/deletionsXiaolan Huang0Changyun Gu1Qianchong Ran2Li Chen3Shunyi Tian4Min Zhong5Zheng Ren6Qiyan Wang7Meiqing Yang8Jingyan Ji9Wen Wan10Jiang Huang11Hongling Zhang12Xiaoye Jin13Department of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversitySchool of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityDepartment of Forensic Medicine, Guizhou Medical UniversityAbstract In this research, a self-developed panel comprising 22 X chromosomal multi-InDels and one X-STR was used to explore the genetic polymorphisms and forensic characteristics of these loci in Guizhou Miao and Guizhou Bouyei populations. Besides, genetic affiliations among Guizhou Miao, Guizhou Bouyei and Guizhou Han populations were investigated using principal component analysis, STRUCTURE and machine learning methods. The findings indicated that these loci in the male and female samples had comprehensive discrimination powers greater than 0.999999999. Meanwhile, the cumulative mean exclusion chance of these 23 loci for trio and duo cases were also greater than 0.9999 in Guizhou Miao and Guizhou Bouyei populations. Population genetic analyses of three Guizhou populations revealed that there were relatively low genetic divergences among these populations based on the self-constructed panel. In conclusion, this system could be utilized as the valuable tool for forensic personal identification and parentage testing in Guizhou Miao and Guizhou Bouyei populations.https://doi.org/10.1186/s12864-024-11088-2X chromosomeMulti-InDelGuizhou MiaoGuizhou BouyeiForensics |
| spellingShingle | Xiaolan Huang Changyun Gu Qianchong Ran Li Chen Shunyi Tian Min Zhong Zheng Ren Qiyan Wang Meiqing Yang Jingyan Ji Wen Wan Jiang Huang Hongling Zhang Xiaoye Jin Exploring the forensic effectiveness and population genetic differentiation in Guizhou Miao and Bouyei group by the self-constructed panel of X chromosomal multi-insertion/deletions BMC Genomics X chromosome Multi-InDel Guizhou Miao Guizhou Bouyei Forensics |
| title | Exploring the forensic effectiveness and population genetic differentiation in Guizhou Miao and Bouyei group by the self-constructed panel of X chromosomal multi-insertion/deletions |
| title_full | Exploring the forensic effectiveness and population genetic differentiation in Guizhou Miao and Bouyei group by the self-constructed panel of X chromosomal multi-insertion/deletions |
| title_fullStr | Exploring the forensic effectiveness and population genetic differentiation in Guizhou Miao and Bouyei group by the self-constructed panel of X chromosomal multi-insertion/deletions |
| title_full_unstemmed | Exploring the forensic effectiveness and population genetic differentiation in Guizhou Miao and Bouyei group by the self-constructed panel of X chromosomal multi-insertion/deletions |
| title_short | Exploring the forensic effectiveness and population genetic differentiation in Guizhou Miao and Bouyei group by the self-constructed panel of X chromosomal multi-insertion/deletions |
| title_sort | exploring the forensic effectiveness and population genetic differentiation in guizhou miao and bouyei group by the self constructed panel of x chromosomal multi insertion deletions |
| topic | X chromosome Multi-InDel Guizhou Miao Guizhou Bouyei Forensics |
| url | https://doi.org/10.1186/s12864-024-11088-2 |
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