Vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans: A pilot study.
Vibration offers a potential alternative modality for transcutaneous auricular vagus nerve stimulation (taVNS). However, mechanisms of action are not well-defined. The goal of this pilot study was to evaluate the potential of vibrotactile stimulation of the outer ear as a method for activating centr...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0310917 |
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| author | Kara M Donovan Joshua D Adams Ki Yun Park Phillip Demarest Gansheng Tan Jon T Willie Peter Brunner Jenna L Gorlewicz Eric C Leuthardt |
| author_facet | Kara M Donovan Joshua D Adams Ki Yun Park Phillip Demarest Gansheng Tan Jon T Willie Peter Brunner Jenna L Gorlewicz Eric C Leuthardt |
| author_sort | Kara M Donovan |
| collection | DOAJ |
| description | Vibration offers a potential alternative modality for transcutaneous auricular vagus nerve stimulation (taVNS). However, mechanisms of action are not well-defined. The goal of this pilot study was to evaluate the potential of vibrotactile stimulation of the outer ear as a method for activating central brain regions similarly to established vagal nerve stimulation methods. Seven patients with intractable epilepsy undergoing stereotactic electroencephalography (sEEG) monitoring participated in the study. Vibrotactile taVNS was administered across five vibration frequencies (2, 6, 12, 20, and 40 Hz) following a randomized stimulation pattern with 30 trials per frequency. Spectral coherence during stimulation was analyzed across theta (4-8 Hz), alpha (8-13 Hz), beta (13-30 Hz), and broadband gamma (70-170 Hz) frequency bands. At the group level, vibrotactile taVNS significantly increased coherence in theta (effect sizes 6 Hz: r = 0.311; 20 Hz: r = 0.316; 40 Hz: r = 0.264) and alpha bands (effect sizes 20 Hz: r = 0.455; 40 Hz: r = 0.402). Anatomically, multiple limbic brain regions exhibited increased coherence during taVNS compared to baseline. The percentage of total electrode pairs demonstrating increased coherence was also quantified at the individual level. Twenty Hz vibration resulted in the highest percentage of responder pairs across low-frequency coherence measures, with a group-average of 33% of electrode pairs responding, though inter-subject variability was present. Overall, vibrotactile taVNS induced significant low-frequency coherence increases involving several limbic system structures. Further, parametric characterization revealed the presence of inter-subject variability in terms of identifying the vibration frequency with the greatest coherence response. These findings encourage continued research into vibrotactile stimulation as an alternative modality for noninvasive vagus nerve stimulation. |
| format | Article |
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| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-deba1f40371345b1853a26252abae4382025-08-20T02:47:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01205e031091710.1371/journal.pone.0310917Vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans: A pilot study.Kara M DonovanJoshua D AdamsKi Yun ParkPhillip DemarestGansheng TanJon T WilliePeter BrunnerJenna L GorlewiczEric C LeuthardtVibration offers a potential alternative modality for transcutaneous auricular vagus nerve stimulation (taVNS). However, mechanisms of action are not well-defined. The goal of this pilot study was to evaluate the potential of vibrotactile stimulation of the outer ear as a method for activating central brain regions similarly to established vagal nerve stimulation methods. Seven patients with intractable epilepsy undergoing stereotactic electroencephalography (sEEG) monitoring participated in the study. Vibrotactile taVNS was administered across five vibration frequencies (2, 6, 12, 20, and 40 Hz) following a randomized stimulation pattern with 30 trials per frequency. Spectral coherence during stimulation was analyzed across theta (4-8 Hz), alpha (8-13 Hz), beta (13-30 Hz), and broadband gamma (70-170 Hz) frequency bands. At the group level, vibrotactile taVNS significantly increased coherence in theta (effect sizes 6 Hz: r = 0.311; 20 Hz: r = 0.316; 40 Hz: r = 0.264) and alpha bands (effect sizes 20 Hz: r = 0.455; 40 Hz: r = 0.402). Anatomically, multiple limbic brain regions exhibited increased coherence during taVNS compared to baseline. The percentage of total electrode pairs demonstrating increased coherence was also quantified at the individual level. Twenty Hz vibration resulted in the highest percentage of responder pairs across low-frequency coherence measures, with a group-average of 33% of electrode pairs responding, though inter-subject variability was present. Overall, vibrotactile taVNS induced significant low-frequency coherence increases involving several limbic system structures. Further, parametric characterization revealed the presence of inter-subject variability in terms of identifying the vibration frequency with the greatest coherence response. These findings encourage continued research into vibrotactile stimulation as an alternative modality for noninvasive vagus nerve stimulation.https://doi.org/10.1371/journal.pone.0310917 |
| spellingShingle | Kara M Donovan Joshua D Adams Ki Yun Park Phillip Demarest Gansheng Tan Jon T Willie Peter Brunner Jenna L Gorlewicz Eric C Leuthardt Vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans: A pilot study. PLoS ONE |
| title | Vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans: A pilot study. |
| title_full | Vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans: A pilot study. |
| title_fullStr | Vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans: A pilot study. |
| title_full_unstemmed | Vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans: A pilot study. |
| title_short | Vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans: A pilot study. |
| title_sort | vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans a pilot study |
| url | https://doi.org/10.1371/journal.pone.0310917 |
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