The epithelial era of asthma research: knowledge gaps and future direction for patient care
The Epithelial Science Expert Group convened on 18–19 October 2023, in Naples, Italy, to discuss the current understanding of the fundamental role of the airway epithelium in asthma and other respiratory diseases and to explore the future direction of patient care. This review summarises the key con...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2024-12-01
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| Series: | European Respiratory Review |
| Online Access: | http://err.ersjournals.com/content/33/174/240221.full |
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| author | Christopher E. Brightling Gianni Marone Helena Aegerter Pascal Chanez Enrico Heffler Ian D. Pavord Klaus F. Rabe Lena Uller Del Dorscheid the Epithelial Science Expert Group Helena Aegerter Arnaud Bourdin Christopher E Brightling Marco Caminati Pascal Chanez Del Dorscheid Julia Eckl-Dorna Ibon Eguiluz-Gracia Enrico Heffler Pieter Hiemstra Gianni Marone Oscar Palomares Ian D. Pavord Remo Poto Klaus F. Rabe Lena Uller Gilda Varricchi |
| author_facet | Christopher E. Brightling Gianni Marone Helena Aegerter Pascal Chanez Enrico Heffler Ian D. Pavord Klaus F. Rabe Lena Uller Del Dorscheid the Epithelial Science Expert Group Helena Aegerter Arnaud Bourdin Christopher E Brightling Marco Caminati Pascal Chanez Del Dorscheid Julia Eckl-Dorna Ibon Eguiluz-Gracia Enrico Heffler Pieter Hiemstra Gianni Marone Oscar Palomares Ian D. Pavord Remo Poto Klaus F. Rabe Lena Uller Gilda Varricchi |
| author_sort | Christopher E. Brightling |
| collection | DOAJ |
| description | The Epithelial Science Expert Group convened on 18–19 October 2023, in Naples, Italy, to discuss the current understanding of the fundamental role of the airway epithelium in asthma and other respiratory diseases and to explore the future direction of patient care. This review summarises the key concepts and research questions that were raised. As an introduction to the epithelial era of research, the evolution of asthma management throughout the ages was discussed and the role of the epithelium as an immune-functioning organ was elucidated. The role of the bronchial epithelial cells in lower airway diseases beyond severe asthma was considered, as well as the role of the epithelium in upper airway diseases such as chronic rhinosinusitis. The biology and application of biomarkers in patient care was also discussed. The Epithelial Science Expert Group also explored future research needs by identifying the current knowledge and research gaps in asthma management and ranking them by priority. It was identified that there is a need to define and support early assessment of asthma to characterise patients at high risk of severe asthma. Furthermore, a better understanding of asthma progression is required. The development of new treatments and diagnostic tests as well as the identification of new biomarkers will also be required to address the current unmet needs. Finally, an increased understanding of epithelial dysfunction will determine if we can alter disease progression and achieve clinical remission. |
| format | Article |
| id | doaj-art-decf48b9b24d40b183d0ff44b3cbd9cf |
| institution | DOAJ |
| issn | 0905-9180 1600-0617 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj-art-decf48b9b24d40b183d0ff44b3cbd9cf2025-08-20T02:42:57ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172024-12-013317410.1183/16000617.0221-20240221-2024The epithelial era of asthma research: knowledge gaps and future direction for patient careChristopher E. Brightling0Gianni Marone1Helena Aegerter2Pascal Chanez3Enrico Heffler4Ian D. Pavord5Klaus F. Rabe6Lena Uller7Del Dorscheid8the Epithelial Science Expert GroupHelena AegerterArnaud BourdinChristopher E BrightlingMarco CaminatiPascal ChanezDel DorscheidJulia Eckl-DornaIbon Eguiluz-GraciaEnrico HefflerPieter HiemstraGianni MaroneOscar PalomaresIan D. PavordRemo PotoKlaus F. RabeLena UllerGilda Varricchi Institute for Lung Health, National Institute for Health and Care Research Leicester Biomedical Research Centre, University of Leicester, Leicester, UK Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research, School of Medicine, University of Naples Federico II, Naples, Italy Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium Department of Respiratory Diseases, Aix-Marseille University, Marseille, France Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy Respiratory Medicine, National Institute for Health and Care Research Oxford Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, UK LungenClinic Grosshansdorf, Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany Unit of Respiratory Immunopharmacology, Department of Experimental Medical Science, Lund University, Lund, Sweden Center for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, BC, Canada The Epithelial Science Expert Group convened on 18–19 October 2023, in Naples, Italy, to discuss the current understanding of the fundamental role of the airway epithelium in asthma and other respiratory diseases and to explore the future direction of patient care. This review summarises the key concepts and research questions that were raised. As an introduction to the epithelial era of research, the evolution of asthma management throughout the ages was discussed and the role of the epithelium as an immune-functioning organ was elucidated. The role of the bronchial epithelial cells in lower airway diseases beyond severe asthma was considered, as well as the role of the epithelium in upper airway diseases such as chronic rhinosinusitis. The biology and application of biomarkers in patient care was also discussed. The Epithelial Science Expert Group also explored future research needs by identifying the current knowledge and research gaps in asthma management and ranking them by priority. It was identified that there is a need to define and support early assessment of asthma to characterise patients at high risk of severe asthma. Furthermore, a better understanding of asthma progression is required. The development of new treatments and diagnostic tests as well as the identification of new biomarkers will also be required to address the current unmet needs. Finally, an increased understanding of epithelial dysfunction will determine if we can alter disease progression and achieve clinical remission.http://err.ersjournals.com/content/33/174/240221.full |
| spellingShingle | Christopher E. Brightling Gianni Marone Helena Aegerter Pascal Chanez Enrico Heffler Ian D. Pavord Klaus F. Rabe Lena Uller Del Dorscheid the Epithelial Science Expert Group Helena Aegerter Arnaud Bourdin Christopher E Brightling Marco Caminati Pascal Chanez Del Dorscheid Julia Eckl-Dorna Ibon Eguiluz-Gracia Enrico Heffler Pieter Hiemstra Gianni Marone Oscar Palomares Ian D. Pavord Remo Poto Klaus F. Rabe Lena Uller Gilda Varricchi The epithelial era of asthma research: knowledge gaps and future direction for patient care European Respiratory Review |
| title | The epithelial era of asthma research: knowledge gaps and future direction for patient care |
| title_full | The epithelial era of asthma research: knowledge gaps and future direction for patient care |
| title_fullStr | The epithelial era of asthma research: knowledge gaps and future direction for patient care |
| title_full_unstemmed | The epithelial era of asthma research: knowledge gaps and future direction for patient care |
| title_short | The epithelial era of asthma research: knowledge gaps and future direction for patient care |
| title_sort | epithelial era of asthma research knowledge gaps and future direction for patient care |
| url | http://err.ersjournals.com/content/33/174/240221.full |
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