Efficacy and safety outcomes of the Paul glaucoma implant compared to the Ahmed glaucoma valve
Abstract This study compares the one-year outcomes of standalone Ahmed glaucoma valve (AGV) implantation and standalone Paul glaucoma implant (PGI) in adult patients with primary and secondary glaucoma. A retrospective, single-center, comparative study was conducted on adult patients who underwent s...
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Nature Portfolio
2025-05-01
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| Online Access: | https://doi.org/10.1038/s41598-025-00839-0 |
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| author | Angi Lizbeth Mendoza-Moreira Julia V. Stingl Anna Maria Voigt Jasmin Rezapour Achim Fiess Felix Mathias Wagner Alexander K. Schuster Esther M. Hoffmann |
| author_facet | Angi Lizbeth Mendoza-Moreira Julia V. Stingl Anna Maria Voigt Jasmin Rezapour Achim Fiess Felix Mathias Wagner Alexander K. Schuster Esther M. Hoffmann |
| author_sort | Angi Lizbeth Mendoza-Moreira |
| collection | DOAJ |
| description | Abstract This study compares the one-year outcomes of standalone Ahmed glaucoma valve (AGV) implantation and standalone Paul glaucoma implant (PGI) in adult patients with primary and secondary glaucoma. A retrospective, single-center, comparative study was conducted on adult patients who underwent standalone PGI and AGV at the University Medical Center Mainz. The primary outcome measures were the changes of IOP and the number of antiglaucoma eye medication at one year postoperatively. Secondary outcome measures included complete and qualified success rates, failure rates, visual acuity logMAR and the incidence of adverse events. A total of 24 adult patients were included in the AGV group and 28 in the PGI group. The median preoperative intraocular pressure decreased from 29.5mmHg (Interquartile range (IQR) 21–42) to 16.0mmHg (IQR 7–37) in the AGV group, and from 34.0 mmHg (IQR 13–56) to 16.0 (IQR 7–21) mmHg in the PGI group at the one-year follow-up. The median number of classes of intraocular pressure-lowering medications reduced from 3.5 to 0 in the AGV group, and from 3.0 to 0 in the PGI group. There were no statistically significant differences between the groups for any success criteria or failure. The AGV produced more encapsulation than the PGI, and the latter more tube exposures. Both the Ahmed Glaucoma Valve and the Paul Glaucoma Implant effectively reduce IOP and the number of antiglaucoma medications at one year with comparable safety profiles. |
| format | Article |
| id | doaj-art-dedaa8ca76734a56bdde0ff871e8ac51 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-dedaa8ca76734a56bdde0ff871e8ac512025-08-20T03:10:17ZengNature PortfolioScientific Reports2045-23222025-05-0115111510.1038/s41598-025-00839-0Efficacy and safety outcomes of the Paul glaucoma implant compared to the Ahmed glaucoma valveAngi Lizbeth Mendoza-Moreira0Julia V. Stingl1Anna Maria Voigt2Jasmin Rezapour3Achim Fiess4Felix Mathias Wagner5Alexander K. Schuster6Esther M. Hoffmann7Department of Ophthalmology, University Medical Center MainzDepartment of Ophthalmology, University Medical Center MainzDepartment of Ophthalmology, University Medical Center MainzDepartment of Ophthalmology, University Medical Center MainzDepartment of Ophthalmology, University Medical Center MainzDepartment of Ophthalmology, University Medical Center MainzDepartment of Ophthalmology, University Medical Center MainzDepartment of Ophthalmology, University Medical Center MainzAbstract This study compares the one-year outcomes of standalone Ahmed glaucoma valve (AGV) implantation and standalone Paul glaucoma implant (PGI) in adult patients with primary and secondary glaucoma. A retrospective, single-center, comparative study was conducted on adult patients who underwent standalone PGI and AGV at the University Medical Center Mainz. The primary outcome measures were the changes of IOP and the number of antiglaucoma eye medication at one year postoperatively. Secondary outcome measures included complete and qualified success rates, failure rates, visual acuity logMAR and the incidence of adverse events. A total of 24 adult patients were included in the AGV group and 28 in the PGI group. The median preoperative intraocular pressure decreased from 29.5mmHg (Interquartile range (IQR) 21–42) to 16.0mmHg (IQR 7–37) in the AGV group, and from 34.0 mmHg (IQR 13–56) to 16.0 (IQR 7–21) mmHg in the PGI group at the one-year follow-up. The median number of classes of intraocular pressure-lowering medications reduced from 3.5 to 0 in the AGV group, and from 3.0 to 0 in the PGI group. There were no statistically significant differences between the groups for any success criteria or failure. The AGV produced more encapsulation than the PGI, and the latter more tube exposures. Both the Ahmed Glaucoma Valve and the Paul Glaucoma Implant effectively reduce IOP and the number of antiglaucoma medications at one year with comparable safety profiles.https://doi.org/10.1038/s41598-025-00839-0Ahmed glaucoma valveDrainagePaul glaucoma implantGlaucomaTube |
| spellingShingle | Angi Lizbeth Mendoza-Moreira Julia V. Stingl Anna Maria Voigt Jasmin Rezapour Achim Fiess Felix Mathias Wagner Alexander K. Schuster Esther M. Hoffmann Efficacy and safety outcomes of the Paul glaucoma implant compared to the Ahmed glaucoma valve Scientific Reports Ahmed glaucoma valve Drainage Paul glaucoma implant Glaucoma Tube |
| title | Efficacy and safety outcomes of the Paul glaucoma implant compared to the Ahmed glaucoma valve |
| title_full | Efficacy and safety outcomes of the Paul glaucoma implant compared to the Ahmed glaucoma valve |
| title_fullStr | Efficacy and safety outcomes of the Paul glaucoma implant compared to the Ahmed glaucoma valve |
| title_full_unstemmed | Efficacy and safety outcomes of the Paul glaucoma implant compared to the Ahmed glaucoma valve |
| title_short | Efficacy and safety outcomes of the Paul glaucoma implant compared to the Ahmed glaucoma valve |
| title_sort | efficacy and safety outcomes of the paul glaucoma implant compared to the ahmed glaucoma valve |
| topic | Ahmed glaucoma valve Drainage Paul glaucoma implant Glaucoma Tube |
| url | https://doi.org/10.1038/s41598-025-00839-0 |
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