Clinical Characteristics and Prognosis of AIDS Complicated with Talaromycosis marneffei Infection: a Single-Center Retrospective Study
Abstract Introduction The objective of the study was to determine the clinical features and prognostic risk factors of acquired immunodeficiency syndrome (AIDS) combined with Talaromyces marneffei (TM) infection. Methods We retrospectively analyzed the clinical data of 133 hospitalized patients diag...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Adis, Springer Healthcare
2025-07-01
|
| Series: | Infectious Diseases and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40121-025-01198-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849343110181552128 |
|---|---|
| author | Zhangyan Weng Yijie Lin Wenliang Dai Yijuan Zheng Huatang Zhang Minghui Zheng Haoyi He Youzhi Hong Dawu Zeng Zhijun Su Xueping Yu |
| author_facet | Zhangyan Weng Yijie Lin Wenliang Dai Yijuan Zheng Huatang Zhang Minghui Zheng Haoyi He Youzhi Hong Dawu Zeng Zhijun Su Xueping Yu |
| author_sort | Zhangyan Weng |
| collection | DOAJ |
| description | Abstract Introduction The objective of the study was to determine the clinical features and prognostic risk factors of acquired immunodeficiency syndrome (AIDS) combined with Talaromyces marneffei (TM) infection. Methods We retrospectively analyzed the clinical data of 133 hospitalized patients diagnosed with AIDS and TM co-infection. Patients were divided into an improvement group and a deterioration group on the basis of their discharge outcomes. To further investigate the severity of adverse outcomes, subgroup analysis was performed on the deterioration group. Due to the issue of complete separation in the data, Firth’s logistic regression model was employed to identify independent prognostic factors. Finally, the predictive performance of the model was evaluated using the receiver operating characteristic (ROC) curve. Results Among 133 patients with AIDS and TM co-infection, the main manifestations were fever (93.23%) and severe immunodeficiency with median CD4+ T cell count of 8.50 cells/μL, with blood culture showing the highest positive rate (93.85%). Firth’s logistic regression analysis revealed that timely antifungal therapy (OR 0.004, 95% CI <0.001–0.047, P < 0.001) and higher baseline albumin (ALB) levels (OR 0.858, 95% CI 0.732–0.973, P = 0.016) were independent protective factors for improving patient prognosis. The area under the receiver operating characteristic (ROC) curve (AUC) of the model was 0.930 (95% CI 0.878–0.982). Conclusions Timely antifungal therapy and good nutritional status are key determinants of prognosis in patients with AIDS and TM co-infection. Early diagnosis, prompt initiation of effective treatment, and active nutritional support are of great significance for improving patient survival outcomes. |
| format | Article |
| id | doaj-art-debe5d17d20c49c0a643ce46e0f060ac |
| institution | Kabale University |
| issn | 2193-8229 2193-6382 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Infectious Diseases and Therapy |
| spelling | doaj-art-debe5d17d20c49c0a643ce46e0f060ac2025-08-20T03:43:10ZengAdis, Springer HealthcareInfectious Diseases and Therapy2193-82292193-63822025-07-011481935195210.1007/s40121-025-01198-zClinical Characteristics and Prognosis of AIDS Complicated with Talaromycosis marneffei Infection: a Single-Center Retrospective StudyZhangyan Weng0Yijie Lin1Wenliang Dai2Yijuan Zheng3Huatang Zhang4Minghui Zheng5Haoyi He6Youzhi Hong7Dawu Zeng8Zhijun Su9Xueping Yu10Department of Infection Disease, Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian Province, Fujian Medical University Affiliated First Quanzhou HospitalDepartment of Infection Disease, Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian Province, Fujian Medical University Affiliated First Quanzhou HospitalDepartment of Respiratory and Critical Care Medicine, Nan’an First HospitalDepartment of Infection Disease, Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian Province, Fujian Medical University Affiliated First Quanzhou HospitalDepartment of Infection Disease, Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian Province, Fujian Medical University Affiliated First Quanzhou HospitalDepartment of Infection Disease, Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian Province, Fujian Medical University Affiliated First Quanzhou HospitalDepartment of Infection Disease, Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian Province, Fujian Medical University Affiliated First Quanzhou HospitalDepartment of Respiratory and Critical Care Medicine, Nan’an First HospitalDepartment of Liver Center, The First Hospital Affiliated to Fujian Medical UniversityDepartment of Infection Disease, Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian Province, Fujian Medical University Affiliated First Quanzhou HospitalDepartment of Infection Disease, Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian Province, Fujian Medical University Affiliated First Quanzhou HospitalAbstract Introduction The objective of the study was to determine the clinical features and prognostic risk factors of acquired immunodeficiency syndrome (AIDS) combined with Talaromyces marneffei (TM) infection. Methods We retrospectively analyzed the clinical data of 133 hospitalized patients diagnosed with AIDS and TM co-infection. Patients were divided into an improvement group and a deterioration group on the basis of their discharge outcomes. To further investigate the severity of adverse outcomes, subgroup analysis was performed on the deterioration group. Due to the issue of complete separation in the data, Firth’s logistic regression model was employed to identify independent prognostic factors. Finally, the predictive performance of the model was evaluated using the receiver operating characteristic (ROC) curve. Results Among 133 patients with AIDS and TM co-infection, the main manifestations were fever (93.23%) and severe immunodeficiency with median CD4+ T cell count of 8.50 cells/μL, with blood culture showing the highest positive rate (93.85%). Firth’s logistic regression analysis revealed that timely antifungal therapy (OR 0.004, 95% CI <0.001–0.047, P < 0.001) and higher baseline albumin (ALB) levels (OR 0.858, 95% CI 0.732–0.973, P = 0.016) were independent protective factors for improving patient prognosis. The area under the receiver operating characteristic (ROC) curve (AUC) of the model was 0.930 (95% CI 0.878–0.982). Conclusions Timely antifungal therapy and good nutritional status are key determinants of prognosis in patients with AIDS and TM co-infection. Early diagnosis, prompt initiation of effective treatment, and active nutritional support are of great significance for improving patient survival outcomes.https://doi.org/10.1007/s40121-025-01198-zClinical characteristicsPrognostic risk factorsPredictive modelTalaromyces marneffeiAIDS |
| spellingShingle | Zhangyan Weng Yijie Lin Wenliang Dai Yijuan Zheng Huatang Zhang Minghui Zheng Haoyi He Youzhi Hong Dawu Zeng Zhijun Su Xueping Yu Clinical Characteristics and Prognosis of AIDS Complicated with Talaromycosis marneffei Infection: a Single-Center Retrospective Study Infectious Diseases and Therapy Clinical characteristics Prognostic risk factors Predictive model Talaromyces marneffei AIDS |
| title | Clinical Characteristics and Prognosis of AIDS Complicated with Talaromycosis marneffei Infection: a Single-Center Retrospective Study |
| title_full | Clinical Characteristics and Prognosis of AIDS Complicated with Talaromycosis marneffei Infection: a Single-Center Retrospective Study |
| title_fullStr | Clinical Characteristics and Prognosis of AIDS Complicated with Talaromycosis marneffei Infection: a Single-Center Retrospective Study |
| title_full_unstemmed | Clinical Characteristics and Prognosis of AIDS Complicated with Talaromycosis marneffei Infection: a Single-Center Retrospective Study |
| title_short | Clinical Characteristics and Prognosis of AIDS Complicated with Talaromycosis marneffei Infection: a Single-Center Retrospective Study |
| title_sort | clinical characteristics and prognosis of aids complicated with talaromycosis marneffei infection a single center retrospective study |
| topic | Clinical characteristics Prognostic risk factors Predictive model Talaromyces marneffei AIDS |
| url | https://doi.org/10.1007/s40121-025-01198-z |
| work_keys_str_mv | AT zhangyanweng clinicalcharacteristicsandprognosisofaidscomplicatedwithtalaromycosismarneffeiinfectionasinglecenterretrospectivestudy AT yijielin clinicalcharacteristicsandprognosisofaidscomplicatedwithtalaromycosismarneffeiinfectionasinglecenterretrospectivestudy AT wenliangdai clinicalcharacteristicsandprognosisofaidscomplicatedwithtalaromycosismarneffeiinfectionasinglecenterretrospectivestudy AT yijuanzheng clinicalcharacteristicsandprognosisofaidscomplicatedwithtalaromycosismarneffeiinfectionasinglecenterretrospectivestudy AT huatangzhang clinicalcharacteristicsandprognosisofaidscomplicatedwithtalaromycosismarneffeiinfectionasinglecenterretrospectivestudy AT minghuizheng clinicalcharacteristicsandprognosisofaidscomplicatedwithtalaromycosismarneffeiinfectionasinglecenterretrospectivestudy AT haoyihe clinicalcharacteristicsandprognosisofaidscomplicatedwithtalaromycosismarneffeiinfectionasinglecenterretrospectivestudy AT youzhihong clinicalcharacteristicsandprognosisofaidscomplicatedwithtalaromycosismarneffeiinfectionasinglecenterretrospectivestudy AT dawuzeng clinicalcharacteristicsandprognosisofaidscomplicatedwithtalaromycosismarneffeiinfectionasinglecenterretrospectivestudy AT zhijunsu clinicalcharacteristicsandprognosisofaidscomplicatedwithtalaromycosismarneffeiinfectionasinglecenterretrospectivestudy AT xuepingyu clinicalcharacteristicsandprognosisofaidscomplicatedwithtalaromycosismarneffeiinfectionasinglecenterretrospectivestudy |