Successful Treatment with Bosentan of Lower Extremity Ulcers in a Scleroderma Patient
Digital ulcers are a well-known problem in patients with systemic sclerosis. Lower extremity ulcers are less prevalent but are also a challenging and underestimated complication of the disease causing important pain and morbidity. Bosentan, an oral dual endothelin receptor antagonist, has been shown...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/690591 |
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| author | Alix Naert Petra De Haes |
| author_facet | Alix Naert Petra De Haes |
| author_sort | Alix Naert |
| collection | DOAJ |
| description | Digital ulcers are a well-known problem in patients with systemic sclerosis. Lower extremity ulcers are less prevalent but are also a challenging and underestimated complication of the disease causing important pain and morbidity. Bosentan, an oral dual endothelin receptor antagonist, has been shown to be effective in preventing digital ulcers in patients with systemic sclerosis. A few recent observations showed the efficacy of bosentan for accelerating the healing of nondigital ulcers in scleroderma patients. This report deals with a 48-year-old patient with systemic sclerosis who developed painful ulcers on the left ankle and hallux. The ulcers were refractory to a combination of vasodilator therapy with a calcium antagonist and several courses of intravenous prostanoids, low molecular weight heparin, aspirin, simvastatin, and intensive local treatment. Bosentan treatment showed spectacular healing of the ulcers already after 4 months of therapy. This case supports the previous few observations of accelerating wound healing of lower extremity ulcers in systemic sclerosis patients with bosentan treatment. |
| format | Article |
| id | doaj-art-deaf504c7e6745a7826fcc3028f8dfb3 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-deaf504c7e6745a7826fcc3028f8dfb32025-08-20T03:26:16ZengWileyCase Reports in Medicine1687-96271687-96352013-01-01201310.1155/2013/690591690591Successful Treatment with Bosentan of Lower Extremity Ulcers in a Scleroderma PatientAlix Naert0Petra De Haes1Department of Dermatology, University Hospital, KU Leuven, Kapucijnenvoer 33, 3000 Leuven, BelgiumDepartment of Dermatology, University Hospital, KU Leuven, Kapucijnenvoer 33, 3000 Leuven, BelgiumDigital ulcers are a well-known problem in patients with systemic sclerosis. Lower extremity ulcers are less prevalent but are also a challenging and underestimated complication of the disease causing important pain and morbidity. Bosentan, an oral dual endothelin receptor antagonist, has been shown to be effective in preventing digital ulcers in patients with systemic sclerosis. A few recent observations showed the efficacy of bosentan for accelerating the healing of nondigital ulcers in scleroderma patients. This report deals with a 48-year-old patient with systemic sclerosis who developed painful ulcers on the left ankle and hallux. The ulcers were refractory to a combination of vasodilator therapy with a calcium antagonist and several courses of intravenous prostanoids, low molecular weight heparin, aspirin, simvastatin, and intensive local treatment. Bosentan treatment showed spectacular healing of the ulcers already after 4 months of therapy. This case supports the previous few observations of accelerating wound healing of lower extremity ulcers in systemic sclerosis patients with bosentan treatment.http://dx.doi.org/10.1155/2013/690591 |
| spellingShingle | Alix Naert Petra De Haes Successful Treatment with Bosentan of Lower Extremity Ulcers in a Scleroderma Patient Case Reports in Medicine |
| title | Successful Treatment with Bosentan of Lower Extremity Ulcers in a Scleroderma Patient |
| title_full | Successful Treatment with Bosentan of Lower Extremity Ulcers in a Scleroderma Patient |
| title_fullStr | Successful Treatment with Bosentan of Lower Extremity Ulcers in a Scleroderma Patient |
| title_full_unstemmed | Successful Treatment with Bosentan of Lower Extremity Ulcers in a Scleroderma Patient |
| title_short | Successful Treatment with Bosentan of Lower Extremity Ulcers in a Scleroderma Patient |
| title_sort | successful treatment with bosentan of lower extremity ulcers in a scleroderma patient |
| url | http://dx.doi.org/10.1155/2013/690591 |
| work_keys_str_mv | AT alixnaert successfultreatmentwithbosentanoflowerextremityulcersinasclerodermapatient AT petradehaes successfultreatmentwithbosentanoflowerextremityulcersinasclerodermapatient |