Relationship between immunohistochemical markers and clinical pathological variables in clear cell renal cell carcinoma
ObjectiveTo explore the factors associated with the immunohistochemical results in clear cell renal cell carcinoma (ccRCC).MethodsThis retrospective, single-center observational study included patients with pathologically confirmed ccRCC who underwent nephrectomy at Xingtai People’s Hospital between...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1580024/full |
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| author | Pengshuai Liu Pengshuai Liu Junli Wei Shubo Chen |
| author_facet | Pengshuai Liu Pengshuai Liu Junli Wei Shubo Chen |
| author_sort | Pengshuai Liu |
| collection | DOAJ |
| description | ObjectiveTo explore the factors associated with the immunohistochemical results in clear cell renal cell carcinoma (ccRCC).MethodsThis retrospective, single-center observational study included patients with pathologically confirmed ccRCC who underwent nephrectomy at Xingtai People’s Hospital between January 2023 and October 2024. Logistic and linear regression was used to evaluate predictors of ccRCC features, with adjustments for demographic and clinical factors.ResultAmong the 50 patients (median age, 66 years; 64% male), high Vimentin expression was significantly associated with vascular invasion (adjusted OR, 2.90; 95% CI, 1.05–7.62; P = 0.031), lymph node metastasis (OR, 2.62; 95% CI, 1.03–8.12; P = 0.042), distant metastasis (OR, 3.10; 95% CI, 1.01–12.54; P = 0.048), and larger tumor size (P = 0.004). Ki−67 expression varied significantly by alcohol consumption (P = 0.024), perineural invasion (P = 0.038), and was positively correlated with serum creatinine (P = 0.017). CD10 expression was inversely correlated with bilirubin levels (P = 0.021) but not associated with invasive or metastatic features.ConclusionVimentin expression was strongly associated with markers of tumor invasiveness and may serve as a practical prognostic biomarker in ccRCC. Ki-67 may reflect proliferative activity and systemic burden. CD10 remains diagnostically useful but lacks prognostic value. Incorporating these IHC markers into routine pathology assessment may enhance risk stratification and inform individualized management of ccRCC with more exploration and validation. |
| format | Article |
| id | doaj-art-debe879f28d045d795a9535200aab69f |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-debe879f28d045d795a9535200aab69f2025-08-20T03:57:31ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-08-011510.3389/fonc.2025.15800241580024Relationship between immunohistochemical markers and clinical pathological variables in clear cell renal cell carcinomaPengshuai Liu0Pengshuai Liu1Junli Wei2Shubo Chen3Department of Surgery, Graduate School of Chengde Medical College, Chengde, Hebei, ChinaDepartment of Urology, Xingtai People’s Hospital, Xingtai, Hebei, ChinaDepartment of Urology, Xingtai People’s Hospital, Xingtai, Hebei, ChinaDepartment of Urology, Xingtai People’s Hospital, Xingtai, Hebei, ChinaObjectiveTo explore the factors associated with the immunohistochemical results in clear cell renal cell carcinoma (ccRCC).MethodsThis retrospective, single-center observational study included patients with pathologically confirmed ccRCC who underwent nephrectomy at Xingtai People’s Hospital between January 2023 and October 2024. Logistic and linear regression was used to evaluate predictors of ccRCC features, with adjustments for demographic and clinical factors.ResultAmong the 50 patients (median age, 66 years; 64% male), high Vimentin expression was significantly associated with vascular invasion (adjusted OR, 2.90; 95% CI, 1.05–7.62; P = 0.031), lymph node metastasis (OR, 2.62; 95% CI, 1.03–8.12; P = 0.042), distant metastasis (OR, 3.10; 95% CI, 1.01–12.54; P = 0.048), and larger tumor size (P = 0.004). Ki−67 expression varied significantly by alcohol consumption (P = 0.024), perineural invasion (P = 0.038), and was positively correlated with serum creatinine (P = 0.017). CD10 expression was inversely correlated with bilirubin levels (P = 0.021) but not associated with invasive or metastatic features.ConclusionVimentin expression was strongly associated with markers of tumor invasiveness and may serve as a practical prognostic biomarker in ccRCC. Ki-67 may reflect proliferative activity and systemic burden. CD10 remains diagnostically useful but lacks prognostic value. Incorporating these IHC markers into routine pathology assessment may enhance risk stratification and inform individualized management of ccRCC with more exploration and validation.https://www.frontiersin.org/articles/10.3389/fonc.2025.1580024/fullclear cell renal cell carcinomaCD10VimentinKi-67biomarker |
| spellingShingle | Pengshuai Liu Pengshuai Liu Junli Wei Shubo Chen Relationship between immunohistochemical markers and clinical pathological variables in clear cell renal cell carcinoma Frontiers in Oncology clear cell renal cell carcinoma CD10 Vimentin Ki-67 biomarker |
| title | Relationship between immunohistochemical markers and clinical pathological variables in clear cell renal cell carcinoma |
| title_full | Relationship between immunohistochemical markers and clinical pathological variables in clear cell renal cell carcinoma |
| title_fullStr | Relationship between immunohistochemical markers and clinical pathological variables in clear cell renal cell carcinoma |
| title_full_unstemmed | Relationship between immunohistochemical markers and clinical pathological variables in clear cell renal cell carcinoma |
| title_short | Relationship between immunohistochemical markers and clinical pathological variables in clear cell renal cell carcinoma |
| title_sort | relationship between immunohistochemical markers and clinical pathological variables in clear cell renal cell carcinoma |
| topic | clear cell renal cell carcinoma CD10 Vimentin Ki-67 biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1580024/full |
| work_keys_str_mv | AT pengshuailiu relationshipbetweenimmunohistochemicalmarkersandclinicalpathologicalvariablesinclearcellrenalcellcarcinoma AT pengshuailiu relationshipbetweenimmunohistochemicalmarkersandclinicalpathologicalvariablesinclearcellrenalcellcarcinoma AT junliwei relationshipbetweenimmunohistochemicalmarkersandclinicalpathologicalvariablesinclearcellrenalcellcarcinoma AT shubochen relationshipbetweenimmunohistochemicalmarkersandclinicalpathologicalvariablesinclearcellrenalcellcarcinoma |