Correlation between estimated GFR using serum creatinine and cystatin C-based CKD-EPI equations and measured GFR via Tc-99m DTPA scintigraphy in Pakistani population with chronic kidney disease
Abstract Background The study aimed to find the correlation between estimated GFR (eGFR) using serum creatinine and cystatin C-based CKD-EPI equations, and the measured GFR (mGFR) obtained via Tc-99 m DTPA scintigraphy in Pakistani population with chronic kidney disease (CKD). Methods This was an ob...
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2025-06-01
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| Series: | The Egyptian Journal of Internal Medicine |
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| Online Access: | https://doi.org/10.1186/s43162-025-00482-1 |
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| author | Warda Ahmad Tania Jabbar Nayyar Rubab Farkhanda Gillani Muhammad Shahzad Afzal Shahar Bano Muhammad Babar Imran |
| author_facet | Warda Ahmad Tania Jabbar Nayyar Rubab Farkhanda Gillani Muhammad Shahzad Afzal Shahar Bano Muhammad Babar Imran |
| author_sort | Warda Ahmad |
| collection | DOAJ |
| description | Abstract Background The study aimed to find the correlation between estimated GFR (eGFR) using serum creatinine and cystatin C-based CKD-EPI equations, and the measured GFR (mGFR) obtained via Tc-99 m DTPA scintigraphy in Pakistani population with chronic kidney disease (CKD). Methods This was an observational cross-sectional study conducted in Nuclear Medicine department of PINUM Cancer Hospital, Faisalabad, Pakistan, from July 2024 to January 2025. Patients with CKD were enrolled and the GFR was measured using Tc-99 m DTPA dynamic scintigraphy. Serum cystatin C and serum creatinine levels were analyzed to estimate GFR using CKD-EPI equations. Pearson’s correlation test and Bland Altman analysis were employed to evaluate the relationship between eGFR and mGFR. Results A total of 97 patients (53 males and 44 females), with a mean age of 43.99 ± 12.04 years (Range: 18 to 66 years), were included in this study. Patients were subcategorized into two groups based on mGFR values. A strong positive correlation was observed between mGFR and eGFR in the overall population (r > 0.8, p < 0.001) and in Group 2 with GFR < 60 ml/min/1.73m2 (r > 0.7, p < 0.001). In Group 1 with GFR ≥ 60 ml/min/1.73m2, a moderate positive correlation was noted (r > 0.3, p < 0.05). Bland–Altman analysis further demonstrated that eGFRcys showed the best agreement with mGFR among the tested equations. Conclusion In the assessment of renal function using CKD-EPI equations, cystatin C-based formulas demonstrated superior correlation compared to creatinine-based equations in the Pakistani population with CKD. |
| format | Article |
| id | doaj-art-deb0b0511bae41728da2ab0e931f4f97 |
| institution | Kabale University |
| issn | 2090-9098 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Internal Medicine |
| spelling | doaj-art-deb0b0511bae41728da2ab0e931f4f972025-08-20T03:27:18ZengSpringerOpenThe Egyptian Journal of Internal Medicine2090-90982025-06-0137111010.1186/s43162-025-00482-1Correlation between estimated GFR using serum creatinine and cystatin C-based CKD-EPI equations and measured GFR via Tc-99m DTPA scintigraphy in Pakistani population with chronic kidney diseaseWarda Ahmad0Tania Jabbar1Nayyar Rubab2Farkhanda Gillani3Muhammad Shahzad Afzal4Shahar Bano5Muhammad Babar Imran6Punjab Institute of Nuclear MedicinePunjab Institute of Nuclear MedicinePunjab Institute of Nuclear MedicinePunjab Institute of Nuclear MedicinePunjab Institute of Nuclear MedicinePunjab Institute of Nuclear MedicinePunjab Institute of Nuclear MedicineAbstract Background The study aimed to find the correlation between estimated GFR (eGFR) using serum creatinine and cystatin C-based CKD-EPI equations, and the measured GFR (mGFR) obtained via Tc-99 m DTPA scintigraphy in Pakistani population with chronic kidney disease (CKD). Methods This was an observational cross-sectional study conducted in Nuclear Medicine department of PINUM Cancer Hospital, Faisalabad, Pakistan, from July 2024 to January 2025. Patients with CKD were enrolled and the GFR was measured using Tc-99 m DTPA dynamic scintigraphy. Serum cystatin C and serum creatinine levels were analyzed to estimate GFR using CKD-EPI equations. Pearson’s correlation test and Bland Altman analysis were employed to evaluate the relationship between eGFR and mGFR. Results A total of 97 patients (53 males and 44 females), with a mean age of 43.99 ± 12.04 years (Range: 18 to 66 years), were included in this study. Patients were subcategorized into two groups based on mGFR values. A strong positive correlation was observed between mGFR and eGFR in the overall population (r > 0.8, p < 0.001) and in Group 2 with GFR < 60 ml/min/1.73m2 (r > 0.7, p < 0.001). In Group 1 with GFR ≥ 60 ml/min/1.73m2, a moderate positive correlation was noted (r > 0.3, p < 0.05). Bland–Altman analysis further demonstrated that eGFRcys showed the best agreement with mGFR among the tested equations. Conclusion In the assessment of renal function using CKD-EPI equations, cystatin C-based formulas demonstrated superior correlation compared to creatinine-based equations in the Pakistani population with CKD.https://doi.org/10.1186/s43162-025-00482-1Chronic kidney diseaseCKD-EPI equationsCystatin CDTPA scan |
| spellingShingle | Warda Ahmad Tania Jabbar Nayyar Rubab Farkhanda Gillani Muhammad Shahzad Afzal Shahar Bano Muhammad Babar Imran Correlation between estimated GFR using serum creatinine and cystatin C-based CKD-EPI equations and measured GFR via Tc-99m DTPA scintigraphy in Pakistani population with chronic kidney disease The Egyptian Journal of Internal Medicine Chronic kidney disease CKD-EPI equations Cystatin C DTPA scan |
| title | Correlation between estimated GFR using serum creatinine and cystatin C-based CKD-EPI equations and measured GFR via Tc-99m DTPA scintigraphy in Pakistani population with chronic kidney disease |
| title_full | Correlation between estimated GFR using serum creatinine and cystatin C-based CKD-EPI equations and measured GFR via Tc-99m DTPA scintigraphy in Pakistani population with chronic kidney disease |
| title_fullStr | Correlation between estimated GFR using serum creatinine and cystatin C-based CKD-EPI equations and measured GFR via Tc-99m DTPA scintigraphy in Pakistani population with chronic kidney disease |
| title_full_unstemmed | Correlation between estimated GFR using serum creatinine and cystatin C-based CKD-EPI equations and measured GFR via Tc-99m DTPA scintigraphy in Pakistani population with chronic kidney disease |
| title_short | Correlation between estimated GFR using serum creatinine and cystatin C-based CKD-EPI equations and measured GFR via Tc-99m DTPA scintigraphy in Pakistani population with chronic kidney disease |
| title_sort | correlation between estimated gfr using serum creatinine and cystatin c based ckd epi equations and measured gfr via tc 99m dtpa scintigraphy in pakistani population with chronic kidney disease |
| topic | Chronic kidney disease CKD-EPI equations Cystatin C DTPA scan |
| url | https://doi.org/10.1186/s43162-025-00482-1 |
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