Clinical and Pathological Spectrum of Hepatoblastoma with Emphasis on Treatment-Induced Changes: Experience from Tertiary Care Center
Introduction Hepatoblastoma is a rare pediatric liver tumor. Advances in imaging/surgical techniques and use of neoadjuvant chemotherapy (NACT) in recent times have resulted in improved survival of children with hepatoblastoma. Yet it has dismal prognosis in some children. Unlike other pe...
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1801884 |
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| author | Divya Achutha Ail Malini Eapen Pavithran Keechilat Sudheendran Surendran Naveen Viswanath |
| author_facet | Divya Achutha Ail Malini Eapen Pavithran Keechilat Sudheendran Surendran Naveen Viswanath |
| author_sort | Divya Achutha Ail |
| collection | DOAJ |
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Introduction Hepatoblastoma is a rare pediatric liver tumor. Advances in imaging/surgical techniques and use of neoadjuvant chemotherapy (NACT) in recent times have resulted in improved survival of children with hepatoblastoma. Yet it has dismal prognosis in some children. Unlike other pediatric malignant tumors, pathological tumor regression grading in hepatoblastoma following NACT is not in routine practice. Assessing tumor-induced maturation and delineating it from non-neoplastic liver at resection margin are often challenging in this setting. |
| format | Article |
| id | doaj-art-decdcddf38b44d26aab7904b3387b106 |
| institution | OA Journals |
| issn | 0971-5851 0975-2129 |
| language | English |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-decdcddf38b44d26aab7904b3387b1062025-08-20T02:32:44ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-212910.1055/s-0045-1801884Clinical and Pathological Spectrum of Hepatoblastoma with Emphasis on Treatment-Induced Changes: Experience from Tertiary Care CenterDivya Achutha Ail0Malini Eapen1https://orcid.org/0000-0002-2849-4570Pavithran Keechilat2Sudheendran Surendran3Naveen Viswanath4Department of Pathology, Yenepoya Medical College (Deemed to be University), Mangalore, Karnataka, IndiaDepartment of Pathology, Amrita Institute of Medical Sciences, Kochi, Kerala, IndiaDepartment of Medical Oncology, Amrita Institute of Medical Science and Research Centre, Kochi, Kerala, IndiaDepartment of GI Surgery, Solid Organ Transplant Institute, Amrita Institute of Medical Science and Research Centre, Kochi, Kerala, IndiaDepartment of Paediatric Surgery, Amrita Institute of Medical Science and Research Centre, Kochi, Kerala, India Introduction Hepatoblastoma is a rare pediatric liver tumor. Advances in imaging/surgical techniques and use of neoadjuvant chemotherapy (NACT) in recent times have resulted in improved survival of children with hepatoblastoma. Yet it has dismal prognosis in some children. Unlike other pediatric malignant tumors, pathological tumor regression grading in hepatoblastoma following NACT is not in routine practice. Assessing tumor-induced maturation and delineating it from non-neoplastic liver at resection margin are often challenging in this setting.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1801884hepatoblastomachildliver neoplasmneoadjuvant therapyimmunohistochemistryprognosis |
| spellingShingle | Divya Achutha Ail Malini Eapen Pavithran Keechilat Sudheendran Surendran Naveen Viswanath Clinical and Pathological Spectrum of Hepatoblastoma with Emphasis on Treatment-Induced Changes: Experience from Tertiary Care Center Indian Journal of Medical and Paediatric Oncology hepatoblastoma child liver neoplasm neoadjuvant therapy immunohistochemistry prognosis |
| title | Clinical and Pathological Spectrum of Hepatoblastoma with Emphasis on Treatment-Induced Changes: Experience from Tertiary Care Center |
| title_full | Clinical and Pathological Spectrum of Hepatoblastoma with Emphasis on Treatment-Induced Changes: Experience from Tertiary Care Center |
| title_fullStr | Clinical and Pathological Spectrum of Hepatoblastoma with Emphasis on Treatment-Induced Changes: Experience from Tertiary Care Center |
| title_full_unstemmed | Clinical and Pathological Spectrum of Hepatoblastoma with Emphasis on Treatment-Induced Changes: Experience from Tertiary Care Center |
| title_short | Clinical and Pathological Spectrum of Hepatoblastoma with Emphasis on Treatment-Induced Changes: Experience from Tertiary Care Center |
| title_sort | clinical and pathological spectrum of hepatoblastoma with emphasis on treatment induced changes experience from tertiary care center |
| topic | hepatoblastoma child liver neoplasm neoadjuvant therapy immunohistochemistry prognosis |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1801884 |
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