Impact of conventional hemodialysis and hemoperfusion on microinflammation of patients with end-stage renal disease
Objective To observe the impact of conventional hemodialysis and hemoperfusion on micro-inflammatory state of patients with end-stage renal disease.Methods From January 2012 to October 2013 in our hospital,68 cases of end-stage renal disease were selected as the research subjects;32 cases subject to...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2015-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57921199&Fpath=home&index=0 |
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| Summary: | Objective To observe the impact of conventional hemodialysis and hemoperfusion on micro-inflammatory state of patients with end-stage renal disease.Methods From January 2012 to October 2013 in our hospital,68 cases of end-stage renal disease were selected as the research subjects;32 cases subject to conventional hemodialysis as the control group,and 36 cases subject to hemoperfusion as the observation group.The improvement data of renal function,micro-inflammatory state and quality of life of two groups before and after treatment were observed and compared.Results Before treatment,there was no significant difference in glomerular filtration rate,blood urea nitrogen and serum creatinine between two groups(P>0.05).After three months of treatment,the glomerular filtration rate was significantly increased,and blood urea nitrogen and serum creatinine were significantly reduced in two groups(P<0.05),and there was no significant difference between two groups(P>0.05).Before treatment,there was no significant difference in high-sensitivity C-reactive protein,homocysteine and procalcitonin between two groups(P>0.05).After three months of treatment,the high-sensitivity C-reactive protein,homocysteine,and procalcitonin in two groups were significantly reduced(P<0.05),and the difference was statistically significant between two groups(P<0.05).Before treatment,there was no significant difference in physical function status of patients[Karnofsky(KPS) scores],and psychological status[Hamilton Depression Scale(HAMD) scores]between two groups(P>0.05).After three months of treatment,the KPS scores and HAMD scores in two groups got significantly improved(P<0.05),and the difference was statistically significant between two groups <P<0.05).Conclusions Conventional hemodialysis and hemoperfusion can effectively improve renal function in patients with end-stage renal disease,but the latter is more satisfactory to improve the micro-inflammatory state and the quality of life of patients with end-stage renal disease,so it is the preferred treatment programs clinically. |
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| ISSN: | 1671-2390 |