Lipid Nanoparticle (LNP) ‐A Vector Suitable for Evolving Therapies for Advanced Hepatocellular Carcinoma (HCC)
Abstract Hepatocellular carcinoma (HCC) stands as the predominant form of primary liver cancer, characterized by a dismal prognosis. Therapeutic options for advanced HCC remain sparse, with efficacy significantly hampered by the emergence of drug resistance. In parallel with research into novel phar...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Global Challenges |
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| Online Access: | https://doi.org/10.1002/gch2.202400217 |
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| author | Mingxuan Zhang Ruiping Guo Zhuhui Yuan Hao Wang |
| author_facet | Mingxuan Zhang Ruiping Guo Zhuhui Yuan Hao Wang |
| author_sort | Mingxuan Zhang |
| collection | DOAJ |
| description | Abstract Hepatocellular carcinoma (HCC) stands as the predominant form of primary liver cancer, characterized by a dismal prognosis. Therapeutic options for advanced HCC remain sparse, with efficacy significantly hampered by the emergence of drug resistance. In parallel with research into novel pharmacological agents, advances in drug delivery systems represent a promising avenue for overcoming resistance. Lipid nanoparticles (LNPs) have demonstrated considerable efficacy in the delivery of nucleic acid‐based therapeutics and hold potential for broader applications in drug delivery. This review describes the development of LNPs tailored for HCC treatment and consolidates recent investigations using LNPs to target HCC. |
| format | Article |
| id | doaj-art-dea489b9aa90487eaa05a8f1c8c3a2f5 |
| institution | OA Journals |
| issn | 2056-6646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Global Challenges |
| spelling | doaj-art-dea489b9aa90487eaa05a8f1c8c3a2f52025-08-20T02:36:12ZengWileyGlobal Challenges2056-66462025-01-0191n/an/a10.1002/gch2.202400217Lipid Nanoparticle (LNP) ‐A Vector Suitable for Evolving Therapies for Advanced Hepatocellular Carcinoma (HCC)Mingxuan Zhang0Ruiping Guo1Zhuhui Yuan2Hao Wang3Department of Radiation Oncology Cancer Center of Peking University Third Hospital Peking University Third Hospital Haidian, 49 Huayuan North Road Beijing 100191 ChinaDepartment of Radiation Oncology Cancer Center of Peking University Third Hospital Peking University Third Hospital Haidian, 49 Huayuan North Road Beijing 100191 ChinaDepartment of Radiation Oncology Cancer Center of Peking University Third Hospital Peking University Third Hospital Haidian, 49 Huayuan North Road Beijing 100191 ChinaDepartment of Radiation Oncology Cancer Center of Peking University Third Hospital Peking University Third Hospital Haidian, 49 Huayuan North Road Beijing 100191 ChinaAbstract Hepatocellular carcinoma (HCC) stands as the predominant form of primary liver cancer, characterized by a dismal prognosis. Therapeutic options for advanced HCC remain sparse, with efficacy significantly hampered by the emergence of drug resistance. In parallel with research into novel pharmacological agents, advances in drug delivery systems represent a promising avenue for overcoming resistance. Lipid nanoparticles (LNPs) have demonstrated considerable efficacy in the delivery of nucleic acid‐based therapeutics and hold potential for broader applications in drug delivery. This review describes the development of LNPs tailored for HCC treatment and consolidates recent investigations using LNPs to target HCC.https://doi.org/10.1002/gch2.202400217chemotherapiesgene therapieshepatocellular carcinomaimmune therapylipid nanoparticles |
| spellingShingle | Mingxuan Zhang Ruiping Guo Zhuhui Yuan Hao Wang Lipid Nanoparticle (LNP) ‐A Vector Suitable for Evolving Therapies for Advanced Hepatocellular Carcinoma (HCC) Global Challenges chemotherapies gene therapies hepatocellular carcinoma immune therapy lipid nanoparticles |
| title | Lipid Nanoparticle (LNP) ‐A Vector Suitable for Evolving Therapies for Advanced Hepatocellular Carcinoma (HCC) |
| title_full | Lipid Nanoparticle (LNP) ‐A Vector Suitable for Evolving Therapies for Advanced Hepatocellular Carcinoma (HCC) |
| title_fullStr | Lipid Nanoparticle (LNP) ‐A Vector Suitable for Evolving Therapies for Advanced Hepatocellular Carcinoma (HCC) |
| title_full_unstemmed | Lipid Nanoparticle (LNP) ‐A Vector Suitable for Evolving Therapies for Advanced Hepatocellular Carcinoma (HCC) |
| title_short | Lipid Nanoparticle (LNP) ‐A Vector Suitable for Evolving Therapies for Advanced Hepatocellular Carcinoma (HCC) |
| title_sort | lipid nanoparticle lnp a vector suitable for evolving therapies for advanced hepatocellular carcinoma hcc |
| topic | chemotherapies gene therapies hepatocellular carcinoma immune therapy lipid nanoparticles |
| url | https://doi.org/10.1002/gch2.202400217 |
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