Data fitting and optimal control strategies for HBV acute patient cases in the United States
Infection with Hepatitis B Virus (HBV) has been a serious public health issue worldwide. It caused more than one million fatalities per year. The mathematical modelling of the disease allows better understanding of the transmission of the disease and help the government policy makers to choose the b...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-06-01
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| Series: | Infectious Disease Modelling |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468042725000053 |
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| author | Xuebing Chen Yong Li Nurbek Azimaqin Yan Wu Changlei Tan Xuyue Duan Yiyi Yuan |
| author_facet | Xuebing Chen Yong Li Nurbek Azimaqin Yan Wu Changlei Tan Xuyue Duan Yiyi Yuan |
| author_sort | Xuebing Chen |
| collection | DOAJ |
| description | Infection with Hepatitis B Virus (HBV) has been a serious public health issue worldwide. It caused more than one million fatalities per year. The mathematical modelling of the disease allows better understanding of the transmission of the disease and help the government policy makers to choose the best control strategies. With this inspiration, we proposed a novel dynamic model by incorporating infection-age structure to imitate the transmission of HBV, especially the age heterogeneity in horizontal and vertical (mother-to-child) transmission modes. We also discussed its impact on control measures and analyzed the dynamics of waning immunity and reinfection. We conducted sensitivity analysis to evaluate the effectiveness of each control measure. Our research concentrates on HBV acute patient cases in the United States data from Centre for Disease Control and Prevention (CDC). Our findings show that a mixed approach by including vaccination, medication and periodic health assessments can effectively control HBV transmission. Among these measures, we found that early vaccination with a single-dose vaccine of US$50 is the most cost-effective control strategy. |
| format | Article |
| id | doaj-art-deb3463478d744ef8f2f61a162fdbba2 |
| institution | DOAJ |
| issn | 2468-0427 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Infectious Disease Modelling |
| spelling | doaj-art-deb3463478d744ef8f2f61a162fdbba22025-08-20T02:41:37ZengKeAi Communications Co., Ltd.Infectious Disease Modelling2468-04272025-06-0110266067910.1016/j.idm.2025.02.004Data fitting and optimal control strategies for HBV acute patient cases in the United StatesXuebing Chen0Yong Li1Nurbek Azimaqin2Yan Wu3Changlei Tan4Xuyue Duan5Yiyi Yuan6School of Information and Mathematics, Yangtze University, Jingzhou, Hubei, 434023, ChinaSchool of Information and Mathematics, Yangtze University, Jingzhou, Hubei, 434023, China; Corresponding author.College of Mathematics and Physics, Xinjiang Agricultural University, Urumqi, 830052, ChinaInstitute of Operations Research and Information Engineering, Beijing University of Technology, Beijing, 100124, China; Corresponding author.Information Engineering College, Hunan Applied Technology University, Changde, 415100, ChinaYangtze River Engineering Vocational College, Jingzhou, Hubei, 434023, ChinaViterbi School of Engineering, University of Southern California, Los Angeles, CA, 90 0 07, USAInfection with Hepatitis B Virus (HBV) has been a serious public health issue worldwide. It caused more than one million fatalities per year. The mathematical modelling of the disease allows better understanding of the transmission of the disease and help the government policy makers to choose the best control strategies. With this inspiration, we proposed a novel dynamic model by incorporating infection-age structure to imitate the transmission of HBV, especially the age heterogeneity in horizontal and vertical (mother-to-child) transmission modes. We also discussed its impact on control measures and analyzed the dynamics of waning immunity and reinfection. We conducted sensitivity analysis to evaluate the effectiveness of each control measure. Our research concentrates on HBV acute patient cases in the United States data from Centre for Disease Control and Prevention (CDC). Our findings show that a mixed approach by including vaccination, medication and periodic health assessments can effectively control HBV transmission. Among these measures, we found that early vaccination with a single-dose vaccine of US$50 is the most cost-effective control strategy.http://www.sciencedirect.com/science/article/pii/S2468042725000053HBVInfection-ageOptimal controlCost-effectivenessData fitting |
| spellingShingle | Xuebing Chen Yong Li Nurbek Azimaqin Yan Wu Changlei Tan Xuyue Duan Yiyi Yuan Data fitting and optimal control strategies for HBV acute patient cases in the United States Infectious Disease Modelling HBV Infection-age Optimal control Cost-effectiveness Data fitting |
| title | Data fitting and optimal control strategies for HBV acute patient cases in the United States |
| title_full | Data fitting and optimal control strategies for HBV acute patient cases in the United States |
| title_fullStr | Data fitting and optimal control strategies for HBV acute patient cases in the United States |
| title_full_unstemmed | Data fitting and optimal control strategies for HBV acute patient cases in the United States |
| title_short | Data fitting and optimal control strategies for HBV acute patient cases in the United States |
| title_sort | data fitting and optimal control strategies for hbv acute patient cases in the united states |
| topic | HBV Infection-age Optimal control Cost-effectiveness Data fitting |
| url | http://www.sciencedirect.com/science/article/pii/S2468042725000053 |
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