Specificity of recovery in acute motor axonal neuropathy with conduction blocks on the example of two clinical cases
Introduction. The heterogeneity of the forms and severity of Guillain-Barre syndrome explains the variability of recovery: from rapid and complete (in most cases) to slow with the development of persistent residual deficiency (rarely). It is unclear how effective the Erasmus Guillain–Barre syndrome...
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2020-12-01
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| Series: | Нервно-мышечные болезни |
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| Online Access: | https://nmb.abvpress.ru/jour/article/view/407 |
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| author | D. A. Grishina N. A. Suponeva |
| author_facet | D. A. Grishina N. A. Suponeva |
| author_sort | D. A. Grishina |
| collection | DOAJ |
| description | Introduction. The heterogeneity of the forms and severity of Guillain-Barre syndrome explains the variability of recovery: from rapid and complete (in most cases) to slow with the development of persistent residual deficiency (rarely). It is unclear how effective the Erasmus Guillain–Barre syndrome Outcome Scores and its modified version are for different forms of the disease.The aim of the study – to demonstrate the features of recovery in acute motor axonal neuropathy with conduction blocks on the example of 2 clinical cases; to show the possibilities of Erasmus Guillain–Barre syndrome Outcome Scores and its modified version in predicting recovery in this form of the disease.Materials and methods. Data from 2 patients with acute motor axonal neuropathy with motor conduction blocks were retrospectively analyzed. Calculation of the score and assessment of the prognosis of walking recovery by 6 months from the onset of the disease were performed using the online calculator International Guillain-Barre syndrome Outcome Study Prognosis tool in the acute period.Results. In both patients, the forecast of recovery of walking by half a year from the onset of the disease on the Erasmus Guillain–Barre syndrome Outcome Scores and modified Erasmus Guillain–Barre syndrome Outcome Scores scales in the acute period was erroneous. In the first case, the total score on the Erasmus Guillain–Barre syndrome Outcome Scores and its modification in the acute period was 5 and 10 points respectively (poor prognosis), which foreshadowed a long rehabilitation process and incomplete recovery. However, the regression of disorders was dramatic and complete, and by the second month of the disease, only minimal motor disorders remained. In the second patient, on the contrary, the total Erasmus Guillain–Barre syndrome Outcome Scores and its modification during the period of increasing symptoms was 3 and 7 points respectively (good prognosis), while recovery was delayed – only by 5 months from the onset of the disease, the ability to move with support was restored.Conclusion. The Guillain–Barre syndrome is a disease with a favorable prognosis for recovery. However, the prediction of regression of motor disorders should be approached carefully, because in some cases, generally accepted criteria and prognostic scales may not work. Acute motor axonal neuropathy with conduction blocks is a unique form of the disease that has pathophysiological and clinical-neurophysiological features, which should be taken into account when managing this category of patients. |
| format | Article |
| id | doaj-art-decdd1236daf43d997686163f2365af2 |
| institution | Kabale University |
| issn | 2222-8721 2413-0443 |
| language | Russian |
| publishDate | 2020-12-01 |
| publisher | ABV-press |
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| series | Нервно-мышечные болезни |
| spelling | doaj-art-decdd1236daf43d997686163f2365af22025-08-20T03:37:12ZrusABV-pressНервно-мышечные болезни2222-87212413-04432020-12-01104435110.17650/2222-8721-2020-10-4-43-51283Specificity of recovery in acute motor axonal neuropathy with conduction blocks on the example of two clinical casesD. A. Grishina0N. A. Suponeva1Research Center of NeurologyResearch Center of NeurologyIntroduction. The heterogeneity of the forms and severity of Guillain-Barre syndrome explains the variability of recovery: from rapid and complete (in most cases) to slow with the development of persistent residual deficiency (rarely). It is unclear how effective the Erasmus Guillain–Barre syndrome Outcome Scores and its modified version are for different forms of the disease.The aim of the study – to demonstrate the features of recovery in acute motor axonal neuropathy with conduction blocks on the example of 2 clinical cases; to show the possibilities of Erasmus Guillain–Barre syndrome Outcome Scores and its modified version in predicting recovery in this form of the disease.Materials and methods. Data from 2 patients with acute motor axonal neuropathy with motor conduction blocks were retrospectively analyzed. Calculation of the score and assessment of the prognosis of walking recovery by 6 months from the onset of the disease were performed using the online calculator International Guillain-Barre syndrome Outcome Study Prognosis tool in the acute period.Results. In both patients, the forecast of recovery of walking by half a year from the onset of the disease on the Erasmus Guillain–Barre syndrome Outcome Scores and modified Erasmus Guillain–Barre syndrome Outcome Scores scales in the acute period was erroneous. In the first case, the total score on the Erasmus Guillain–Barre syndrome Outcome Scores and its modification in the acute period was 5 and 10 points respectively (poor prognosis), which foreshadowed a long rehabilitation process and incomplete recovery. However, the regression of disorders was dramatic and complete, and by the second month of the disease, only minimal motor disorders remained. In the second patient, on the contrary, the total Erasmus Guillain–Barre syndrome Outcome Scores and its modification during the period of increasing symptoms was 3 and 7 points respectively (good prognosis), while recovery was delayed – only by 5 months from the onset of the disease, the ability to move with support was restored.Conclusion. The Guillain–Barre syndrome is a disease with a favorable prognosis for recovery. However, the prediction of regression of motor disorders should be approached carefully, because in some cases, generally accepted criteria and prognostic scales may not work. Acute motor axonal neuropathy with conduction blocks is a unique form of the disease that has pathophysiological and clinical-neurophysiological features, which should be taken into account when managing this category of patients.https://nmb.abvpress.ru/jour/article/view/407acute motor axonal neuropathyconduction blockguillain–barre syndromeprognosisrecoveryprognostic scaleegosmegos |
| spellingShingle | D. A. Grishina N. A. Suponeva Specificity of recovery in acute motor axonal neuropathy with conduction blocks on the example of two clinical cases Нервно-мышечные болезни acute motor axonal neuropathy conduction block guillain–barre syndrome prognosis recovery prognostic scale egos megos |
| title | Specificity of recovery in acute motor axonal neuropathy with conduction blocks on the example of two clinical cases |
| title_full | Specificity of recovery in acute motor axonal neuropathy with conduction blocks on the example of two clinical cases |
| title_fullStr | Specificity of recovery in acute motor axonal neuropathy with conduction blocks on the example of two clinical cases |
| title_full_unstemmed | Specificity of recovery in acute motor axonal neuropathy with conduction blocks on the example of two clinical cases |
| title_short | Specificity of recovery in acute motor axonal neuropathy with conduction blocks on the example of two clinical cases |
| title_sort | specificity of recovery in acute motor axonal neuropathy with conduction blocks on the example of two clinical cases |
| topic | acute motor axonal neuropathy conduction block guillain–barre syndrome prognosis recovery prognostic scale egos megos |
| url | https://nmb.abvpress.ru/jour/article/view/407 |
| work_keys_str_mv | AT dagrishina specificityofrecoveryinacutemotoraxonalneuropathywithconductionblocksontheexampleoftwoclinicalcases AT nasuponeva specificityofrecoveryinacutemotoraxonalneuropathywithconductionblocksontheexampleoftwoclinicalcases |