Progress in Continuous Flow Synthesis of Hydrogen-Bonded Organic Framework Material Synthons
Hydrogen-bonded organic framework (HOF) materials are typically formed by the self-assembly of small organic units (synthons) with specific functional groups through hydrogen bonding or other interactions. HOF is commonly used as an electrolyte for batteries. Well-designed HOF materials can enhance...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/1/41 |
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| author | Xingjun Yao Sanmiao Wen Ningning Ji Qiulin Deng Zhiliang Li Hongbing Wang Qianqian Shang |
| author_facet | Xingjun Yao Sanmiao Wen Ningning Ji Qiulin Deng Zhiliang Li Hongbing Wang Qianqian Shang |
| author_sort | Xingjun Yao |
| collection | DOAJ |
| description | Hydrogen-bonded organic framework (HOF) materials are typically formed by the self-assembly of small organic units (synthons) with specific functional groups through hydrogen bonding or other interactions. HOF is commonly used as an electrolyte for batteries. Well-designed HOF materials can enhance the proton exchange rate, thereby boosting battery performance. This paper reviews recent advancements in the continuous synthesis of HOF synthons, in the continuous synthesis of HOF’s unit small molecules enabling the multi-step, rapid, and in situ synthesis of synthons, such as carboxylic acid, diaminotriazine (DAT), urea, guanidine, imidazole, pyrazole, pyridine, thiazole, triazole, and tetrazole, with online monitoring. Continuous flow reactors facilitate fast chemical reactions and precise microfluidic control, offering superior reaction speed, product yield, and selectivity compared to batch processes. Integrating the continuous synthesis of synthons with the construction of HOF materials on a single platform is essential for achieving low-cost, safe, and efficient processing, especially for reactions involving toxic, flammable, or explosive substances. |
| format | Article |
| id | doaj-art-dea58d0ff1e740c0833b65eafb85c47e |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-dea58d0ff1e740c0833b65eafb85c47e2025-01-10T13:18:42ZengMDPI AGMolecules1420-30492024-12-013014110.3390/molecules30010041Progress in Continuous Flow Synthesis of Hydrogen-Bonded Organic Framework Material SynthonsXingjun Yao0Sanmiao Wen1Ningning Ji2Qiulin Deng3Zhiliang Li4Hongbing Wang5Qianqian Shang6Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, ChinaShandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, ChinaCollege of Chemistry and Chemical Engineering, Taishan University, Tai’an 271021, ChinaSchool of Materials Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, ChinaSchool of Materials Science and Engineering, Liaocheng University, Liaocheng 252059, ChinaSchool of Materials Science and Engineering, Liaocheng University, Liaocheng 252059, ChinaShandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, ChinaHydrogen-bonded organic framework (HOF) materials are typically formed by the self-assembly of small organic units (synthons) with specific functional groups through hydrogen bonding or other interactions. HOF is commonly used as an electrolyte for batteries. Well-designed HOF materials can enhance the proton exchange rate, thereby boosting battery performance. This paper reviews recent advancements in the continuous synthesis of HOF synthons, in the continuous synthesis of HOF’s unit small molecules enabling the multi-step, rapid, and in situ synthesis of synthons, such as carboxylic acid, diaminotriazine (DAT), urea, guanidine, imidazole, pyrazole, pyridine, thiazole, triazole, and tetrazole, with online monitoring. Continuous flow reactors facilitate fast chemical reactions and precise microfluidic control, offering superior reaction speed, product yield, and selectivity compared to batch processes. Integrating the continuous synthesis of synthons with the construction of HOF materials on a single platform is essential for achieving low-cost, safe, and efficient processing, especially for reactions involving toxic, flammable, or explosive substances.https://www.mdpi.com/1420-3049/30/1/41hydrogen-bonded organic frameworks (HOFs)synthonscontinuous flowmicroreactormicrochannel |
| spellingShingle | Xingjun Yao Sanmiao Wen Ningning Ji Qiulin Deng Zhiliang Li Hongbing Wang Qianqian Shang Progress in Continuous Flow Synthesis of Hydrogen-Bonded Organic Framework Material Synthons Molecules hydrogen-bonded organic frameworks (HOFs) synthons continuous flow microreactor microchannel |
| title | Progress in Continuous Flow Synthesis of Hydrogen-Bonded Organic Framework Material Synthons |
| title_full | Progress in Continuous Flow Synthesis of Hydrogen-Bonded Organic Framework Material Synthons |
| title_fullStr | Progress in Continuous Flow Synthesis of Hydrogen-Bonded Organic Framework Material Synthons |
| title_full_unstemmed | Progress in Continuous Flow Synthesis of Hydrogen-Bonded Organic Framework Material Synthons |
| title_short | Progress in Continuous Flow Synthesis of Hydrogen-Bonded Organic Framework Material Synthons |
| title_sort | progress in continuous flow synthesis of hydrogen bonded organic framework material synthons |
| topic | hydrogen-bonded organic frameworks (HOFs) synthons continuous flow microreactor microchannel |
| url | https://www.mdpi.com/1420-3049/30/1/41 |
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