hnRNPA2B1 restrains granulosa cell ferroptosis by m6A/SLC7A11 in premature ovarian failure
Abstract Premature ovarian failure (POF) is a relatively severe gynecological disorder that is often accompanied by other systemic diseases. Here, this study identified that N6-methyladenosine (m6A) key enzyme heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1) was associated with POF pathophy...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13048-025-01718-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849332190871027712 |
|---|---|
| author | Jing Xiong Ling He Yongjing Zhang Xing Zhao |
| author_facet | Jing Xiong Ling He Yongjing Zhang Xing Zhao |
| author_sort | Jing Xiong |
| collection | DOAJ |
| description | Abstract Premature ovarian failure (POF) is a relatively severe gynecological disorder that is often accompanied by other systemic diseases. Here, this study identified that N6-methyladenosine (m6A) key enzyme heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1) was associated with POF pathophysiological process. In the chemotherapy induced POF animal and cells, hnRNPA2B1 was down-regulated upon cisplatin (CDDP) treatment. Functionally, hnRNPA2B1 inhibited the ferroptosis phenotype by m6A/SLC7A11 of granulosa cells. Moreover, hnRNPA2B1 up-regulated the autophagy by inhibiting PI3K/AKT/mTOR pathway of granulosa cells. Besides, rescue experiments confirmed that hnRNPA2B1/SLC7A11 axis repressed the ferroptosis of granulosa cells through m6A-dependent manner. In summary, the research identified the critical role of hnRNPA2B1 in granulosa cells ferroptosis, which provides novel insight for POF treatment. |
| format | Article |
| id | doaj-art-dea25832f6cf4cd68530edb387a535c2 |
| institution | Kabale University |
| issn | 1757-2215 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj-art-dea25832f6cf4cd68530edb387a535c22025-08-20T03:46:16ZengBMCJournal of Ovarian Research1757-22152025-07-0118111110.1186/s13048-025-01718-yhnRNPA2B1 restrains granulosa cell ferroptosis by m6A/SLC7A11 in premature ovarian failureJing Xiong0Ling He1Yongjing Zhang2Xing Zhao3Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South UniversityDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South UniversityDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South UniversityDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South UniversityAbstract Premature ovarian failure (POF) is a relatively severe gynecological disorder that is often accompanied by other systemic diseases. Here, this study identified that N6-methyladenosine (m6A) key enzyme heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1) was associated with POF pathophysiological process. In the chemotherapy induced POF animal and cells, hnRNPA2B1 was down-regulated upon cisplatin (CDDP) treatment. Functionally, hnRNPA2B1 inhibited the ferroptosis phenotype by m6A/SLC7A11 of granulosa cells. Moreover, hnRNPA2B1 up-regulated the autophagy by inhibiting PI3K/AKT/mTOR pathway of granulosa cells. Besides, rescue experiments confirmed that hnRNPA2B1/SLC7A11 axis repressed the ferroptosis of granulosa cells through m6A-dependent manner. In summary, the research identified the critical role of hnRNPA2B1 in granulosa cells ferroptosis, which provides novel insight for POF treatment.https://doi.org/10.1186/s13048-025-01718-yPremature ovarian failurehnRNPA2B1SLC7A11Ferroptosis. |
| spellingShingle | Jing Xiong Ling He Yongjing Zhang Xing Zhao hnRNPA2B1 restrains granulosa cell ferroptosis by m6A/SLC7A11 in premature ovarian failure Journal of Ovarian Research Premature ovarian failure hnRNPA2B1 SLC7A11 Ferroptosis. |
| title | hnRNPA2B1 restrains granulosa cell ferroptosis by m6A/SLC7A11 in premature ovarian failure |
| title_full | hnRNPA2B1 restrains granulosa cell ferroptosis by m6A/SLC7A11 in premature ovarian failure |
| title_fullStr | hnRNPA2B1 restrains granulosa cell ferroptosis by m6A/SLC7A11 in premature ovarian failure |
| title_full_unstemmed | hnRNPA2B1 restrains granulosa cell ferroptosis by m6A/SLC7A11 in premature ovarian failure |
| title_short | hnRNPA2B1 restrains granulosa cell ferroptosis by m6A/SLC7A11 in premature ovarian failure |
| title_sort | hnrnpa2b1 restrains granulosa cell ferroptosis by m6a slc7a11 in premature ovarian failure |
| topic | Premature ovarian failure hnRNPA2B1 SLC7A11 Ferroptosis. |
| url | https://doi.org/10.1186/s13048-025-01718-y |
| work_keys_str_mv | AT jingxiong hnrnpa2b1restrainsgranulosacellferroptosisbym6aslc7a11inprematureovarianfailure AT linghe hnrnpa2b1restrainsgranulosacellferroptosisbym6aslc7a11inprematureovarianfailure AT yongjingzhang hnrnpa2b1restrainsgranulosacellferroptosisbym6aslc7a11inprematureovarianfailure AT xingzhao hnrnpa2b1restrainsgranulosacellferroptosisbym6aslc7a11inprematureovarianfailure |