Molecular mechanisms and therapeutic advances of peritubular capillary neogenesis in acute kidney injury
Acute kidney injury is a clinical syndrome characterized by a rapid decline in renal function, driven by pathological mechanisms such as renal tubular epithelial cell injury, inflammatory responses, and microcirculatory dysfunction. In recent years, the role of angiogenesis in AKI recovery and regen...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-08-01
|
| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1643838/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849233702714867712 |
|---|---|
| author | Yuming Ding Yuming Ding Yuming Ding Linmei Gao Linmei Gao Linmei Gao Yi Chen Yi Chen Yi Chen Yanheng Qiao Yanheng Qiao Bo Yang Bo Yang |
| author_facet | Yuming Ding Yuming Ding Yuming Ding Linmei Gao Linmei Gao Linmei Gao Yi Chen Yi Chen Yi Chen Yanheng Qiao Yanheng Qiao Bo Yang Bo Yang |
| author_sort | Yuming Ding |
| collection | DOAJ |
| description | Acute kidney injury is a clinical syndrome characterized by a rapid decline in renal function, driven by pathological mechanisms such as renal tubular epithelial cell injury, inflammatory responses, and microcirculatory dysfunction. In recent years, the role of angiogenesis in AKI recovery and regeneration has gained increasing attention. Angiogenesis plays a dual role in tissue repair and pathological remodeling, exhibiting complex spatiotemporal dynamics during AKI progression. This review synthesizes recent advances in understanding the role of angiogenesis in AKI, with the aim of identifying potential diagnostic and therapeutic strategies. Studies indicate that the ischemic-hypoxic microenvironment following AKI activates key signaling pathways, including hypoxia-inducible factor-1α, which subsequently upregulates vascular endothelial growth factor and angiopoietins, thereby modulating intrarenal angiogenesis. Controlled angiogenesis may enhance regional perfusion, mitigate hypoxic injury, and facilitate tubular repair, whereas excessive or dysregulated angiogenesis can contribute to maladaptive vascular remodeling and fibrotic progression. Current research efforts focus on therapeutic strategies aimed at modulating angiogenesis, such as exogenous VEGF administration, endothelial progenitor cell transplantation, and Notch signaling modulation, to promote functional vascular regeneration. However, the precise role of angiogenesis varies across different AKI phases (acute vs recovery), and its interactions with inflammatory and fibrotic pathways remain incompletely understood. Further elucidation of these mechanisms is essential for developing targeted therapeutic interventions. |
| format | Article |
| id | doaj-art-dee040d2f20148d99d1772bb77d7fb10 |
| institution | Kabale University |
| issn | 2296-889X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj-art-dee040d2f20148d99d1772bb77d7fb102025-08-20T04:14:09ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2025-08-011210.3389/fmolb.2025.16438381643838Molecular mechanisms and therapeutic advances of peritubular capillary neogenesis in acute kidney injuryYuming Ding0Yuming Ding1Yuming Ding2Linmei Gao3Linmei Gao4Linmei Gao5Yi Chen6Yi Chen7Yi Chen8Yanheng Qiao9Yanheng Qiao10Bo Yang11Bo Yang12Department of Nephrology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaTianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Nephrology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaTianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Nephrology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaTianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Nephrology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaDepartment of Nephrology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaAcute kidney injury is a clinical syndrome characterized by a rapid decline in renal function, driven by pathological mechanisms such as renal tubular epithelial cell injury, inflammatory responses, and microcirculatory dysfunction. In recent years, the role of angiogenesis in AKI recovery and regeneration has gained increasing attention. Angiogenesis plays a dual role in tissue repair and pathological remodeling, exhibiting complex spatiotemporal dynamics during AKI progression. This review synthesizes recent advances in understanding the role of angiogenesis in AKI, with the aim of identifying potential diagnostic and therapeutic strategies. Studies indicate that the ischemic-hypoxic microenvironment following AKI activates key signaling pathways, including hypoxia-inducible factor-1α, which subsequently upregulates vascular endothelial growth factor and angiopoietins, thereby modulating intrarenal angiogenesis. Controlled angiogenesis may enhance regional perfusion, mitigate hypoxic injury, and facilitate tubular repair, whereas excessive or dysregulated angiogenesis can contribute to maladaptive vascular remodeling and fibrotic progression. Current research efforts focus on therapeutic strategies aimed at modulating angiogenesis, such as exogenous VEGF administration, endothelial progenitor cell transplantation, and Notch signaling modulation, to promote functional vascular regeneration. However, the precise role of angiogenesis varies across different AKI phases (acute vs recovery), and its interactions with inflammatory and fibrotic pathways remain incompletely understood. Further elucidation of these mechanisms is essential for developing targeted therapeutic interventions.https://www.frontiersin.org/articles/10.3389/fmolb.2025.1643838/fullacute kidney injuryperitubular capillariesangiogenesisendothelial cellpericyte |
| spellingShingle | Yuming Ding Yuming Ding Yuming Ding Linmei Gao Linmei Gao Linmei Gao Yi Chen Yi Chen Yi Chen Yanheng Qiao Yanheng Qiao Bo Yang Bo Yang Molecular mechanisms and therapeutic advances of peritubular capillary neogenesis in acute kidney injury Frontiers in Molecular Biosciences acute kidney injury peritubular capillaries angiogenesis endothelial cell pericyte |
| title | Molecular mechanisms and therapeutic advances of peritubular capillary neogenesis in acute kidney injury |
| title_full | Molecular mechanisms and therapeutic advances of peritubular capillary neogenesis in acute kidney injury |
| title_fullStr | Molecular mechanisms and therapeutic advances of peritubular capillary neogenesis in acute kidney injury |
| title_full_unstemmed | Molecular mechanisms and therapeutic advances of peritubular capillary neogenesis in acute kidney injury |
| title_short | Molecular mechanisms and therapeutic advances of peritubular capillary neogenesis in acute kidney injury |
| title_sort | molecular mechanisms and therapeutic advances of peritubular capillary neogenesis in acute kidney injury |
| topic | acute kidney injury peritubular capillaries angiogenesis endothelial cell pericyte |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1643838/full |
| work_keys_str_mv | AT yumingding molecularmechanismsandtherapeuticadvancesofperitubularcapillaryneogenesisinacutekidneyinjury AT yumingding molecularmechanismsandtherapeuticadvancesofperitubularcapillaryneogenesisinacutekidneyinjury AT yumingding molecularmechanismsandtherapeuticadvancesofperitubularcapillaryneogenesisinacutekidneyinjury AT linmeigao molecularmechanismsandtherapeuticadvancesofperitubularcapillaryneogenesisinacutekidneyinjury AT linmeigao molecularmechanismsandtherapeuticadvancesofperitubularcapillaryneogenesisinacutekidneyinjury AT linmeigao molecularmechanismsandtherapeuticadvancesofperitubularcapillaryneogenesisinacutekidneyinjury AT yichen molecularmechanismsandtherapeuticadvancesofperitubularcapillaryneogenesisinacutekidneyinjury AT yichen molecularmechanismsandtherapeuticadvancesofperitubularcapillaryneogenesisinacutekidneyinjury AT yichen molecularmechanismsandtherapeuticadvancesofperitubularcapillaryneogenesisinacutekidneyinjury AT yanhengqiao molecularmechanismsandtherapeuticadvancesofperitubularcapillaryneogenesisinacutekidneyinjury AT yanhengqiao molecularmechanismsandtherapeuticadvancesofperitubularcapillaryneogenesisinacutekidneyinjury AT boyang molecularmechanismsandtherapeuticadvancesofperitubularcapillaryneogenesisinacutekidneyinjury AT boyang molecularmechanismsandtherapeuticadvancesofperitubularcapillaryneogenesisinacutekidneyinjury |