An Efficient, Three-Component Synthesis of 3,4-Di Hydropyrimidin-2(1H)-Ones Using LaCl3/ClCH2COOH as Environmentally Benign and Green Catalytic System
An improved, simple, and facile synthesis of 3,4-dihydropyrimidin-2(1H)-ones by employing three-component, one-pot condensation reaction of β-keto ester, aromatic aldehydes, and urea or N-methylurea using LaCl3/ClCH2COOH as an inexpensive and green chemistry catalyst system under solvent-free condit...
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| Format: | Article |
| Language: | English |
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University of Tehran
2014-12-01
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| Series: | Journal of Sciences, Islamic Republic of Iran |
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| Online Access: | https://jsciences.ut.ac.ir/article_52616_116a5cdd476c52f0ecbf55f77067c06c.pdf |
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| author | B. Pouramiri E. Tavakolinejad Kermany H. Khajesamani H. Khabazzadeh |
| author_facet | B. Pouramiri E. Tavakolinejad Kermany H. Khajesamani H. Khabazzadeh |
| author_sort | B. Pouramiri |
| collection | DOAJ |
| description | An improved, simple, and facile synthesis of 3,4-dihydropyrimidin-2(1H)-ones by employing three-component, one-pot condensation reaction of β-keto ester, aromatic aldehydes, and urea or N-methylurea using LaCl3/ClCH2COOH as an inexpensive and green chemistry catalyst system under solvent-free conditions described. Compared with the classicalBiginelli reaction conditions, this method has the advantages of good to excellent yields (80-99%) and short reaction time. |
| format | Article |
| id | doaj-art-dedd06a6f44a48909cf41ac6d0ea13b1 |
| institution | DOAJ |
| issn | 1016-1104 2345-6914 |
| language | English |
| publishDate | 2014-12-01 |
| publisher | University of Tehran |
| record_format | Article |
| series | Journal of Sciences, Islamic Republic of Iran |
| spelling | doaj-art-dedd06a6f44a48909cf41ac6d0ea13b12025-08-20T03:13:36ZengUniversity of TehranJournal of Sciences, Islamic Republic of Iran1016-11042345-69142014-12-0125432332752616An Efficient, Three-Component Synthesis of 3,4-Di Hydropyrimidin-2(1H)-Ones Using LaCl3/ClCH2COOH as Environmentally Benign and Green Catalytic SystemB. Pouramiri0E. Tavakolinejad Kermany1H. Khajesamani2H. Khabazzadeh3Department of Chemistry,Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman 76169, Islamic Republic of IranDepartment of Chemistry,Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman 76169, Islamic Republic of IranDepartment of Chemistry,Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman 76169, Islamic Republic of IranDepartment of Chemistry,Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman 76169, Islamic Republic of IranAn improved, simple, and facile synthesis of 3,4-dihydropyrimidin-2(1H)-ones by employing three-component, one-pot condensation reaction of β-keto ester, aromatic aldehydes, and urea or N-methylurea using LaCl3/ClCH2COOH as an inexpensive and green chemistry catalyst system under solvent-free conditions described. Compared with the classicalBiginelli reaction conditions, this method has the advantages of good to excellent yields (80-99%) and short reaction time.https://jsciences.ut.ac.ir/article_52616_116a5cdd476c52f0ecbf55f77067c06c.pdfdihydropyrimidinoneslanthanum(iii)chloridesolvent –freeone-pot condensation |
| spellingShingle | B. Pouramiri E. Tavakolinejad Kermany H. Khajesamani H. Khabazzadeh An Efficient, Three-Component Synthesis of 3,4-Di Hydropyrimidin-2(1H)-Ones Using LaCl3/ClCH2COOH as Environmentally Benign and Green Catalytic System Journal of Sciences, Islamic Republic of Iran dihydropyrimidinones lanthanum(iii)chloride solvent –free one-pot condensation |
| title | An Efficient, Three-Component Synthesis of 3,4-Di Hydropyrimidin-2(1H)-Ones Using LaCl3/ClCH2COOH as Environmentally Benign and Green Catalytic System |
| title_full | An Efficient, Three-Component Synthesis of 3,4-Di Hydropyrimidin-2(1H)-Ones Using LaCl3/ClCH2COOH as Environmentally Benign and Green Catalytic System |
| title_fullStr | An Efficient, Three-Component Synthesis of 3,4-Di Hydropyrimidin-2(1H)-Ones Using LaCl3/ClCH2COOH as Environmentally Benign and Green Catalytic System |
| title_full_unstemmed | An Efficient, Three-Component Synthesis of 3,4-Di Hydropyrimidin-2(1H)-Ones Using LaCl3/ClCH2COOH as Environmentally Benign and Green Catalytic System |
| title_short | An Efficient, Three-Component Synthesis of 3,4-Di Hydropyrimidin-2(1H)-Ones Using LaCl3/ClCH2COOH as Environmentally Benign and Green Catalytic System |
| title_sort | efficient three component synthesis of 3 4 di hydropyrimidin 2 1h ones using lacl3 clch2cooh as environmentally benign and green catalytic system |
| topic | dihydropyrimidinones lanthanum(iii)chloride solvent –free one-pot condensation |
| url | https://jsciences.ut.ac.ir/article_52616_116a5cdd476c52f0ecbf55f77067c06c.pdf |
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