A biodegradable and restorative peripheral neural interface for the interrogation of neuropathic injuries
Abstract Monitoring the early-stage healing of severe traumatic nerve injuries is essential to gather physiological and pathological information for timely interventions and optimal clinical outcomes. Traditional diagnostic methods relying on physical examinations, imaging tools, and intraoperative...
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Nature Portfolio
2025-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56089-1 |
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| author | Liu Wang Tieyuan Zhang Jiaxin Lei Shirong Wang Yanjun Guan Kuntao Chen Chaochao Li Yahao Song Weining Li Shimeng Wang Zhibo Jia Shengfeng Chen Jun Bai Bingbing Yu Can Yang Pengcheng Sun Qingyun Wang Xing Sheng Jiang Peng Yubo Fan Lizhen Wang Milin Zhang Yu Wang Lan Yin |
| author_facet | Liu Wang Tieyuan Zhang Jiaxin Lei Shirong Wang Yanjun Guan Kuntao Chen Chaochao Li Yahao Song Weining Li Shimeng Wang Zhibo Jia Shengfeng Chen Jun Bai Bingbing Yu Can Yang Pengcheng Sun Qingyun Wang Xing Sheng Jiang Peng Yubo Fan Lizhen Wang Milin Zhang Yu Wang Lan Yin |
| author_sort | Liu Wang |
| collection | DOAJ |
| description | Abstract Monitoring the early-stage healing of severe traumatic nerve injuries is essential to gather physiological and pathological information for timely interventions and optimal clinical outcomes. Traditional diagnostic methods relying on physical examinations, imaging tools, and intraoperative electrophysiological testing present great challenges in continuous and remote monitoring. While implantable peripheral nerve interfaces provide direct access to nerve fibers for precise interrogation and modulation, conventional non-degradable designs pose limited utilization in nerve injury rehabilitation. Here, we introduce a biodegradable and restorative neural interface for wireless real-time tracking and recovery of long-gap nerve injuries. Leveraging machine learning techniques, this electronic platform deciphers nerve recovery status and identifies traumatic neuroma formation at the early phase, enabling timely intervention and significantly improved therapeutic outcomes. The biodegradable nature of the device eliminates the need for retrieval procedures, reducing infection risks and secondary tissue damage. This research sheds light on bioresorbable multifunctional peripheral nerve interfaces for probing neuropathic injuries, offering vital information for early diagnosis and therapeutic intervention. |
| format | Article |
| id | doaj-art-ded3b1bc802a40f783d35c0d9aa7a61b |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-ded3b1bc802a40f783d35c0d9aa7a61b2025-08-20T02:15:16ZengNature PortfolioNature Communications2041-17232025-02-0116111610.1038/s41467-025-56089-1A biodegradable and restorative peripheral neural interface for the interrogation of neuropathic injuriesLiu Wang0Tieyuan Zhang1Jiaxin Lei2Shirong Wang3Yanjun Guan4Kuntao Chen5Chaochao Li6Yahao Song7Weining Li8Shimeng Wang9Zhibo Jia10Shengfeng Chen11Jun Bai12Bingbing Yu13Can Yang14Pengcheng Sun15Qingyun Wang16Xing Sheng17Jiang Peng18Yubo Fan19Lizhen Wang20Milin Zhang21Yu Wang22Lan Yin23Medical Engineering & Engineering Medicine Innovation Center of Hangzhou International Innovation Institute, Beihang UniversityInstitute of Orthopedics, Chinese PLA General HospitalDepartment of Electronic Engineering, Tsinghua UniversityMegaRobo Technologies Co. ltdInstitute of Orthopedics, Chinese PLA General HospitalSchool of Materials Science and Engineering, Tsinghua UniversityInstitute of Orthopedics, Chinese PLA General HospitalDepartment of Electronic Engineering, Tsinghua UniversityDepartment of Electronic Engineering, Tsinghua UniversityDepartment of Electronic Engineering, Tsinghua UniversityInstitute of Orthopedics, Chinese PLA General HospitalInstitute of Orthopedics, Chinese PLA General HospitalInstitute of Orthopedics, Chinese PLA General HospitalSchool of Materials Science and Engineering, Tsinghua UniversitySchool of Materials Science and Engineering, Tsinghua UniversitySchool of Materials Science and Engineering, Tsinghua UniversityDepartment of Dynamics and Control, Beihang UniversityDepartment of Electronic Engineering, Tsinghua UniversityInstitute of Orthopedics, Chinese PLA General HospitalMedical Engineering & Engineering Medicine Innovation Center of Hangzhou International Innovation Institute, Beihang UniversityMedical Engineering & Engineering Medicine Innovation Center of Hangzhou International Innovation Institute, Beihang UniversityDepartment of Electronic Engineering, Tsinghua UniversityInstitute of Orthopedics, Chinese PLA General HospitalSchool of Materials Science and Engineering, Tsinghua UniversityAbstract Monitoring the early-stage healing of severe traumatic nerve injuries is essential to gather physiological and pathological information for timely interventions and optimal clinical outcomes. Traditional diagnostic methods relying on physical examinations, imaging tools, and intraoperative electrophysiological testing present great challenges in continuous and remote monitoring. While implantable peripheral nerve interfaces provide direct access to nerve fibers for precise interrogation and modulation, conventional non-degradable designs pose limited utilization in nerve injury rehabilitation. Here, we introduce a biodegradable and restorative neural interface for wireless real-time tracking and recovery of long-gap nerve injuries. Leveraging machine learning techniques, this electronic platform deciphers nerve recovery status and identifies traumatic neuroma formation at the early phase, enabling timely intervention and significantly improved therapeutic outcomes. The biodegradable nature of the device eliminates the need for retrieval procedures, reducing infection risks and secondary tissue damage. This research sheds light on bioresorbable multifunctional peripheral nerve interfaces for probing neuropathic injuries, offering vital information for early diagnosis and therapeutic intervention.https://doi.org/10.1038/s41467-025-56089-1 |
| spellingShingle | Liu Wang Tieyuan Zhang Jiaxin Lei Shirong Wang Yanjun Guan Kuntao Chen Chaochao Li Yahao Song Weining Li Shimeng Wang Zhibo Jia Shengfeng Chen Jun Bai Bingbing Yu Can Yang Pengcheng Sun Qingyun Wang Xing Sheng Jiang Peng Yubo Fan Lizhen Wang Milin Zhang Yu Wang Lan Yin A biodegradable and restorative peripheral neural interface for the interrogation of neuropathic injuries Nature Communications |
| title | A biodegradable and restorative peripheral neural interface for the interrogation of neuropathic injuries |
| title_full | A biodegradable and restorative peripheral neural interface for the interrogation of neuropathic injuries |
| title_fullStr | A biodegradable and restorative peripheral neural interface for the interrogation of neuropathic injuries |
| title_full_unstemmed | A biodegradable and restorative peripheral neural interface for the interrogation of neuropathic injuries |
| title_short | A biodegradable and restorative peripheral neural interface for the interrogation of neuropathic injuries |
| title_sort | biodegradable and restorative peripheral neural interface for the interrogation of neuropathic injuries |
| url | https://doi.org/10.1038/s41467-025-56089-1 |
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