A randomized, open-label, two-period crossover study to evaluate the bioequivalence and food effect between two formulations of regorafenib in healthy adult participants

A randomized, open-label, two-period crossover study to evaluate the bioequivalence and food effect between two formulations of regorafenib in healthy adult participants

BackgroundThis research aimed to compare the bioequivalence of a test formulation (regorafenib produced by Beijing SL Pharmaceutical Co., Ltd.) with a reference formulation (the original drug Stivarga®) in Chinese healthy subjects under fasting conditions and two postprandial states: after low-fat a...

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Bibliographic Details
Main Authors: Yan Li, Lu Qi, Caixia Yang, Na Zhao, Xinghe Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
bioequivalence
food effect
pharmacokinetics
healthy subjects
regorafenib
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1511558/full
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