Pharmacological modulation of Sigma-1 receptor ameliorates pathological neuroinflammation in rats with diabetic neuropathic pain via the AKT/GSK-3β/NF-κB pathway
Diabetic neuropathic pain (DNP) is a common complication of diabetes mellitus (DM) and is characterized by spontaneous pain and neuroinflammation. The Sigma-1 receptor (Sig-1R) has been proposed as a target for analgesic development. It is an important receptor with anti-inflammatory properties and...
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Main Authors: | Yuyu An, Shanshan Cao, Leilei Shi, Yuhan Zhang, Xin Wang, Shiyu Yuan, Yongheng Shi, Bin Wang, Jiping Liu, Chao-jun Han |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2025-02-01
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Series: | Brain Research Bulletin |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025000383 |
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