Advances in Gene Therapy for Neurologic Disorders: An Overview
Neurologic disorders currently affect approximately 100 million people worldwide. Neurologic disorders most often occur due to inherent genetic mutations, which lead to numerous types of functional disruptions in nervous system development. Neurologic disease-related events, such as genetic and epig...
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| Format: | Article |
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2025-02-01
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| Series: | BIO Integration |
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| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/bioi-2024-0060 |
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| author | Pallavi Chand K. Trideva Sastri Ashish Singh Chauhan Souvik Chakraborty Vikash Jakhmola |
| author_facet | Pallavi Chand K. Trideva Sastri Ashish Singh Chauhan Souvik Chakraborty Vikash Jakhmola |
| author_sort | Pallavi Chand |
| collection | DOAJ |
| description | Neurologic disorders currently affect approximately 100 million people worldwide. Neurologic disorders most often occur due to inherent genetic mutations, which lead to numerous types of functional disruptions in nervous system development. Neurologic disease-related events, such as genetic and epigenetic changes, cause inflammatory processes in the area which may enhance the disease cycle. Gene therapy has progressed to a compelling therapeutic approach for various neurodegenerative disorders. Several efforts to enhance gene therapy rely on discovering novel vectors, recent curative targets, and the dependability of transgenic delivery paths. These viral and non-viral vectors techniques are carefully screened through preclinical and clinical levels and eventually render patients with effective therapies. This review addresses gene therapy developments and obstacles for neurodegenerative diseases and discusses emerging strategies, goals, and prospects. |
| format | Article |
| id | doaj-art-ded1d08752ad43cf916e5f271b075c7e |
| institution | Kabale University |
| issn | 2712-0082 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | BIO Integration |
| spelling | doaj-art-ded1d08752ad43cf916e5f271b075c7e2025-02-07T12:22:18ZengCompuscript LtdBIO Integration2712-00822025-02-016110.15212/bioi-2024-0060Advances in Gene Therapy for Neurologic Disorders: An OverviewPallavi Chand0K. Trideva Sastri1Ashish Singh Chauhan2Souvik Chakraborty3Vikash Jakhmola4Department of Pharmaceutics, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun 248007, Uttarakhand, IndiaDepartment of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka, IndiaDepartment of Pharmaceutics, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun 248007, Uttarakhand, IndiaDepartment of Pharmaceutics, Eminent College of Pharmaceutical Technology, Barbaria, Jagannathpur, Barasat, WB, IndiaDepartment of Pharmaceutical Chemistry, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun 248007, Uttarakhand, IndiaNeurologic disorders currently affect approximately 100 million people worldwide. Neurologic disorders most often occur due to inherent genetic mutations, which lead to numerous types of functional disruptions in nervous system development. Neurologic disease-related events, such as genetic and epigenetic changes, cause inflammatory processes in the area which may enhance the disease cycle. Gene therapy has progressed to a compelling therapeutic approach for various neurodegenerative disorders. Several efforts to enhance gene therapy rely on discovering novel vectors, recent curative targets, and the dependability of transgenic delivery paths. These viral and non-viral vectors techniques are carefully screened through preclinical and clinical levels and eventually render patients with effective therapies. This review addresses gene therapy developments and obstacles for neurodegenerative diseases and discusses emerging strategies, goals, and prospects.https://www.scienceopen.com/hosted-document?doi=10.15212/bioi-2024-0060adeno-associated virusesgene therapylipid-based vectorsneurologic disordersnon-viral and viral vectors |
| spellingShingle | Pallavi Chand K. Trideva Sastri Ashish Singh Chauhan Souvik Chakraborty Vikash Jakhmola Advances in Gene Therapy for Neurologic Disorders: An Overview BIO Integration adeno-associated viruses gene therapy lipid-based vectors neurologic disorders non-viral and viral vectors |
| title | Advances in Gene Therapy for Neurologic Disorders: An Overview |
| title_full | Advances in Gene Therapy for Neurologic Disorders: An Overview |
| title_fullStr | Advances in Gene Therapy for Neurologic Disorders: An Overview |
| title_full_unstemmed | Advances in Gene Therapy for Neurologic Disorders: An Overview |
| title_short | Advances in Gene Therapy for Neurologic Disorders: An Overview |
| title_sort | advances in gene therapy for neurologic disorders an overview |
| topic | adeno-associated viruses gene therapy lipid-based vectors neurologic disorders non-viral and viral vectors |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/bioi-2024-0060 |
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