External Validation of Risk Prediction Score for Candidemia in Critically Ill Patients: A Retrospective Observational Study
Candidemia is associated with high mortality in critically ill patients. Early diagnosis of candidemia is imperative for starting treatment. Therefore, this study was designed to externally validate the candidemia risk prediction scores. This single-center, retrospective observational study included...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/11/3/204 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849342720178388992 |
|---|---|
| author | Nurul Mazni Abdullah Saw Kian Cheah Raha Abdul Rahman Nadia Md Nor Muhammad Maaya Qurratu Aini Musthafa |
| author_facet | Nurul Mazni Abdullah Saw Kian Cheah Raha Abdul Rahman Nadia Md Nor Muhammad Maaya Qurratu Aini Musthafa |
| author_sort | Nurul Mazni Abdullah |
| collection | DOAJ |
| description | Candidemia is associated with high mortality in critically ill patients. Early diagnosis of candidemia is imperative for starting treatment. Therefore, this study was designed to externally validate the candidemia risk prediction scores. This single-center, retrospective observational study included all critically ill patients admitted to the intensive care unit at a tertiary referral center from January 2018 to December 2023. The risks and patient outcomes were analyzed using bivariate and multivariate regression analysis. A total of 500 patients were analyzed with 2 dropouts due to incomplete data. Candidemia incidence was 8.86%, with parenteral nutrition and candida colonization identified as independent risk factors. Compared to an established risk prediction score, this study demonstrated a sensitivity of 75.0% [59.7–86.8], a specificity of 65.4% [60.8–69.8], a negative predictive value of 96.4% [94.2–97.8], and a positive predictive value of 17.3% [14.5–20.5]. The candidemia group had a significantly higher mean SOFA score, longer time in ICU, longer hospital length of stay, and higher rates of both ICU and in-hospital mortality. This study shows that the risk prediction score is more effective as a tool for excluding rather than predicting candidemia. We recommend against using it as the sole diagnostic guide. |
| format | Article |
| id | doaj-art-debbd890051640a8aeaf0bafb3f73d53 |
| institution | Kabale University |
| issn | 2309-608X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj-art-debbd890051640a8aeaf0bafb3f73d532025-08-20T03:43:16ZengMDPI AGJournal of Fungi2309-608X2025-03-0111320410.3390/jof11030204External Validation of Risk Prediction Score for Candidemia in Critically Ill Patients: A Retrospective Observational StudyNurul Mazni Abdullah0Saw Kian Cheah1Raha Abdul Rahman2Nadia Md Nor3Muhammad Maaya4Qurratu Aini Musthafa5Department of Anesthesiology and Intensive Care, Hospital Canselor Tuanku Muhriz, Jalan Yaacob Latiff, Andar Tun Razak, Cheras, Kuala Lumpur 56000, MalaysiaDepartment of Anesthesiology and Intensive Care, Hospital Canselor Tuanku Muhriz, Jalan Yaacob Latiff, Andar Tun Razak, Cheras, Kuala Lumpur 56000, MalaysiaDepartment of Anesthesiology and Intensive Care, Hospital Canselor Tuanku Muhriz, Jalan Yaacob Latiff, Andar Tun Razak, Cheras, Kuala Lumpur 56000, MalaysiaDepartment of Anesthesiology and Intensive Care, Hospital Canselor Tuanku Muhriz, Jalan Yaacob Latiff, Andar Tun Razak, Cheras, Kuala Lumpur 56000, MalaysiaDepartment of Anesthesiology and Intensive Care, Hospital Canselor Tuanku Muhriz, Jalan Yaacob Latiff, Andar Tun Razak, Cheras, Kuala Lumpur 56000, MalaysiaDepartment of Anesthesiology and Intensive Care, Hospital Canselor Tuanku Muhriz, Jalan Yaacob Latiff, Andar Tun Razak, Cheras, Kuala Lumpur 56000, MalaysiaCandidemia is associated with high mortality in critically ill patients. Early diagnosis of candidemia is imperative for starting treatment. Therefore, this study was designed to externally validate the candidemia risk prediction scores. This single-center, retrospective observational study included all critically ill patients admitted to the intensive care unit at a tertiary referral center from January 2018 to December 2023. The risks and patient outcomes were analyzed using bivariate and multivariate regression analysis. A total of 500 patients were analyzed with 2 dropouts due to incomplete data. Candidemia incidence was 8.86%, with parenteral nutrition and candida colonization identified as independent risk factors. Compared to an established risk prediction score, this study demonstrated a sensitivity of 75.0% [59.7–86.8], a specificity of 65.4% [60.8–69.8], a negative predictive value of 96.4% [94.2–97.8], and a positive predictive value of 17.3% [14.5–20.5]. The candidemia group had a significantly higher mean SOFA score, longer time in ICU, longer hospital length of stay, and higher rates of both ICU and in-hospital mortality. This study shows that the risk prediction score is more effective as a tool for excluding rather than predicting candidemia. We recommend against using it as the sole diagnostic guide.https://www.mdpi.com/2309-608X/11/3/204candidemiaclinical prediction ruleintensive carerisk factorsacute kidney injury |
| spellingShingle | Nurul Mazni Abdullah Saw Kian Cheah Raha Abdul Rahman Nadia Md Nor Muhammad Maaya Qurratu Aini Musthafa External Validation of Risk Prediction Score for Candidemia in Critically Ill Patients: A Retrospective Observational Study Journal of Fungi candidemia clinical prediction rule intensive care risk factors acute kidney injury |
| title | External Validation of Risk Prediction Score for Candidemia in Critically Ill Patients: A Retrospective Observational Study |
| title_full | External Validation of Risk Prediction Score for Candidemia in Critically Ill Patients: A Retrospective Observational Study |
| title_fullStr | External Validation of Risk Prediction Score for Candidemia in Critically Ill Patients: A Retrospective Observational Study |
| title_full_unstemmed | External Validation of Risk Prediction Score for Candidemia in Critically Ill Patients: A Retrospective Observational Study |
| title_short | External Validation of Risk Prediction Score for Candidemia in Critically Ill Patients: A Retrospective Observational Study |
| title_sort | external validation of risk prediction score for candidemia in critically ill patients a retrospective observational study |
| topic | candidemia clinical prediction rule intensive care risk factors acute kidney injury |
| url | https://www.mdpi.com/2309-608X/11/3/204 |
| work_keys_str_mv | AT nurulmazniabdullah externalvalidationofriskpredictionscoreforcandidemiaincriticallyillpatientsaretrospectiveobservationalstudy AT sawkiancheah externalvalidationofriskpredictionscoreforcandidemiaincriticallyillpatientsaretrospectiveobservationalstudy AT rahaabdulrahman externalvalidationofriskpredictionscoreforcandidemiaincriticallyillpatientsaretrospectiveobservationalstudy AT nadiamdnor externalvalidationofriskpredictionscoreforcandidemiaincriticallyillpatientsaretrospectiveobservationalstudy AT muhammadmaaya externalvalidationofriskpredictionscoreforcandidemiaincriticallyillpatientsaretrospectiveobservationalstudy AT qurratuainimusthafa externalvalidationofriskpredictionscoreforcandidemiaincriticallyillpatientsaretrospectiveobservationalstudy |