Application of a simple scoring scale to predict prognosis of poor-grade subarachnoid haemorrhage using intraventricular haemorrhage
Abstract Intraventricular haemorrhage (IVH) is a key prognostic factor for subarachnoid haemorrhage (SAH). However, no simple or rapid scoring method for its evaluation exists. We aimed to modify and validate a simple scale for rapid IVH grading. We engaged two study groups to generate scores and ex...
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2025-04-01
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| author | Shuto Fushimi Taisuke Akimoto Makoto Ohtake Yu Iida Shigeta Miyake Ryosuke Suzuki Satoshi Hori Jun Suenaga Yasunobu Nakai Katsumi Sakata Tetsuya Yamamoto |
| author_facet | Shuto Fushimi Taisuke Akimoto Makoto Ohtake Yu Iida Shigeta Miyake Ryosuke Suzuki Satoshi Hori Jun Suenaga Yasunobu Nakai Katsumi Sakata Tetsuya Yamamoto |
| author_sort | Shuto Fushimi |
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| description | Abstract Intraventricular haemorrhage (IVH) is a key prognostic factor for subarachnoid haemorrhage (SAH). However, no simple or rapid scoring method for its evaluation exists. We aimed to modify and validate a simple scale for rapid IVH grading. We engaged two study groups to generate scores and examine their utility. Study 1 identified prognostic factors in poor-grade SAH and developed a prognostic scoring system. Study 2 evaluated the utility of the score by analysing data from a multicentre patient registry, including all severity levels, and confirmed its generalisability. Outcomes were defined using the modified Rankin scale (score ≥ 3: poor outcome). Study 1 (including 110 patients with poor-grade SAH) created a simple IVH score (IVHAge) based on two slices of computed tomography images and confirmed that it was as predictive as the modified Graeb score (area under the curve: IVHAge score, 0.815; modified Graeb score, 0.752). Study 2 examined 493 patients and found that for each 1-unit increase in the IVHAge score, the odds of a poor outcome increased by 37% (unit odds ratio, 1.37; 95% confidence interval 1.10–1.70; P = 0.005). The IVHAge score, which comprises a simplified IVH score and age-related factors, has prognostic value and is suitable for rapid clinical application. |
| format | Article |
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| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-dec2d1a8c17043678ff3ea6a78b7330c2025-08-20T02:55:21ZengNature PortfolioScientific Reports2045-23222025-04-011511910.1038/s41598-025-99132-3Application of a simple scoring scale to predict prognosis of poor-grade subarachnoid haemorrhage using intraventricular haemorrhageShuto Fushimi0Taisuke Akimoto1Makoto Ohtake2Yu Iida3Shigeta Miyake4Ryosuke Suzuki5Satoshi Hori6Jun Suenaga7Yasunobu Nakai8Katsumi Sakata9Tetsuya Yamamoto10Department of Neurosurgery, Yokohama City University Graduate School of MedicineDepartment of Neurosurgery, Yokohama City University Graduate School of MedicineDepartment of Neurosurgery, Yokohama City University Graduate School of MedicineDepartment of Neurosurgery, Yokohama City University Graduate School of MedicineDepartment of Neurosurgery, Yokohama City University Graduate School of MedicineDepartment of Neurosurgery, Yokohama City University Graduate School of MedicineDepartment of Neurosurgery, Yokohama City University Graduate School of MedicineDepartment of Neurosurgery, Yokohama City University Graduate School of MedicineDepartment of Neurosurgery, Yokohama City University Graduate School of MedicineDepartment of Neurosurgery, Yokohama City University Medical CenterDepartment of Neurosurgery, Yokohama City University Graduate School of MedicineAbstract Intraventricular haemorrhage (IVH) is a key prognostic factor for subarachnoid haemorrhage (SAH). However, no simple or rapid scoring method for its evaluation exists. We aimed to modify and validate a simple scale for rapid IVH grading. We engaged two study groups to generate scores and examine their utility. Study 1 identified prognostic factors in poor-grade SAH and developed a prognostic scoring system. Study 2 evaluated the utility of the score by analysing data from a multicentre patient registry, including all severity levels, and confirmed its generalisability. Outcomes were defined using the modified Rankin scale (score ≥ 3: poor outcome). Study 1 (including 110 patients with poor-grade SAH) created a simple IVH score (IVHAge) based on two slices of computed tomography images and confirmed that it was as predictive as the modified Graeb score (area under the curve: IVHAge score, 0.815; modified Graeb score, 0.752). Study 2 examined 493 patients and found that for each 1-unit increase in the IVHAge score, the odds of a poor outcome increased by 37% (unit odds ratio, 1.37; 95% confidence interval 1.10–1.70; P = 0.005). The IVHAge score, which comprises a simplified IVH score and age-related factors, has prognostic value and is suitable for rapid clinical application.https://doi.org/10.1038/s41598-025-99132-3Endovascular treatmentGraeb scoreIntraventricular haemorrhagePrognostic factorSubarachnoid haemorrhagePrognostic factor |
| spellingShingle | Shuto Fushimi Taisuke Akimoto Makoto Ohtake Yu Iida Shigeta Miyake Ryosuke Suzuki Satoshi Hori Jun Suenaga Yasunobu Nakai Katsumi Sakata Tetsuya Yamamoto Application of a simple scoring scale to predict prognosis of poor-grade subarachnoid haemorrhage using intraventricular haemorrhage Scientific Reports Endovascular treatment Graeb score Intraventricular haemorrhage Prognostic factor Subarachnoid haemorrhage Prognostic factor |
| title | Application of a simple scoring scale to predict prognosis of poor-grade subarachnoid haemorrhage using intraventricular haemorrhage |
| title_full | Application of a simple scoring scale to predict prognosis of poor-grade subarachnoid haemorrhage using intraventricular haemorrhage |
| title_fullStr | Application of a simple scoring scale to predict prognosis of poor-grade subarachnoid haemorrhage using intraventricular haemorrhage |
| title_full_unstemmed | Application of a simple scoring scale to predict prognosis of poor-grade subarachnoid haemorrhage using intraventricular haemorrhage |
| title_short | Application of a simple scoring scale to predict prognosis of poor-grade subarachnoid haemorrhage using intraventricular haemorrhage |
| title_sort | application of a simple scoring scale to predict prognosis of poor grade subarachnoid haemorrhage using intraventricular haemorrhage |
| topic | Endovascular treatment Graeb score Intraventricular haemorrhage Prognostic factor Subarachnoid haemorrhage Prognostic factor |
| url | https://doi.org/10.1038/s41598-025-99132-3 |
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