Glutamate Receptor Signaling in Retina Müller Cells: Plausible Role in Neurodegeneration
The retinal network relies on glutamate, the primary excitatory neurotransmitter involved in the visual cycle. Glutamate transactions are carried out by an array of distinct receptors and transporters distributed across both pre- and post-synaptic neurons and Müller radial glial cells. Glutamate rec...
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MDPI AG
2025-02-01
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| author | Bolaji Oyetayo Yurixy Mendoza-Silva Temitayo Subair Luisa C Hernández-Kelly Marie-Paule Felder-Schmittbuhl Tatiana N. Olivares-Bañuelos Arturo Ortega |
| author_facet | Bolaji Oyetayo Yurixy Mendoza-Silva Temitayo Subair Luisa C Hernández-Kelly Marie-Paule Felder-Schmittbuhl Tatiana N. Olivares-Bañuelos Arturo Ortega |
| author_sort | Bolaji Oyetayo |
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| description | The retinal network relies on glutamate, the primary excitatory neurotransmitter involved in the visual cycle. Glutamate transactions are carried out by an array of distinct receptors and transporters distributed across both pre- and post-synaptic neurons and Müller radial glial cells. Glutamate receptors are broadly divided into two types: ionotropic and metabotropic receptors that differ in their molecular architecture and signaling properties. Within the retina, Müller glia cells span across its entire layers and possess specialized features that enable them to regulate glutamate extracellular levels and thus, its neuronal availability. In order to prevent an excitotoxic insult, retina extracellular glutamate levels have to be tightly regulated through uptake, predominantly into Müller glial cells, by a family of Na<sup>+</sup>-dependent glutamate transporters known as excitatory amino acid transporters. An exquisite interplay between glutamate receptor signaling and glutamate transporter expression and function is fundamental for the integrity and proper function of the retina. This review examines our current understanding of the impact of Müller glial glutamate signaling on glia/neuronal coupling. |
| format | Article |
| id | doaj-art-ded212f8abb64cc2ada8df76f393999a |
| institution | OA Journals |
| issn | 2813-2564 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Receptors |
| spelling | doaj-art-ded212f8abb64cc2ada8df76f393999a2025-08-20T01:48:49ZengMDPI AGReceptors2813-25642025-02-0141410.3390/receptors4010004Glutamate Receptor Signaling in Retina Müller Cells: Plausible Role in NeurodegenerationBolaji Oyetayo0Yurixy Mendoza-Silva1Temitayo Subair2Luisa C Hernández-Kelly3Marie-Paule Felder-Schmittbuhl4Tatiana N. Olivares-Bañuelos5Arturo Ortega6Department of Toxicology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. IPN 2508, Mexico City 07360, MexicoDepartment of Toxicology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. IPN 2508, Mexico City 07360, MexicoDepartment of Toxicology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. IPN 2508, Mexico City 07360, MexicoDepartment of Toxicology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. IPN 2508, Mexico City 07360, MexicoCentre National de la Recherche Scientifique, Institute of Cellular and Integrative Neurosciences (UPR 3212), Université de Strasbourg, 67081 Strasbourg, FranceInstituto de Investigaciones Oceanológicas, Universidad Autónoma de Baja California, Carretera Ensenada-Tijuana No. 3917, Fracc. Playitas, Ensenada 22860, MexicoDepartment of Toxicology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. IPN 2508, Mexico City 07360, MexicoThe retinal network relies on glutamate, the primary excitatory neurotransmitter involved in the visual cycle. Glutamate transactions are carried out by an array of distinct receptors and transporters distributed across both pre- and post-synaptic neurons and Müller radial glial cells. Glutamate receptors are broadly divided into two types: ionotropic and metabotropic receptors that differ in their molecular architecture and signaling properties. Within the retina, Müller glia cells span across its entire layers and possess specialized features that enable them to regulate glutamate extracellular levels and thus, its neuronal availability. In order to prevent an excitotoxic insult, retina extracellular glutamate levels have to be tightly regulated through uptake, predominantly into Müller glial cells, by a family of Na<sup>+</sup>-dependent glutamate transporters known as excitatory amino acid transporters. An exquisite interplay between glutamate receptor signaling and glutamate transporter expression and function is fundamental for the integrity and proper function of the retina. This review examines our current understanding of the impact of Müller glial glutamate signaling on glia/neuronal coupling.https://www.mdpi.com/2813-2564/4/1/4excitotoxicitygene expressionglutamateMüller cellsreceptorretina |
| spellingShingle | Bolaji Oyetayo Yurixy Mendoza-Silva Temitayo Subair Luisa C Hernández-Kelly Marie-Paule Felder-Schmittbuhl Tatiana N. Olivares-Bañuelos Arturo Ortega Glutamate Receptor Signaling in Retina Müller Cells: Plausible Role in Neurodegeneration Receptors excitotoxicity gene expression glutamate Müller cells receptor retina |
| title | Glutamate Receptor Signaling in Retina Müller Cells: Plausible Role in Neurodegeneration |
| title_full | Glutamate Receptor Signaling in Retina Müller Cells: Plausible Role in Neurodegeneration |
| title_fullStr | Glutamate Receptor Signaling in Retina Müller Cells: Plausible Role in Neurodegeneration |
| title_full_unstemmed | Glutamate Receptor Signaling in Retina Müller Cells: Plausible Role in Neurodegeneration |
| title_short | Glutamate Receptor Signaling in Retina Müller Cells: Plausible Role in Neurodegeneration |
| title_sort | glutamate receptor signaling in retina muller cells plausible role in neurodegeneration |
| topic | excitotoxicity gene expression glutamate Müller cells receptor retina |
| url | https://www.mdpi.com/2813-2564/4/1/4 |
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