Relationship between aggregate index of systemic inflammation and mortality from CCD and malignant neoplasms in diabetic patients
Abstract Inflammation has been recognized as a pivotal factor in the pathophysiology of diabetes. The aggregate index of systemic inflammation (AISI) has recently been proposed as a novel biomarker for evaluating inflammatory status and predicting clinical outcomes. However, evidence on the associat...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-12094-4 |
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| author | Zhihui li Hua Li Peng Wang Wei Xie Guo Shao Hongwei Zhu |
| author_facet | Zhihui li Hua Li Peng Wang Wei Xie Guo Shao Hongwei Zhu |
| author_sort | Zhihui li |
| collection | DOAJ |
| description | Abstract Inflammation has been recognized as a pivotal factor in the pathophysiology of diabetes. The aggregate index of systemic inflammation (AISI) has recently been proposed as a novel biomarker for evaluating inflammatory status and predicting clinical outcomes. However, evidence on the association between AISI and mortality in diabetic patients remains limited. To address this knowledge gap, we aimed to investigate the association between AISI and mortality risk from cardio-cerebrovascular disease (CCD) and malignant neoplasms in diabetic patients. We analyzed data from the National Health and Nutrition Examination Survey (NHANES, 2001–2018). Multivariable-adjusted Cox models revealed strong associations between elevated AISI levels and CCD mortality (HR 1.18, 95% CI 1.11–1.26) as well as malignant neoplasm mortality (HR 1.20, 95% CI 1.10–1.30). Kaplan–Meier analysis showed that higher AISI was associated with lower survival in diabetic patients for both CCD and malignant neoplasms. Restricted cubic spline (RCS) analysis demonstrated an increased risk of mortality from CCD and malignant neoplasms in diabetic patients with elevated AISI levels. Subgroup and sensitivity analyses confirmed the robustness of these findings. In adults with diabetes, elevated AISI levels are strongly associated with an increased risk of mortality from CCD and malignant neoplasms. |
| format | Article |
| id | doaj-art-dea0f3a52ee145bf882385d4f225b8e3 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-dea0f3a52ee145bf882385d4f225b8e32025-08-20T03:05:18ZengNature PortfolioScientific Reports2045-23222025-07-0115111110.1038/s41598-025-12094-4Relationship between aggregate index of systemic inflammation and mortality from CCD and malignant neoplasms in diabetic patientsZhihui li0Hua Li1Peng Wang2Wei Xie3Guo Shao4Hongwei Zhu5The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and TechnologyThe Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and TechnologyThe Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and TechnologyInner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou Medical CollegeCenter for Translational Medicine, The Third People’s Hospital of Longgang DistrictThe Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and TechnologyAbstract Inflammation has been recognized as a pivotal factor in the pathophysiology of diabetes. The aggregate index of systemic inflammation (AISI) has recently been proposed as a novel biomarker for evaluating inflammatory status and predicting clinical outcomes. However, evidence on the association between AISI and mortality in diabetic patients remains limited. To address this knowledge gap, we aimed to investigate the association between AISI and mortality risk from cardio-cerebrovascular disease (CCD) and malignant neoplasms in diabetic patients. We analyzed data from the National Health and Nutrition Examination Survey (NHANES, 2001–2018). Multivariable-adjusted Cox models revealed strong associations between elevated AISI levels and CCD mortality (HR 1.18, 95% CI 1.11–1.26) as well as malignant neoplasm mortality (HR 1.20, 95% CI 1.10–1.30). Kaplan–Meier analysis showed that higher AISI was associated with lower survival in diabetic patients for both CCD and malignant neoplasms. Restricted cubic spline (RCS) analysis demonstrated an increased risk of mortality from CCD and malignant neoplasms in diabetic patients with elevated AISI levels. Subgroup and sensitivity analyses confirmed the robustness of these findings. In adults with diabetes, elevated AISI levels are strongly associated with an increased risk of mortality from CCD and malignant neoplasms.https://doi.org/10.1038/s41598-025-12094-4Cardio-cerebrovascular disease (CCD) mortalityMalignant neoplasm mortalityAggregate index of systemic inflammation (AISI)Diabetes |
| spellingShingle | Zhihui li Hua Li Peng Wang Wei Xie Guo Shao Hongwei Zhu Relationship between aggregate index of systemic inflammation and mortality from CCD and malignant neoplasms in diabetic patients Scientific Reports Cardio-cerebrovascular disease (CCD) mortality Malignant neoplasm mortality Aggregate index of systemic inflammation (AISI) Diabetes |
| title | Relationship between aggregate index of systemic inflammation and mortality from CCD and malignant neoplasms in diabetic patients |
| title_full | Relationship between aggregate index of systemic inflammation and mortality from CCD and malignant neoplasms in diabetic patients |
| title_fullStr | Relationship between aggregate index of systemic inflammation and mortality from CCD and malignant neoplasms in diabetic patients |
| title_full_unstemmed | Relationship between aggregate index of systemic inflammation and mortality from CCD and malignant neoplasms in diabetic patients |
| title_short | Relationship between aggregate index of systemic inflammation and mortality from CCD and malignant neoplasms in diabetic patients |
| title_sort | relationship between aggregate index of systemic inflammation and mortality from ccd and malignant neoplasms in diabetic patients |
| topic | Cardio-cerebrovascular disease (CCD) mortality Malignant neoplasm mortality Aggregate index of systemic inflammation (AISI) Diabetes |
| url | https://doi.org/10.1038/s41598-025-12094-4 |
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