Inhibition of retinal neovascularization by Dendrobium polysaccharides: a review
Retinal neovascularization (RNV) is a critical pathological feature of vision-threatening ocular diseases, such as diabetic retinopathy, retinopathy of prematurity, and wet age-related macular degeneration, presenting a persistent therapeutic conundrum. Current clinical treatments primarily rely on...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1584553/full |
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| author | Dan Liu Dan Liu Dan Liu Dan Liu Xingwang Chen Xingwang Chen Xingwang Chen Xingwang Chen Shanjun Cai Shanjun Cai Shanjun Cai Shanjun Cai |
| author_facet | Dan Liu Dan Liu Dan Liu Dan Liu Xingwang Chen Xingwang Chen Xingwang Chen Xingwang Chen Shanjun Cai Shanjun Cai Shanjun Cai Shanjun Cai |
| author_sort | Dan Liu |
| collection | DOAJ |
| description | Retinal neovascularization (RNV) is a critical pathological feature of vision-threatening ocular diseases, such as diabetic retinopathy, retinopathy of prematurity, and wet age-related macular degeneration, presenting a persistent therapeutic conundrum. Current clinical treatments primarily rely on anti-vascular endothelial growth factor (VEGF) drugs and laser therapies, which face limitations including drug resistance, high costs, and potential damage to normal tissues. This underscores the need to develop novel therapeutic targets and cost-effective pharmacological interventions with improved safety profiles. Recent investigations highlight Dendrobium polysaccharides (DP), the primary bioactive components of the traditional medicinal herb Dendrobium, as promising multi-target therapeutic candidates. Studies have shown that Dendrobium polysaccharides significantly inhibits pathological angiogenesis by regulating the VEGF signaling pathway, inhibiting inflammatory response and oxidative stress, protecting the extracellular matrix, and reversing intestinal microecological disorders. This review systematically summarizes the structural and functional properties of DP, explores their mechanism of action and experimental evidence in retinal neovascularization, and analyzes their potential as a new therapeutic strategy for retinal diseases. This review also highlights the main limitations of current research: the uncertain relationship between the structure and activity of DP, the differences between pre-clinical models and human diseases, and the potential for structural optimization and the development of delivery systems. |
| format | Article |
| id | doaj-art-deb3255aa39e4ebd802c9b946622aa3f |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-deb3255aa39e4ebd802c9b946622aa3f2025-08-20T02:38:18ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-06-011610.3389/fphar.2025.15845531584553Inhibition of retinal neovascularization by Dendrobium polysaccharides: a reviewDan Liu0Dan Liu1Dan Liu2Dan Liu3Xingwang Chen4Xingwang Chen5Xingwang Chen6Xingwang Chen7Shanjun Cai8Shanjun Cai9Shanjun Cai10Shanjun Cai11Ophthalmology Department, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaGuizhou Eye Hospital, Zunyi, Guizhou, ChinaGuizhou Branch Center of National Clinical Research Center for Ophthalmology, Zunyi, Guizhou, ChinaKey Laboratory of Eye Diseases, High Education Institution in Guizhou Province, Zunyi, Guizhou, ChinaOphthalmology Department, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaGuizhou Eye Hospital, Zunyi, Guizhou, ChinaGuizhou Branch Center of National Clinical Research Center for Ophthalmology, Zunyi, Guizhou, ChinaKey Laboratory of Eye Diseases, High Education Institution in Guizhou Province, Zunyi, Guizhou, ChinaOphthalmology Department, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaGuizhou Eye Hospital, Zunyi, Guizhou, ChinaGuizhou Branch Center of National Clinical Research Center for Ophthalmology, Zunyi, Guizhou, ChinaKey Laboratory of Eye Diseases, High Education Institution in Guizhou Province, Zunyi, Guizhou, ChinaRetinal neovascularization (RNV) is a critical pathological feature of vision-threatening ocular diseases, such as diabetic retinopathy, retinopathy of prematurity, and wet age-related macular degeneration, presenting a persistent therapeutic conundrum. Current clinical treatments primarily rely on anti-vascular endothelial growth factor (VEGF) drugs and laser therapies, which face limitations including drug resistance, high costs, and potential damage to normal tissues. This underscores the need to develop novel therapeutic targets and cost-effective pharmacological interventions with improved safety profiles. Recent investigations highlight Dendrobium polysaccharides (DP), the primary bioactive components of the traditional medicinal herb Dendrobium, as promising multi-target therapeutic candidates. Studies have shown that Dendrobium polysaccharides significantly inhibits pathological angiogenesis by regulating the VEGF signaling pathway, inhibiting inflammatory response and oxidative stress, protecting the extracellular matrix, and reversing intestinal microecological disorders. This review systematically summarizes the structural and functional properties of DP, explores their mechanism of action and experimental evidence in retinal neovascularization, and analyzes their potential as a new therapeutic strategy for retinal diseases. This review also highlights the main limitations of current research: the uncertain relationship between the structure and activity of DP, the differences between pre-clinical models and human diseases, and the potential for structural optimization and the development of delivery systems.https://www.frontiersin.org/articles/10.3389/fphar.2025.1584553/fulldendrobium polysaccharidesretinal neovascularizationvascular endothelial growth factorantioxidantanti-inflammatory |
| spellingShingle | Dan Liu Dan Liu Dan Liu Dan Liu Xingwang Chen Xingwang Chen Xingwang Chen Xingwang Chen Shanjun Cai Shanjun Cai Shanjun Cai Shanjun Cai Inhibition of retinal neovascularization by Dendrobium polysaccharides: a review Frontiers in Pharmacology dendrobium polysaccharides retinal neovascularization vascular endothelial growth factor antioxidant anti-inflammatory |
| title | Inhibition of retinal neovascularization by Dendrobium polysaccharides: a review |
| title_full | Inhibition of retinal neovascularization by Dendrobium polysaccharides: a review |
| title_fullStr | Inhibition of retinal neovascularization by Dendrobium polysaccharides: a review |
| title_full_unstemmed | Inhibition of retinal neovascularization by Dendrobium polysaccharides: a review |
| title_short | Inhibition of retinal neovascularization by Dendrobium polysaccharides: a review |
| title_sort | inhibition of retinal neovascularization by dendrobium polysaccharides a review |
| topic | dendrobium polysaccharides retinal neovascularization vascular endothelial growth factor antioxidant anti-inflammatory |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1584553/full |
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