Using UV–Vis Titration to Elucidate Novel Epigallocatechin Gallate (EGCG)-Induced Binding of the c-MYC G-Quadruplex

Using UV–Vis Titration to Elucidate Novel Epigallocatechin Gallate (EGCG)-Induced Binding of the c-MYC G-Quadruplex

<b>Background/Objectives:</b> Aberrant expression of c-MYC drives aggressive cancers. A guanine-rich promoter sequence (Pu27) folds into a transcriptionally repressive G-quadruplex (G4). Epigallocatechin gallate (EGCG), the main green tea polyphenol, displays anticancer activity, but cle...

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Bibliographic Details
Main Author: Justin Tang
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceuticals
Subjects:
G-quadruplex
c-MYC
Epigallocatechin gallate (EGCG)
polyphenol
DNA binding
UV–Vis spectroscopy
Online Access:https://www.mdpi.com/1424-8247/18/5/719
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