Concurrent Hairy Cell Leukemia and Metastatic Merkel Cell Carcinoma
Hairy cell leukemia (HCL) and Merkel cell carcinoma (MCC) are two rare malignancies with distinct cells of origin. HCL is a lymphoid malignancy of mature B cells, and MCC derives from neuroendocrine cell origin. HCL has a favorable prognosis with most patients achieving long-term remission and poten...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/1736854 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545955066413056 |
|---|---|
| author | Ajay Prakash Alhossain A. Khalafallah |
| author_facet | Ajay Prakash Alhossain A. Khalafallah |
| author_sort | Ajay Prakash |
| collection | DOAJ |
| description | Hairy cell leukemia (HCL) and Merkel cell carcinoma (MCC) are two rare malignancies with distinct cells of origin. HCL is a lymphoid malignancy of mature B cells, and MCC derives from neuroendocrine cell origin. HCL has a favorable prognosis with most patients achieving long-term remission and potential cure. In contrast, MCC is an aggressive malignancy affecting the skin and can metastasize quickly with a dismal prognosis. Immunocompromised patients, such as those with AIDS, posttransplant, and the elderly, have higher incidences than the general population, suggesting a possible immune mechanism. We report a case where a patient presented with HCL and metastatic MCC synchronously. This is the first reported case of these two rare malignancies occurring concurrently at initial presentation and may represent a role of immunosuppression in the pathogenesis of MCC. |
| format | Article |
| id | doaj-art-deae5482710f41c489d512cbe064641d |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-deae5482710f41c489d512cbe064641d2025-02-03T07:24:22ZengWileyCase Reports in Oncological Medicine2090-67062090-67142018-01-01201810.1155/2018/17368541736854Concurrent Hairy Cell Leukemia and Metastatic Merkel Cell CarcinomaAjay Prakash0Alhossain A. Khalafallah1Tasmanian Medical Laboratory, Launceston, Tasmania, AustraliaSpecialist Care Australia, Launceston, Tasmania, AustraliaHairy cell leukemia (HCL) and Merkel cell carcinoma (MCC) are two rare malignancies with distinct cells of origin. HCL is a lymphoid malignancy of mature B cells, and MCC derives from neuroendocrine cell origin. HCL has a favorable prognosis with most patients achieving long-term remission and potential cure. In contrast, MCC is an aggressive malignancy affecting the skin and can metastasize quickly with a dismal prognosis. Immunocompromised patients, such as those with AIDS, posttransplant, and the elderly, have higher incidences than the general population, suggesting a possible immune mechanism. We report a case where a patient presented with HCL and metastatic MCC synchronously. This is the first reported case of these two rare malignancies occurring concurrently at initial presentation and may represent a role of immunosuppression in the pathogenesis of MCC.http://dx.doi.org/10.1155/2018/1736854 |
| spellingShingle | Ajay Prakash Alhossain A. Khalafallah Concurrent Hairy Cell Leukemia and Metastatic Merkel Cell Carcinoma Case Reports in Oncological Medicine |
| title | Concurrent Hairy Cell Leukemia and Metastatic Merkel Cell Carcinoma |
| title_full | Concurrent Hairy Cell Leukemia and Metastatic Merkel Cell Carcinoma |
| title_fullStr | Concurrent Hairy Cell Leukemia and Metastatic Merkel Cell Carcinoma |
| title_full_unstemmed | Concurrent Hairy Cell Leukemia and Metastatic Merkel Cell Carcinoma |
| title_short | Concurrent Hairy Cell Leukemia and Metastatic Merkel Cell Carcinoma |
| title_sort | concurrent hairy cell leukemia and metastatic merkel cell carcinoma |
| url | http://dx.doi.org/10.1155/2018/1736854 |
| work_keys_str_mv | AT ajayprakash concurrenthairycellleukemiaandmetastaticmerkelcellcarcinoma AT alhossainakhalafallah concurrenthairycellleukemiaandmetastaticmerkelcellcarcinoma |